Protein Alignment CG11951 and TRHDE

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_037513.2
• Gene: TRHDE / 29953
• HGNCID: 30748
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 289/916 - (31%)
• Similarity: 478/916 - (52%)
• Gaps: 72/916 - (7%)

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLS 86
            :...||...|:|..|::.:...:||   |.|:|.|.::|.....|..:.||:..:.::..::...
Human   181 WTQLRLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAED 242

  Fly    87 QIGGEETTENCITSTAVNPTHDFY----------ILNTCKELLAGQFYELSLPFSAKLQDQLAGY 141
            :..|           || |...|:          :||  :.|.|.:.|.|.:.::|.::::|.|:
Human   243 RAFG-----------AV-PVAGFFLYPQTQVLVVVLN--RTLDAQRNYNLKIIYNALIENELLGF 293

  Fly   142 YRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRP 206
            :|||||  :..|.|::.||||.|..||.||||||||.|||:|.|::.:...|..|||||| ||..
Human   294 FRSSYV--LHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSV 355

  Fly   207 HESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAI--DQCDYAAELGP 269
            .|. ..:|...|.::..||||.:|:::.:|:::.:|..:|.:.|.:|||:||  ...|||..:..
Human   356 FEE-DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITK 419

  Fly   270 KVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVA 334
            :::::||:.|.:.:.|||:|.:|||.....|||||||..|.|..:|..|..||.....:...::.
Human   420 RLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIV 484

  Fly   335 HELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLL-TIFRKDSLES 398
            ||:.|||||:|||..||.|:||.||||.|...:..:.::|.|...:...::::| .:...|.|.|
Human   485 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLAS 549

  Fly   399 SHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWE 463
            |||:|:.:...:.|...||.|:|:||:::|||:..|:|...|:.||:.||..:.|.||.:::||.
Human   550 SHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWN 614

  Fly   464 SLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKG- 527
            :|::|..:.|   |..||:.:||.||||.|||||.:..:.|:....:..:::.: .|:|...|.
Human   615 TLSEALKRNG---KYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFI-YDISAKTKAL 675

  Fly   528 -------CWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQ--WVIFNNQLSA 583
                   .|.:||:.........::.| ..|:       |.....|.:...|:  |::.|...:.
Human   676 KLQNNSYLWQIPLTIVVGNRSHVSSEA-IIWV-------SNKSEHHRITYLDKGSWLLGNINQTG 732

  Fly   584 PYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLEREREL 648
            .::||||.:||:|||:.| ..::..:.|.|||.||||....|..|.....|.|::|.||..|::.
Human   733 YFRVNYDLRNWRLLIDQL-IRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDF 796

  Fly   649 LPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL----NGINDTVASEEQQDKTILKA 709
            |||.:|...|..:..:|.:..|:..|..:..:.:...|..|    |..|.::.....|.:.:.:.
Human   797 LPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 861

  Fly   710 IVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDED-WDFLWTR 773
            ::. .||||....|..||.:....|.|...    |.:||.:|.:||||.:.. .||| |:|:|.:
Human   862 VIM-LACSFGNKHCHQQASTLISDWISSNR----NRIPLNVRDIVYCTGVSL-LDEDVWEFIWMK 920

  Fly   774 YQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKY 838
            :......:||:|:|::|.||.:..:|.|.|..:.:. ..:..||:..|...:|.:..|..||.|:
Human   921 FHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNS-EVVLDQDAIDVIIHVARNPHGRDLAWKF 984

  Fly   839 LMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETML 903
            ..|....::..|.......|:|:..::|.:.|:.:..|..|||   |:.......:.|:::||:.
Human   985 FRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM---KNYDGVAAASFSRAVETVE 1046

  Fly   904 INVQWK 909
            .||:||
Human  1047 ANVRWK 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	165/467 (35%)
		ERAP1_C	574..902	CDD:463368	95/332 (29%)
TRHDE	NP_037513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..179
		M1_APN-Q_like	193..638	CDD:341064	165/468 (35%)
		ERAP1_C	723..1047	CDD:463368	96/334 (29%)