DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Trhde

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	921	Identity:	292/921 - (31%)
Similarity:	481/921 - (52%)	Gaps:	73/921 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLS 86
            :...||...|:|..|::.:...:||   |.|:|.|.::|.....|..:.||:..:.::..::...
Mouse   178 WTQLRLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAED 239

  Fly    87 QIGGEETTENCITSTAVNPTHDFY----------ILNTCKELLAGQFYELSLPFSAKLQDQLAGY 141
            :..|           || |...|:          :||  :.|.|.:.|.|.:.::|.::::|.|:
Mouse   240 RAFG-----------AV-PVAGFFLYPQTQVLVVVLN--RTLDAQRHYNLKIIYNALIENELLGF 290

  Fly   142 YRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRP 206
            :|||||  :..|.|::.||||.|..||.||||||||.|||:|.|::.:...|..|||||| ||..
Mouse   291 FRSSYV--IHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSV 352

  Fly   207 HESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAI--DQCDYAAELGP 269
            .|. ..:|...|.::..||||.:|:::.:|:::.:|..:|.:.|.:|||:||  ...|||..:..
Mouse   353 FEE-DGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITK 416

  Fly   270 KVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVA 334
            :::::||:.|.:.:.|||:|.:|||.....|||||||..|.|..:|..|..||.....:...::.
Mouse   417 RLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIV 481

  Fly   335 HELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLL-TIFRKDSLES 398
            ||:.|||||:|||..||.|:||.||||.|...:..:.::|.|...:...::::| .:...|.|.|
Mouse   482 HEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLAS 546

  Fly   399 SHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWE 463
            |||:|:.:...:.|...||.|:|:||:::|||:..|:|...|:.||:.||..:.|.||.:::||.
Mouse   547 SHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWN 611

  Fly   464 SLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKG- 527
            :|::|..:.|   |..||:.:||.||||.|||||.:..:.|:....|..:::.: .|:....|.
Mouse   612 TLSEALRRNG---KYVNIQEVMDQWTLQMGYPVITILGNTTAENRILITQQHFI-YDIGAKTKAL 672

  Fly   528 -------CWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQ--WVIFNNQLSA 583
                   .|.:||:.........::.| ..|:       |.....|.:...|:  |::.|...:.
Mouse   673 QLQNSSYLWQIPLTIVVGNRSHVSSEA-IIWV-------SNKSEHHRIAYLDRGSWILGNINQTG 729

  Fly   584 PYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLEREREL 648
            .::||||.:||:|||:.| ..::..:.|.|||.||||....|..|.....|.|::|.||..|::.
Mouse   730 YFRVNYDLRNWRLLIDQL-IRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDF 793

  Fly   649 LPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL----NGINDTVASEEQQDKTILKA 709
            |||.:|...|..:..:|.:..|:..|..:..:.:...|..|    |..|.::.....|.:.:.:.
Mouse   794 LPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEELRRE 858

  Fly   710 IVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDED-WDFLWTR 773
            ::. .||||....|..||.:....|.|...    |.:||.:|.:||||.:.. .||| |:|:|.:
Mouse   859 VIM-LACSFGNKHCHQQASTLISDWISSNR----NRIPLNVRDIVYCTGVSL-LDEDVWEFIWMK 917

  Fly   774 YQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKY 838
            :......:||:|:|::|.||.:..:|.|.|..:.:. ..:..||:..|...:|.:..|..||.|:
Mouse   918 FHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNS-EVVLDQDAIDVIIHVARNPHGRDLAWKF 981

  Fly   839 LMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETML 903
            ..|....::..|.......|:|:..::|.:.|:.:..|..||| .|.|.:  ...:.|:::||:.
Mouse   982 FRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM-KSYDGV--ASASFSRAVETVE 1043

  Fly   904 INVQWKERNYE 914
            .||:|| |.|:
Mouse  1044 ANVRWK-RFYQ 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	165/467 (35%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	96/332 (29%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	165/468 (35%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	97/334 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020