DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and lta4h

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_998451.1	Gene:	lta4h / 406575	ZFINID:	ZDB-GENE-040426-2477	Length:	611	Species:	Danio rerio

Alignment Length:	718	Identity:	155/718 - (21%)
Similarity:	256/718 - (35%)	Gaps:	215/718 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LTQLENPDDF---------HFN-------------GTVKIQIEVLQNT-HNITLHSKDLTIDDTE 82
            :|.:.:|..|         |.|             |.|.:.:|||::. .::||.||||.|.
Zfish     1 MTPVSDPSSFSSLSKCSTKHLNLIYHVDFDRHVLKGKVALTVEVLEDKFSSLTLDSKDLKIS--- 62

  Fly    83 ITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYV 147
             .:|..|.....|       :...|.|          .|...|::|||...         |..:|
Zfish    63 -KVSANGQAAKFE-------LGAKHKF----------KGSPLEITLPFELS---------RGQHV 100

  Fly   148 --------NTVANETRWIS------------VTQFEPAAARLAFPCFDEPGYKASFAITLGYHKK 192
                    :..|...:|::            .:|.:....|...||.|.|..|.::...:...::
Zfish   101 IVEIEYETSPTATALQWLTPKQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPRE 165

  Fly   193 YTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNA 257
            ...|.:...:...|..|....|...|.:.:||.:||:|..:.....:..    |...|.|:....
Zfish   166 LVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIVVGALESREI----GPRSRVWSEKEY 226

  Fly   258 IDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAV-PDFSAGAMENWGLVTFAESTLLYSPEYS 321
            :|:..|.......:||..|.|.| .:...:.|.:.: |.|..|.||| ..:||...|:|
Zfish   227 VDEAAYEFAETETMLKTAESLAG-PYVWGQYDVLVLPPSFPYGGMEN-PCLTFVTPTVL------ 283

  Fly   322 SQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASL---CVEDIHPQ-------W 376
              ...:..|.::|||::|.|.|||||.:.|...|||||...|:..:   |:|....:       |
Zfish   284 --AGDRSLAGVIAHEISHSWTGNLVTNRTWEHFWLNEGHTVYIERMIARCMEGEQLRQFKGIGGW 346

  Fly   377 RTLQLESM-----SNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVI-RMMHLFL 435
            :.|. ||:     :|:||    :.:.:.|.:        ...|:|..:.|:||.::: .:..|..
Zfish   347 KELH-ESVKQFGANNVLT----NLVPNLHEV--------DTDEAFSSVPYEKGFALLYHLEELMG 398

  Fly   436 GEEAFRTGLKSYLEKYTYKNAEQDNLWES--LTQAAHKTGSLPK-DYNIKTIMDSWTLQTGYPVI 497
            |.|.|...:|||::.:.|.:...:. |::  .|....|...|.| |:|      :|....|...:
Zfish   399 GPEVFMGFVKSYIQLFAYGSVTTEE-WKNYLFTYFKDKVDILNKVDWN------AWMHTPGMAPV 456

  Fly   498 NVTRDYTSRTA--KLSQERYLLNTDVSRAHKGCWWVP------LSYTNQEEKDFNNTAPKEWMEC 554
            ....|.|...|  .|.|:                ||.      .|:|..:.|..|:....|:|..
Zfish   457 RPQYDTTMADACTSLCQK----------------WVKAKEADLASFTEADVKQLNSPQLIEFMAL 505

  Fly   555 TETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSE-DYHSIHVVNRAQLI 618
                     .:.:.|.|...|   .::...||:|    |.|      |:| .:..:.:..:||
Zfish   506 ---------LLQEDPLPLSHV---KKMGEVYKLN----NIK------NAEVRFRWLRICVKAQ-- 546

  Fly   619 DDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLIT 683
                   |  |:...:||::.:...|.:                              |||.|.|
Zfish   547 -------W--EEAVPLALKMATEQGRMK------------------------------FTRPLFT 572

  Fly   684 PIY 686
            .:|
Zfish   573 EVY 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	118/511 (23%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	21/114 (18%)
lta4h	NP_998451.1	leuko_A4_hydro	18..607	CDD:274120	152/701 (22%)
		M1_LTA4H	18..449	CDD:189006	115/494 (23%)
		Leuk-A4-hydro_C	467..606	CDD:286244	34/188 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910