Protein Alignment CG11951 and LTA4H

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_000886.1
• Gene: LTA4H / 4048
• HGNCID: 6710
• Length: 611
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 124/552 - (22%)
• Similarity: 219/552 - (39%)
• Gaps: 108/552 - (19%)

  Fly    54 GTVKIQIEVLQ-NTHNITLHSKDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKE 117
            ||..:.::..: |..::.|.:|||||:..     .|.|:|..               |.|.. ::
Human    37 GTAALTVQSQEDNLRSLVLDTKDLTIEKV-----VINGQEVK---------------YALGE-RQ 80

  Fly   118 LLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANET-------RWIS------------VTQFE 163
            ...|...|:|||.:.....::        |..::.||       :|::            .:|.:
Human    81 SYKGSPMEISLPIALSKNQEI--------VIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQ 137

  Fly   164 PAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYL 228
            ....|...||.|.|..|.::...:...|:...|.:...:...|....|......|.:.:|:..||
Human   138 AIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYL 202

  Fly   229 VAYSLNDFSHK---PSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQ 290
            :|..:.....:   |.||       .|:....:::..|.......:||..|:|.| .:...:.|.
Human   203 IALVVGALESRQIGPRTL-------VWSEKEQVEKSAYEFSETESMLKIAEDLGG-PYVWGQYDL 259

  Fly   291 IAV-PDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDL 354
            :.: |.|..|.||| ..:||...|||        ...:..:|::|||::|.|.|||||.|.|...
Human   260 LVLPPSFPYGGMEN-PCLTFVTPTLL--------AGDKSLSNVIAHEISHSWTGNLVTNKTWDHF 315

  Fly   355 WLNEGFATYV-ASLCVEDIHPQWRTLQL----ESMSNLLTIFRKDSLESSHPISRPIEMTSQISE 414
            |||||...|: ..:|......::|....    ..:.|.:..|.:     :||.::.:...:.|..
Human   316 WLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGE-----THPFTKLVVDLTDIDP 375

  Fly   415 --SFDEISYQKGSSVIRMMHLFL-GEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLP 476
              ::..:.|:||.:::..:...| |.|.|...||:|:||::||:...|: |:....:..|.   .
Human   376 DVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDD-WKDFLYSYFKD---K 436

  Fly   477 KDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEE- 540
            .|...:...::|....|.|.|....|.|           |.|..::.:.:   |:    |.:|:
Human   437 VDVLNQVDWNAWLYSPGLPPIKPNYDMT-----------LTNACIALSQR---WI----TAKEDD 483

  Fly   541 -KDFNNTAPKEWMECTETGESVPKTIHDLPGP 571
             ..||.|..|: :...:..|.:.:|:...|.|
Human   484 LNSFNATDLKD-LSSHQLNEFLAQTLQRAPLP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	106/467 (23%)
		ERAP1_C	574..902	CDD:463368
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	124/552 (22%)