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Protein Alignment CG11951 and ANPEP

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	931	Identity:	323/931 - (34%)
Similarity:	496/931 - (53%)	Gaps:	75/931 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EGSTYDHFRLPTALRPQSYDVRILTQLENPDD---FHFNGTVKIQIEVLQNTHNITLHSKDLTID 79
            :...::.:|||..|:|.||.|.:...| .|:|   :.|.|:..::....:.|..|.:|||.|
Human    67 QSKAWNRYRLPNTLKPDSYRVTLRPYL-TPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKL--- 127

  Fly    80 DTEITLSQ--------IGGEETTENCITST-AVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQ 135
              ..||||        :||.:..:  |..| .|.|| ::.:::....|:....||:...|..:|.
Human   128 --NYTLSQGHRVVLRGVGGSQPPD--IDKTELVEPT-EYLVVHLKGSLVKDSQYEMDSEFEGELA 187

  Fly   136 DQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNM- 199
            |.|||:|||.|:.  .|..:.::.||.:.|.||.:|||||||..||.|.|||.:.|..|.||||
Human   188 DDLAGFYRSEYME--GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNML 250

  Fly   200 PVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAI--DQCD 262
            |...:.|....|::..|.|..:..|||||:|:.:::|.:......||.|.|.||||:||  ...|
Human   251 PKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGD 315

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            ||..:...:|.::...:...:||||.|||.:|||:|||||||||||:.|::||:.|..||...|:
Human   316 YALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKE 380

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ....::||||||||||||||::||.|||||||||:||..|..:...|.|....|..::::..:..
Human   381 RVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMA 445

  Fly   393 KDSLESSHPISRP---IEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYK 454
            .|:|.||||:|.|   |...:||||.||.|||.||:||:||:..||.|:.|:.||.|||..:.|:
Human   446 VDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQ 510

  Fly   455 NAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNT 519
            |....|||:.|.:|.:.. |:.....::.||:.||||.|:|||.|    .:.|..||||.:||:.
Human   511 NTIYLNLWDHLQEAVNNR-SIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFLLDP 570

  Fly   520 D--VSRAHK--GCWWVPLS--YTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFN 578
            |  |:|..:  ..|.||::  ...::::|:       |:........:..|     ..::||:.|
Human   571 DSNVTRPSEFNYVWIVPITSIRDGRQQQDY-------WLIDVRAQNDLFST-----SGNEWVLLN 623

  Fly   579 NQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLE 643
            ..::..|:||||.:||: .|:|....|:.:|.|:||||:|:|....|...:....:||....:|.
Human   624 LNVTGYYRVNYDEENWR-KIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLI 687

  Fly   644 RERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL-NGINDTVASEEQQDKTIL 707
            .||:.:||::|..:|.:...:..::..:...||:.::.:||::.|. |..|:.....|.......
Human   688 EERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYS 752

  Fly   708 KAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWT 772
            :......|||..|.:|.......::.|..  ||:. ||:...:|..|||.||..|.:|:|||.|.
Human   753 EVNAISTACSNGVPECEEMVSGLFKQWME--NPNN-NPIHPNLRSTVYCNAIAQGGEEEWDFAWE 814

  Fly   773 RYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGD-IRKQDSTSVFQAIADSEVGFLLAK 836
            :::.|.:..|...:..:|.||:|:|:|.|||....:  .| |||||:||...:|.::.:|..|..
Human   815 QFRNATLVNEADKLRAALACSKELWILNRYLSYTLN--PDLIRKQDATSTIISITNNVIGQGLVW 877

  Fly   837 KYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQT------- 894
            .::..|...:...|...|.|.|.|:..::.:..|:.:..:...|.       ||.|:|
Human   878 DFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFK-------KDNEETGFGSGTR 935

  Fly   895 -ISQSLETMLINVQWKERNYE 914
             :.|:||....|::|.:.|.|
Human   936 ALEQALEKTKANIKWVKENKE 956

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.