DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Aopep

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_008769651.1	Gene:	Aopep / 290963	RGDID:	1309592	Length:	886	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	140/728 - (19%)
Similarity:	243/728 - (33%)	Gaps:	236/728 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NCITSTAVNPTHDFYILNTCKELL------AGQFYELSLPFSAKLQDQLAGYYRS-----SYVNT 149
            :|.|..:..|        .|.|||      :.|..:..:|.:|.....:..:|::     |...|
  Rat   268 DCYTRCSQAP--------GCGELLFDSDKWSLQIRKKGVPTAADFPHAIRIWYKTKPEGQSVTWT 324

  Fly   150 VANETRWISVTQFEPAAARLAFPCFDEP----------GYKASFAITLGYHKKYTGLSNMPVNET 204
            ...:.|....|...|...|..|||.:.|          ...|||.:.:...|           ..
  Rat   325 SDQDGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEK-----------SA 378

  Fly   205 RPHESIPDYVWTSFEESLPM--STYLVAYSL-NDFSHKPSTLPNGTLFRTWARPNAID------- 259
            :|......|:...:..::||  ||:.:|... .:...|.|.|.:.|......||:..|
  Rat   379 KPTPLREGYMSWHYYVTMPMPASTFTIAVGCWTEMKPKTSPLDDLTEHTLPLRPSDADFRYGNTC 443

  Fly   260 -----QCDYAAE----------------------------LGPKVLKYYEELFGIKFPLPKVDQI 291
                 .|.:.:.                            |.|..|.....:.| ..|..::|.:
  Rat   444 SHMEYPCRFQSASAATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLG-THPFSRLDIL 507

  Fly   292 AVP-DFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLW 355
            .|| :|.:..|.:..::..::|||..:.......        :.||:||.|||..:..:.||:.|
  Rat   508 IVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTR--------LCHEIAHAWFGLAIGARDWTEEW 564

  Fly   356 LNEGFATYVASLCVEDIH-------PQWRTLQLESMSNLLTIFR-KDSLESS---HPISRP-IEM 408
            |:|||||:     :|||.       |....|:.:.:...|...| :|.|::|   ..:.|| .|.
  Rat   565 LSEGFATH-----LEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEK 624

  Fly   409 TSQISES--------------FDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQD 459
            |..:|.|              |.::.|.||..::|.:...||||.:...|:.::..:..:.....
  Rat   625 TGHVSASGASVVKNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLFHGQLILSQ 689

  Fly   460 NLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRA 524
            :..:.|.:      |:|::...           |..|.|:..|:..
  Rat   690 DFLQMLLE------SIPENKRF-----------GLSVENIVGDWLE------------------- 718

  Fly   525 HKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPK--TIHDLPG---------------PD 572
               |..:|.:.  |||:...:.:|...:.  :.|..|.|  .::..||               ||
  Rat   719 ---CPGIPKAL--QEERKAKDCSPSRLVR--QVGSEVAKWIRVNRRPGKRQRRKREAAFEKLSPD 776

  Fly   573 QWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQ 637
            |.|:.              ..|.|..:||:.:..|.:......|            |||.|:
  Rat   777 QIVLL--------------LEWLLEQKTLSPQTLHRLQQTYHLQ------------EQDAEV--- 812

  Fly   638 VISYLERER--ELL---PWKSAFDNLQ-----------FVSGILRQTPNFRFFKNFTRRLITPIY 686
                  |.|  ||:   .:..|:|.::           ::.|.|..:.:.| .:....|....:.
  Rat   813 ------RHRWCELVIKHKYTKAYDQVKRFLQEDQAMGIYLYGELMVSEDAR-LQQLAHRCFELVK 870

  Fly   687 EHLNGINDTVASE 699
            .|::..:..|.:|
  Rat   871 GHMDKASAQVVTE 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	98/484 (20%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	24/142 (17%)
Aopep	XP_008769651.1	GluZincin	250..697	CDD:301352	96/461 (21%)
Aopep	XP_008769651.1	Leuk-A4-hydro_C	743..884	CDD:286244	32/177 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910