DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and lnpep

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	930	Identity:	299/930 - (32%)
Similarity:	469/930 - (50%)	Gaps:	105/930 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKD 75
            :|.:||...:...|||.::.|..|::.:     :||  ...|.|.|.|.:.|:..|.||.|||.|
Zfish   164 ISTSGELFPWTDLRLPVSVHPVHYNISL-----HPDLNSMTFQGNVSIVVLVMHETKNIILHSSD 223

  Fly    76 L-----TIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQ 135
            :     |.||.|....:               ..|.....| ...::|..|| |.|...:.|.|.
Zfish   224 MNIIKVTFDDKEYRFLE---------------YKPWQQIAI-KFPEDLKKGQ-YVLKFSYKANLS 271

  Fly   136 DQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMP 200
            :...|:|.||||:| |...|.::.|||||.|||.||||||||.:|::|.:.:....||..|||||
Zfish   272 NSYDGFYNSSYVDT-AGTKRVLAATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKYISLSNMP 335

  Fly   201 ------VNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAID 259
                  :||....|.       .||.|:.|||||||:.:.:||.....:...|: ..:|.|:..|
Zfish   336 KIKTTDLNENGLQED-------EFESSVKMSTYLVAFIVAEFSSHSKNVSKTTV-SVYAVPDKKD 392

  Fly   260 QCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQE 324
            |..||.|...|:||:|...|.|::||.|:|.:|:|||.|||||||||:||.|:|||...: ||:.
Zfish   393 QVHYALETACKLLKFYNTFFEIEYPLSKLDLVAIPDFLAGAMENWGLITFRETTLLVGNQ-SSRF 456

  Fly   325 AKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLT 389
            .||...:::|||||||||||||||:||.|||||||||||:..:.:|::.|. ..:.:|.::....
Zfish   457 DKQLVTSVIAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPD-LDIDIEFLNVRFK 520

  Fly   390 IFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYK 454
            ...||:|.||||:|..:....|:.|.||.:||:||:|::.|::..|.:..|..|:..||:.|...
Zfish   521 ALAKDALNSSHPVSTFVSTPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHKGVIEYLQNYNLS 585

  Fly   455 NAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNT 519
            |.|..:||.||:|.:.::      .|:..:|::||:..|:|::.|.|:....|  ||||.:|||.
Zfish   586 NTESKDLWNSLSQVSKQS------LNVSEMMNTWTVHKGFPLVTVKRNGPQVT--LSQEHFLLNA 642

  Fly   520 DVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIH--------DLPGPDQWVI 576
            :........|.:||:|.|.              .|:.. .|..:..|        .|||..:|:.
Zfish   643 ENGTDDSSLWHIPLTYVND--------------SCSVL-RSCKQVFHLKDKEATLQLPGQVKWLK 692

  Fly   577 FNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISY 641
            ||.:....|.|:||.|.|..||..| ..|.:.:...::|.||:::...:..|:..:...|.::.|
Zfish   693 FNFRSDGFYIVHYDEQGWSDLISAL-KVDVNVLPSEDKAALINNIFALSRLGKVSFRQVLNLMDY 756

  Fly   642 LERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQ--DK 704
            :..|.|..|...|...|..:..:|.:..:.    |....:.|.|..|...:.::.:.|.:.  .|
Zfish   757 IRNETETAPLTEALSQLGQIYRLLDKRSDL----NLASSMTTYIESHFGSLMESQSWEVETSVSK 817

  Fly   705 TILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDF 769
            ..|::.:.:.||:....:|.|||...:..|.:.   ::...:|..:...|:..|.|  .||.|..
Zfish   818 MTLRSALLETACALNRPNCTTQARRLFDQWLAS---NKTLQIPSDLMRTVFKVAAK--TDEGWSK 877

  Fly   770 LWTRYQKANVATEKQIILDSLGCSQEV----WVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEV 830
            |...|:.:...|||:.:|::|..:|:|    ||||:.|    || .:|:.|:...|...:.....
Zfish   878 LLGSYKHSIYDTEKRKMLEALASTQDVRKIIWVLQKSL----DG-SEIQNQEFPLVIHTVCRDFA 937

  Fly   831 GFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMAS---SKDQLKDIE 892
            |:|.|..::.:|.:.|::.:...|.::..::...:.|..|:....|..||.:|   ...|::.::
Zfish   938 GYLYAWDFMKENWEKITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQNFFSSLGAKGSQMRIVQ 1002

  Fly   893 QTISQSLETMLINVQWKERN 912
            :.|    ||:..|::|.|:|
Zfish  1003 EAI----ETIKHNMRWMEKN 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	183/467 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	80/336 (24%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	185/473 (39%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	81/337 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920