Protein Alignment CG11951 and ENPEP

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Alignment Length: 945
• Identity: 295/945 - (31%)
• Similarity: 472/945 - (49%)
• Gaps: 134/945 - (14%)

  Fly    18 EGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTE 82
            |...:.:||||..:.|..||:.:...||...   :.|||.|.|.:...|..:.||     :.:|.
Human    84 ESGQWKNFRLPDFVNPVHYDLHVKPLLEEDT---YTGTVSISINLSAPTRYLWLH-----LRETR 140

  Fly    83 IT----LSQIGGEET-TENCITSTAVNPTHDFYILNTCKELLAGQ---FYELSLPFSAKLQDQLA 139
            ||    |.:..|::. ...|..    ....::.::...:||....   .|.|::.|:..|...|.
Human   141 ITRLPELKRPSGDQVQVRRCFE----YKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLV 201

  Fly   140 GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNET 204
            |:||::|  |...:.:.|..|..||..||.:|||||||..||::.|::.:.|:|..||||||.:
Human   202 GFYRTTY--TENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAK- 263

  Fly   205 RPHESIPD-YVWTSFEESLPMSTYLVAYSLNDF--------SHKPSTLPNGTLFRTWARPNAIDQ 260
              .||:.| :..|:||:|:|||||||.::::.|        |.||.|:        :.:|.....
Human   264 --EESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTI--------YVQPEQKHT 318

  Fly   261 CDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEA 325
            .:|||.:...|..|:||.|.:.:.|||:|:||:|||..||||||||:|:.|:.|||.|:.|:...
Human   319 AEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSN 383

  Fly   326 KQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTI 390
            :|..|.:|||||.||||||:|||.||.|||||||||::...|.|......|:......:.::|.:
Human   384 QQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPV 448

  Fly   391 FRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKN 455
            ...|||.|||||...:....:|:..||.|||.||||::||:..::..|.|:.|.:.|||||.:||
Human   449 QEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKN 513

  Fly   456 AEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTD 520
            |:..:.|.:|.:|:.    ||    :|.:||:||.|.||||:||     :....::|:|:||:
Human   514 AKTSDFWAALEEASR----LP----VKEVMDTWTRQMGYPVLNV-----NGVKNITQKRFLLD-- 563

  Fly   521 VSRAHKG--------CWWVPLSYT----------NQEEKD---FNNTAPKEWMECTETGESVPKT 564
             .||:..        .|.:|:.:|          |:.||:   .|::.|        :|.:..|.
Human   564 -PRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNP--------SGNAFLKI 619

  Fly   565 IHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGE 629
                 .||. :.|       |:|||:...|. .|.|..|.::.:....:||.||||....|....
Human   620 -----NPDH-IGF-------YRVNYEVATWD-SIATALSLNHKTFSSADRASLIDDAFALARAQL 670

  Fly   630 QDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPN-FRFFKNFTRRLITPIYEHL--NG 691
            .||::||.:..||:||...|||:.....:.::..:...... :...:.:.:..:.||.:.|  |.
Human   671 LDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWND 735

  Fly   692 INDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVN---PVPLGIRGV 753
            ..|.|..       :|::.|..:||.....:.:..|.|.:..|        :|   .:|:.:|.:
Human   736 AGDHVTK-------LLRSSVLGFACKMGDREALNNASSLFEQW--------LNGTVSLPVNLRLL 785

  Fly   754 VYCTAIKHGCDE-DWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGD---IR 814
            ||...:::..:| .|::...:|||.::|.||:.:|..|...:.|.:|.|||    |.:.|   |:
Human   786 VYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYL----DLLKDTNLIK 846

  Fly   815 KQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMN 879
            .||..:|.:.|:.:..|..:|..::..|.|.:...|...:.::..:: .::|...|:....:..:
Human   847 TQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIV-TIAEPFNTELQLWQMES 910

  Fly   880 FMASSKDQLKDIEQTISQSLETMLINVQW--KERN 912
            |.| ...|....|:...|.|||:..|::|  :.||
Human   911 FFA-KYPQAGAGEKPREQVLETVKNNIEWLKQHRN 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	177/471 (38%)
		ERAP1_C	574..902	CDD:463368	81/337 (24%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	177/472 (38%)
		ERAP1_C	616..934	CDD:463368	85/352 (24%)