DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11951 and Trhde

DIOPT Version :10

Sequence 1:NP_001350853.2 Gene:CG11951 / 43463 FlyBaseID:FBgn0039656 Length:842 Species:Drosophila melanogaster
Sequence 2:NP_001102461.1 Gene:Trhde / 366894 RGDID:728895 Length:1066 Species:Rattus norvegicus


Alignment Length:921 Identity:293/921 - (31%)
Similarity:482/921 - (52%) Gaps:73/921 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLS 86
            :...||...|:|..|::.:...:||   |.|:|.|.::|.....|..:.||:..:.::..::...
  Rat   178 WTQLRLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAED 239

  Fly    87 QIGGEETTENCITSTAVNPTHDFY----------ILNTCKELLAGQFYELSLPFSAKLQDQLAGY 141
            :..|           || |...|:          :||  :.|.|.:.|.|.:.::|.::::|.|:
  Rat   240 RAFG-----------AV-PVAGFFLYPQTQVLVVVLN--RTLDAQRHYNLKIIYNALIENELLGF 290

  Fly   142 YRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRP 206
            :|||||  :..|.|::.||||.|..||.||||||||.|||:|.|::.:...|..|||||| ||..
  Rat   291 FRSSYV--IHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSV 352

  Fly   207 HESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAI--DQCDYAAELGP 269
            .|. ..:|...|.::..||||.:|:::.:|:::.:|..:|.:.|.:|||:||  ...|||..:..
  Rat   353 FEE-DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITK 416

  Fly   270 KVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVA 334
            :::::||:.|.:.:.|||:|.:|||.....|||||||..|.|..:|..|..||.....:...::.
  Rat   417 RLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIV 481

  Fly   335 HELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLL-TIFRKDSLES 398
            ||:.|||||:|||..||.|:||.||||.|...:..:.::|.|...:...::::| .:...|.|.|
  Rat   482 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLAS 546

  Fly   399 SHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWE 463
            |||:|:.:...:.|.:.||.|:|:||:::|||:..|:|...|:.||:.||..:.|.||.:::||.
  Rat   547 SHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWN 611

  Fly   464 SLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKG- 527
            :|::|..:.|   |..||:.:||.||||.|||||.:..:.|:....|..:::.: .|:....|. 
  Rat   612 TLSEALKRNG---KYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFI-YDIGAKTKAL 672

  Fly   528 -------CWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQ--WVIFNNQLSA 583
                   .|.:||:.........::.| ..|:       |.....|.:...|:  |::.|...:.
  Rat   673 QLQNSSYLWQIPLTIVVGNRSHVSSEA-IIWV-------SNKSEHHRITYLDKGSWILGNINQTG 729

  Fly   584 PYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLEREREL 648
            .::||||.:||:|||:.| ..::..:.|.|||.||||....|..|.....|.|::|.||..|::.
  Rat   730 YFRVNYDLRNWRLLIDQL-IRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDF 793

  Fly   649 LPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL----NGINDTVASEEQQDKTILKA 709
            |||.:|...|..:..:|.:..|:..|..:..:.:...|..|    |..|.:|.....|.:.:.:.
  Rat   794 LPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEELRRE 858

  Fly   710 IVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDED-WDFLWTR 773
            ::. .||||....|..||.:....|.|...    |.:||.:|.:||||.:.. .||| |:|:|.:
  Rat   859 VIM-LACSFGNKHCHQQASTLISDWISSNR----NRIPLNVRDIVYCTGVSL-LDEDVWEFIWMK 917

  Fly   774 YQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKY 838
            :......:||:|:|::|.||.:..:|.|.|..:.:. ..:..||:..|...:|.:..|..||.|:
  Rat   918 FHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNS-EVVLDQDAIDVIIHVARNPHGRDLAWKF 981

  Fly   839 LMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETML 903
            ..|....::..|.......|:|:..::|.:.|:.:..|..||| .|.|.:  ...:.|:::||:.
  Rat   982 FRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM-KSYDGV--ASASFSRAVETVE 1043

  Fly   904 INVQWKERNYE 914
            .||:|| |.|:
  Rat  1044 ANVRWK-RLYQ 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11951NP_001350853.2 M1_APN-Q_like 35..490 CDD:341064 165/467 (35%)
ERAP1_C 574..902 CDD:463368 97/332 (29%)
TrhdeNP_001102461.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..177
M1_APN-Q_like 190..635 CDD:341064 165/468 (35%)
ERAP1_C 720..1044 CDD:463368 98/334 (29%)
Blue background indicates that the domain is not in the aligned region.

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