DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG6071

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	1004	Identity:	268/1004 - (26%)
Similarity:	461/1004 - (45%)	Gaps:	160/1004 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILAALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFH-FNGTVKIQIEVLQNTHNI 69
            |:.|.|..||               ::|..|::.|||:|.:.|:.: |.|.|.|.||..|.|..|
  Fly    12 LLSAKLAESF---------------VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVI 61

  Fly    70 TLHSKDLTIDDTEITL------SQIGGEETTENCITSTAVNPTHDFYILNTCKE--LLAGQFYEL 126
            .|:|.::||......:      .:||..: .:..|..|:        ::....|  |.:|:.|.|
  Fly    62 YLNSLNITISRQRTWIYRWASGRKIGALQ-IKRIIKKTS--------LIKIVIELPLRSGEIYTL 117

  Fly   127 SLPFSAKL-QDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYH 190
            ::.||..| :.|..||:...|..|   ...:.|.|:.||..|...|||||:|.::..:.|||.:.
  Fly   118 NMLFSGNLDRSQQYGYFAGYYDKT---PRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHD 179

  Fly   191 KKYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLND----FSHKPSTLPNGTLFRT 251
            :||..|||||..|.:|::.|.:||.|:|..|.|::|..|.::|:.    :|...:...|.|:
  Fly   180 RKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITV--- 241

  Fly   252 WARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLP-------KVDQIAVPDFSAGAMENWGLVTF 309
            |:||:..::.....|:.|.:...||.||.  :|||       |||.:.:|.::. .....|::.:
  Fly   242 WSRPHLAEKLAKVPEMTPNLFSKYETLFA--YPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVY 303

  Fly   310 AESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHP 374
            .|.  :.....:..|:.|||   :|..:|.||.|.||.::...:.::..|...|::...:.....
  Fly   304 GED--IVDSGQNGLESLQET---LAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKE 363

  Fly   375 QWRTLQLESMSNLLTIFRKDSLESSHPISRPIEMTSQISES-FDEISYQKGSSVIRMMHLFLGEE 438
            .:.|..|.  ...|.:...|||.....|:      :.:.|| ..::..:|...:|.|:.:.||::
  Fly   364 AYNTTHLS--KTRLDVLYHDSLAKVKSIA------TDVKESGHQKLRKKKMCLLIHMLKVALGDK 420

  Fly   439 AFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDY 503
            .|..||:.:.::|...:|....|||...:.|.::..||...::.|:|:||..|.|:|::.|.||.
  Fly   421 LFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDD 485

  Fly   504 TSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPK-EWMECTETGESVPKTIHD 567
            ..:...::|.|| ....:..:...|||||::|..:     |.|.|: ||:.|.:....:.:..|
  Fly   486 AKQIVTITQSRY-YQKYLDNSSNDCWWVPVAYIVR-----NLTLPQVEWLGCQKNSRDILELSH- 543

  Fly   568 LPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDY 632
            :..|:.|::.|...:.|.:|.||:.|.:|:.|.|. :|:..|..::|.||:||.|..:|:|...|
  Fly   544 IANPEDWLLINVDAAVPLRVFYDSYNLQLISEALR-QDFTQIPELSRIQLVDDALSLSWSGRLPY 607

  Fly   633 EIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYE-HLNGIN--- 693
            .:.|.|||||..|..:|.|::|..||:.:..|:|.|..||.||.:.::||.|.:: .||.::
  Fly   608 NVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKA 672

  Fly   694 -------------------------------------DTVASE---------EQQDKT------- 705
                                                 ||..|.         |..|.|
  Fly   673 RTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTK 737

  Fly   706 ---ILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDE--VNPVPLGIRGVVYCTAIKHGCDE 765
               .|.||:...||.||:.:|:|.|     ..|.:|..|:  .:.:|..||.:|.|..|::|.:.
  Fly   738 SDLSLSAILYRLACQFEIKECLTDA-----QQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEV 797

  Fly   766 DWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEV 830
            .|..:...:.::....|:.|:|:||.|:.|.|.:|:.|....|.. .:.:..:.|:..|:..|.:
  Fly   798 HWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSK-KVPRTMTASLLSAVLRSPL 861

  Fly   831 GFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDY----DEFMNFMASSKDQLKDI 891
            |:.:.|::|:|:...|.:     |:.:..:|.|....:.|:.::    |.....:.||      :
  Fly   862 GYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSS------M 915

  Fly   892 EQTISQSLETMLINVQWKERNYERFTRAI 920
            ...:|.:||:.|..|.|:...|....:||
  Fly   916 VSGLSSTLESGLDRVNWRNNLYFDLLKAI 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	132/476 (28%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	101/393 (26%)
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	134/482 (28%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	101/395 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020