DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG31343

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	288/940 - (30%)
Similarity:	469/940 - (49%)	Gaps:	94/940 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHS 73
            |||..:...:.::..::|||....|:||:|.:.|.:.| .|..|||||.|.|.||..|.|||||.
  Fly    40 AALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHN-GDTEFNGTVNIDIRVLNETSNITLHY 103

  Fly    74 KDLTIDDTEITLSQIGGEETTENCITSTAVNP--THDFYILNTCKELLAGQFY------ELSLPF 130
            :..:  :.|.|:  |..:..|...|..| |.|  ..:|.:|.   :..||:.:      .:::.:
  Fly   104 RQTS--NFEATI--ISRDVATPTAIPLT-VTPELQREFLVLT---QTTAGEAFGANTNWTITINY 160

  Fly   131 SAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTG 195
            :...:..:.|:|.|||.:. ..|..:::.||||...||.||||:|||..:|:|.||:.:...||.
  Fly   161 TGIHRSDMGGFYISSYTDD-DGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTA 224

  Fly   196 LSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQ 260
            :||||||.......:     |:|:.:..|||||||:.::||......| ||...|.::|....||
  Fly   225 ISNMPVNTAATSSGV-----TAFQTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKGKQDQ 283

  Fly   261 CDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEA 325
            .::|...|..|.......||:.|.|||:||..:|||||||||||||.|:.|..:.::.:.|:...
  Fly   284 QEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINL 348

  Fly   326 KQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTI 390
            |...|||:.||.||.|||:||::||||.|||.|||||..:....:...|.|.|.|:..:::..:.
  Fly   349 KTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSA 413

  Fly   391 FRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKN 455
            ...|:|.|:.|::..::..|:||..::..||.|.:||:.|......::.|||||..||.|..|.:
  Fly   414 LLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTS 478

  Fly   456 AEQDNLWESLTQAAHKTG-SLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN- 518
            .::.:|:.|..::|.:.| :||.  ::..|..||:.|.|||::.|||:|.:.|..::|:||:.|
  Fly   479 CDEWDLFASFQESADELGFTLPA--SVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANK 541

  Fly   519 TDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEW-MECTETGESVPKTIHDL-PGPDQWVIFNNQL 581
            ||.:.|   .|:|||::....:.|:.:|:...: :..|||      .|.|: ...|.|:|.|.|.
  Fly   542 TDTNSA---TWYVPLNFATANKYDYRDTSATHYLLNVTET------VISDVEASSDDWIIVNIQN 597

  Fly   582 SAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERER 646
            |..|:..||.||:.|:...|.|:.:. .|..|||||:.|...|..|....:.|.|:::.||..|:
  Fly   598 SGYYRTLYDTQNYGLITAALKSQPWR-FHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQ 661

  Fly   647 ELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIV 711
            :..||.:|...|......||...::..|::|.:|||.||::.: |:|:...  |......|:.::
  Fly   662 QYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKI-GVNEIPG--EHYLNNYLRIVL 723

  Fly   712 ADWACSFEVSDCVTQALS-----FYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLW 771
            ...||.....||..|:.:     .|.....||.          ::...||..::...:|.:..:.
  Fly   724 VSLACQVGSDDCYNQSANKLSEYLYNGTAIEAT----------LKTQAYCAGLRSTTNEIYSRVQ 778

  Fly   772 TRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVF-QAIADSEVGFLLA 835
            :....::.:|::.:.:.|||||.....|..:|..:.|....:...:.||:. .|.:.||:|...:
  Fly   779 SDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTAS 843

  Fly   836 KKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLK----------- 889
            .::|..|.::.:        ::|:...||...:      .....::.|.|.:.:
  Fly   844 LEFLESNWEAYA--------NLSDSAKPLDAAL------RGIATYVVSEKQKTRLNALVDVVEAD 894

  Fly   890 -------DIEQTISQSLETMLINVQWKERN 912
                   |:..||...:.:   |..|.|.|
  Fly   895 GPSYINDDLSTTIDSRITS---NFAWLEVN 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	169/463 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	80/351 (23%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	151/404 (37%)
		M1_APN_2	65..517	CDD:189008	171/469 (36%)
		ERAP1_C	591..886	CDD:288671	76/322 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020