DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and erap1b

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	961	Identity:	304/961 - (31%)
Similarity:	483/961 - (50%)	Gaps:	111/961 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLT 77
            :|.:||...::..|||..:.|..|::.|...|.:.|   |.|:|:|||||||:|..|.||||:|.
Zfish    33 ISSSGEPFPWNKMRLPDTISPLHYNLLIHPNLTSLD---FTGSVQIQIEVLQDTKTIILHSKNLQ 94

  Fly    78 IDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELL-AGQFYELSLPFSAKLQDQLAGY 141
            |....:..:.|..::..:     ....|......|.:.|.|| .|..|.:.|.|:|.|.:...|:
Zfish    95 ISSARLLDANIAQQQPLK-----VLEYPYFQQIALVSDKALLKRGHVYSVELHFAANLSESFHGF 154

  Fly   142 YRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRP 206
            |:|:| .|...:.|.::.||||..:||.||||||||.:||:|::.:....|:..|||||  :.|.
Zfish   155 YKSTY-RTSKGDVRVVASTQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMP--KLRT 216

  Fly   207 HESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKV 271
            .|.........|:.|:.||||||||.::||.....|..:|.....:|.|..|||.::|.:...|:
Zfish   217 LELKNGLFEDQFDVSVKMSTYLVAYIVSDFLSISKTSQHGVQISVYAVPEKIDQAEFALDAAVKL 281

  Fly   272 LKYYEELFGIKFPLPK--------------------VDQIAVPDFSAGAMENWGLVTFAESTLLY 316
            |.:|::.|.|.:||||                    ||..|:|||.:||||||||.|:.||.||:
Zfish   282 LDFYDDYFDIPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLF 346

  Fly   317 SPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQL 381
            .|..||...|.....|:|||||||||||||||:||.|||||||||.::..:.|...:|:   ||:
Zfish   347 DPHKSSASDKLGITMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPE---LQV 408

  Fly   382 ES--MSNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGL 444
            |.  :.........|||.||||:|.|:|..:||.|.||::||.||:.::.|:..||..:.|:.|:
Zfish   409 EDYFLGKCFEAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGI 473

  Fly   445 KSYLEKYTYKNAEQDNLWESLT--------------------QAAHKTGS----LPKDYNIKTIM 485
            ..||:.|:|:|....|||||||                    .:|..||:    ...:.::|.:|
Zfish   474 VKYLKHYSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMM 538

  Fly   486 DSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKE 550
            ::||||.|:|:|.:.  ...|..:|||||||.:.|:|:.....|.|||:|...:     :|....
Zfish   539 ETWTLQEGFPLITIA--VKGREVRLSQERYLKSDDLSQTSSFLWQVPLTYITSD-----STTVHR 596

  Fly   551 WMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRA 615
            ::..|:|      .:..||....|:.||..:|..|.|:|:...|..|| ||...::.::...:||
Zfish   597 FLLKTKT------DVLYLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLI-TLLKHNHTALSSNDRA 654

  Fly   616 QLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRF------- 673
            .||::.......|:...:.||.:..||.:|.|::|....|:.|         .|.::.
Zfish   655 SLINNAFQLVSVGKLPLDKALDLTLYLSKETEIMPVTQGFNEL---------VPLYKLMEKRDMV 710

  Fly   674 -FKNFTRRLITPIYEHLNGINDTVASEE-QQDKTILKAIVADWACSFEVSDCVTQALSFYRSWR- 735
             .:|..:..|..:::.|  |...:.::| ...:.:|::.:..:.|......||:.|...:..||
Zfish   711 ELENQMKGYILQLFQKL--IEQQLWTDEGSVSERMLRSYLLLFGCVRGHPPCVSNATQLFNLWRD 773

  Fly   736 SEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCS----QEV 796
            |:.|....|.|.:.:..|...|      ::.||||:.:|:::...:.|..|..:|..|    :..
Zfish   774 SDGNMSLPNDVTMAVFSVGART------EDGWDFLFEKYKESMYVSMKSRIKQALMTSPLDHKLK 832

  Fly   797 WVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELL 861
            |::::.||...     |:.||...|..:::.:...:..|..:|..|.||:.|.:...|.|::.::
Zfish   833 WMMEQSLEGEL-----IKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSIAHMV 892

  Fly   862 PPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKERN 912
            ..::.|..|:....|..||.:..:.:.....:.|.|::|.:..|::|.::|
Zfish   893 VGVTNQYSTREMLAEVRNFFSLLQPETGAELRCIQQAVENIEENIRWMDKN 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	191/501 (38%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	77/341 (23%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	170/420 (40%)
		M1_APN_2	54..548	CDD:189008	195/507 (38%)
		ERAP1_C	615..932	CDD:288671	75/339 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920