DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG40470

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	937	Identity:	243/937 - (25%)
Similarity:	424/937 - (45%)	Gaps:	75/937 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILAALGL-SFAGEGST---YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNT 66
            ::|.|.|| :|..:.|:   ....|||..:.|.||:|.|...::|.   :|.|::::.:..:.::
  Fly    28 ILLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHMDNQ---NFEGSIRMHLRWIGDS 89

  Fly    67 HNITLHSKD-LTIDDTEITLSQIG-GEETTE-NCITSTAVN-PTHDFYILNTCKELLAGQFYELS 127
            ..:..|:.| |.||.::|.|:.:. |:.|.: |.|....|. |....::|....::..|....|.
  Fly    90 KKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSECLLD 154

  Fly   128 LPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKK 192
            :.|...:.:...|.:||.|.|:..:.......|..:|..||..||||||||.|..|.:::...|.
  Fly   155 IYFQGNISETEEGLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKG 219

  Fly   193 YTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTY---LVAYSLNDFSH----KPSTLPNGTLFR 250
            |..|.|.|::.|..|..:..|....|..:.||||:   .|...|:.::.    |.|.:|   ...
  Fly   220 YITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIP---AIN 281

  Fly   251 TWAR----PNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAE 311
            .|:.    .|.:| ......:....::::   |.|..||.|:|.||:|..:.       |...:.
  Fly   282 IWSNNLSSTNLLD-IQNKLNVAHTTIQHF---FNIPLPLTKLDVIAIPSLAT-------LPFISA 335

  Fly   312 STLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQW 376
            |.:|.:.|  |:..|::...| :.||.:||.|..:|.:||||..:|:...:::||..|.:|:...
  Fly   336 SGILIARE--SEILKKDVFEI-SRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGI 397

  Fly   377 RTLQLESMSNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFR 441
            .......|:.|.:::.:  |...:|.|.    .:.|...|..|..|   .:|||:.|.:|:..||
  Fly   398 EFNGKYPMTILYSLYYE--LSKRYPNSH----ITGIKHEFASIKVQ---LIIRMLSLTVGKYTFR 453

  Fly   442 TGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSR 506
            .|::|::..|.:|..:..:.|.::|..|....||..|.:|.:|.:||...:..|::.:.|||.|.
  Fly   454 LGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSE 518

  Fly   507 TAKLSQERYLLNT--DVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLP 569
            ||.:.|:.||...  ||.......||:|::...|:...|.||...:||..|.     ...|.:||
  Fly   519 TAIVQQKVYLRERLHDVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTR-----QMLISNLP 578

  Fly   570 GPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSED-YHSIHVVNRAQLIDDVLYFAWTGEQDYE 633
            ..:.::|.|.:...|:.||||..||.:|.:.|.:|: ..||.|..||:|:.|....|:.||.::.
  Fly   579 SKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFS 643

  Fly   634 IALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVAS 698
            .||.|..:|:.||..:.|...|..|..|...|.::...:.|:.:...|:.|:||:|.    |...
  Fly   644 TALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLG----TAHF 704

  Fly   699 EEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGC 763
            .|..:.|.|:.:...:.|......|..:|...:..|.:.:.|:...|||    ....|:..|.|.
  Fly   705 NEDINITELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVP----NEYICSIFKWGS 765

  Fly   764 DEDWDFLWTR---YQKANVATEKQIILDSL-GC---SQEVWV-LQRYLERNFDGMGDIRKQDSTS 820
            .::|.|...|   :.|:.:.:::..:|..| ||   ..:::: |:..:.:|.....|   .|...
  Fly   766 MKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSD---TDKML 827

  Fly   821 VFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSK 885
            :...:....:|:.....:|.:|.|.|...::..:...::|:...:....||..||....|.....
  Fly   828 IISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHY 892

  Fly   886 DQLKDIEQTISQSLETMLINVQWKERN 912
            ......:..|.:||..:...:||.::|
  Fly   893 GHFGRAQHIIEKSLRNIKEGIQWSKQN 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	125/469 (27%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	80/336 (24%)
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	125/471 (27%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	78/332 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020