Protein Alignment CG11951 and LNPEP

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 975
• Identity: 299/975 - (30%)
• Similarity: 481/975 - (49%)
• Gaps: 126/975 - (12%)

  Fly     3 CVFLILAA--------------------------LGL--SFAGEGSTYD--HFRLPTALRPQSYD 37
            |.|:|:.|                          :||  .||..|..:.  ..|||||:.|..|:
Human   186 CAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYE 250

  Fly    38 VRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEIT-LSQIGGEETTENCITST 101
            :.:...|.:   ..|.|:|.|.::.||.|.||.|||....|  :.:| :|.:..:|.....:...
Human   251 LSLHPNLTS---MTFRGSVTISVQALQVTWNIILHSTGHNI--SRVTFMSAVSSQEKQAEILEYA 310

  Fly   102 AVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAA 166
                .|....:...:.||||..|.|.:.:||.:.....|:|..||.:. :||.::.:.|||||.|
Human   311 ----YHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE-SNEKKYFAATQFEPLA 370

  Fly   167 ARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPD--YVWTSFEESLPMSTYLV 229
            ||.||||||||.:||:|.|.:...::||.|||||    :....:.|  .|...|.||:.||||||
Human   371 ARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMP----KKSSVVLDDGLVQDEFSESVKMSTYLV 431

  Fly   230 AYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVP 294
            |:.:.:..:....: ||||...:|.|..|.|..||.|...|:|::::..|.|::||.|:|.:|:|
Human   432 AFIVGEMKNLSQDV-NGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIP 495

  Fly   295 DFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEG 359
            ||.|||||||||:||.|.||||....||...::....|:||||||||||||||||||.|||||||
Human   496 DFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEG 560

  Fly   360 FATYVASLCVEDIHPQWRTLQLESMSNLL----TIFRKDSLESSHPISRPIEMTSQISESFDEIS 420
            |||::....:|.|..     :|.|..:.|    ...:||||.||||||..::.:.||.|.||.:|
Human   561 FATFMEYFSLEKIFK-----ELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLS 620

  Fly   421 YQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIM 485
            |.||||::.|:..:|.|:.|:..:..||..::|.:.:.|:||:|..:..::|      .::|.:|
Human   621 YFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT------LDVKRMM 679

  Fly   486 DSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN-------TDVSRAHKGCWWVPLSYTNQEEKDF 543
            .:||||.|:|::.|.:  ..:...:.|||:.||       :|.|.    .|.:||||.. |.:::
Human   680 KTWTLQKGFPLVTVQK--KGKELFIQQERFFLNMKPEIQPSDTSY----LWHIPLSYVT-EGRNY 737

  Fly   544 NNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHS 608
            :.......:: .::|      :.:|.....||..|..::..|.|:|...:|:.||..|....| .
Human   738 SKYQSVSLLD-KKSG------VINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPY-V 794

  Fly   609 IHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRF 673
            :...:||.||:::...|..|:...:.|..:|:||..|....|...|......:..:|.:..
Human   795 LSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLG---- 855

  Fly   674 FKNFTRRLITPIYEHL-NGI-NDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRS 736
            :.:...||:|.:::.| |.| ..|...|.......|::.:.::||:..:.:|.|.|:..:..|.:
Human   856 YMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMA 920

  Fly   737 EANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQR 801
            .   :....:|..:...|:....|  .|:.|.||..:|.......||..||::|..|::|..|..
Human   921 S---NGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYW 980

  Fly   802 YLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDS-ISKFYHPQSESMSELLPPLS 865
            .::.:.:| .:.|.|..:.:.:.:.....|.|||..::.:|.:. :.||             ||.
Human   981 LMKSSLNG-DNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKF-------------PLG 1031

  Fly   866 EQIFTQRDYDEFMNFMASSKDQLKDIE-------------QTISQSLETMLINVQWKERNYERFT 917
            .  :|.::......::.|:|..|.:::             :.:.::||.:.:|:||.|:|.:..|
Human  1032 S--YTVQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT 1094

  Fly   918  917
            Human  1095  1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	183/461 (40%)
		ERAP1_C	574..902	CDD:463368	74/343 (22%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	183/462 (40%)
		ERAP1_C	761..1081	CDD:463368	74/345 (21%)