DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG31445

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	610/926 - (65%)
Similarity:	752/926 - (81%)	Gaps:	3/926 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKCVFLILAALG--LSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVL 63
            ||...|.:.|:|  ||.|...|.|:|:|||||||||.|.:||||.||:|||..|.|.|:|.|:.|
  Fly     1 MKWFLLFVLAIGLDLSVANSISRYNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKAL 65

  Fly    64 QNTHNITLHSKDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSL 128
            |||.|||||||:||||::.|||.||.|....:||::||:||||||:||.:||||||||..|:|.|
  Fly    66 QNTRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELLAGNVYKLFL 130

  Fly   129 PFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKY 193
            ||||.|..||.|||||||.:.|.|:|||:|.|||||::||.|||||||||:||||.:||||||::
  Fly   131 PFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQF 195

  Fly   194 TGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAI 258
            ..||||||.|.|||||:.:|:|..|:||:||||||||||:||||.||||||||.|||||||||||
  Fly   196 NALSNMPVREIRPHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGALFRTWARPNAI 260

  Fly   259 DQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQ 323
            ||||||||.|||||:||||.|||::||||:||:||||||||||||||||.:.||||||||.:||.
  Fly   261 DQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSL 325

  Fly   324 EAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLL 388
            ..||:.||::||||||||||||||||||||||||||||||||.|.|::|:|:|.:....|::.|:
  Fly   326 ADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALM 390

  Fly   389 TIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTY 453
            |.||.|||.|||||||||:|.::|.||||.|||||||:|:||||||:|||:|||||:.||:.|.|
  Fly   391 TAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAY 455

  Fly   454 KNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN 518
            |||||:|||||||.|||:.|:||..|:|.|||||||||||:||:|:||||::.||:::|||||.|
  Fly   456 KNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYLRN 520

  Fly   519 TDVSRAHK-GCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLS 582
            :.:.:|.: ||||||||||.|:|.|||||:||.||||:.|.|.||.||....||::|:|.|.|||
  Fly   521 SQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILNIQLS 585

  Fly   583 APYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERE 647
            .|||.||||:||||||:||||:|:.||||:|||||||||||||||||||||.||||.:||.|||:
  Fly   586 TPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNYLRRERD 650

  Fly   648 LLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVA 712
            |:|||||.|||:.::.||||||||..||.:.::|:|||||||:|:|||.:...|||:.:||..|.
  Fly   651 LIPWKSALDNLKLLNRILRQTPNFGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEVLLKTTVV 715

  Fly   713 DWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKA 777
            :.||.::||||||||.:::|.||:|.||||.:||||.:|..||||||..|.:|||:|||:||:|:
  Fly   716 NVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKS 780

  Fly   778 NVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDN 842
            |||:|:|.||.:||||:|||:||||:|::|.....||||||:..|||:|..||||||||:|.::|
  Fly   781 NVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLLAKQYFIEN 845

  Fly   843 VDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQ 907
            |:.|.|:|:||:..||.||.|||||:.|..|.::|.:|...|:..||.|.|.:.|||||||.|||
  Fly   846 VELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLKGIRQAMQQSLETMLTNVQ 910

  Fly   908 WKERNYERFTRAISKH 923
            |.:.||.:|:|.|..|
  Fly   911 WMDWNYHKFSRTIRHH 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	323/454 (71%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	202/327 (62%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	284/397 (72%)
		M1_APN_2	43..497	CDD:189008	325/453 (72%)
		ERAP1_C	578..904	CDD:288671	200/325 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H114373
Inparanoid	1	1.050	913	1.000	Inparanoid score	I1106
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	10	9.970