Protein Alignment CG11951 and Npepps

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_032968.2
• Gene: Npepps / 19155
• MGIID: 1101358
• Length: 920
• Species: Mus musculus
• Alignment Length: 920
• Identity: 294/920 - (31%)
• Similarity: 450/920 - (48%)
• Gaps: 70/920 - (7%)

  Fly     8 LAALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNIT 70
            |.:|||:...|...::  |||..:.|.:|.:.:     .||  ||.|.|.::...:|.|.|:.|.
Mouse    38 LHSLGLAAMPEKRPFE--RLPAEVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQIV 95

  Fly    71 LHSKDLTIDDTEITLSQI--GGEETTENCITSTAVN-PTHDFYILNTCKELLAGQFYELSLPFSA 132
            ::..|:.|    ||.|..  |.||     |.:|..| ...|..:..:....|......|.:.|..
Mouse    96 MNCADIDI----ITASYAPEGDEE-----IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 151

  Fly   133 KLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLS 197
            :|.|::.|:|||.| .|.|.|.|:.:|||||...||.||||:|||..||:|.|:|...|....||
Mouse   152 ELNDKMKGFYRSRY-TTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 215

  Fly   198 NMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCD 262
            ||.|.:.:|:....:.|...|..:..|||||||:.:.::....:...:|...|.:......:|..
Mouse   216 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 280

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            :|.|:..|.|.:|::.|.:.:||||:|.||:.||:|||||||||||:.|:.||..|:.|...::|
Mouse   281 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 345

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ..|.:|.||||||||||||||:|||.||||||||:::..|||:...|::........::......
Mouse   346 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 410

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            .|:|::||||...:...|::.|.||.|||.||:|||||:|.::|::.|:.|:..||.|:..|||.
Mouse   411 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 475

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYT--SRTAKLSQERYLLNTD 520
            .::|||||..|:.|.        |..:|::||.|.|:|:|.|..:..  .|..||||:::..:..
Mouse   476 TEDLWESLESASGKP--------IAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGP 532

  Fly   521 VSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPY 585
            ........|.||::.:..|  |.|....|..|:..|. ..|.|.:.    |||||..|......|
Mouse   533 YGGEDCPQWMVPITISTSE--DPNQAKLKILMDKPEM-SVVLKNVK----PDQWVKLNLGTVGFY 590

  Fly   586 KVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLP 650
            :..|.:...:.|:..:..   .|:..|:|..|.:|:...|..|.......|:|:.....|.....
Mouse   591 RTQYSSAMLESLLPGIRD---LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTV 652

  Fly   651 WKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIV---- 711
            |.....||..:|.:|..|..:...:.|.:.:.:||.|.|..  |....|...| .:|:.:|
Mouse   653 WSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGW--DPKPGEGHLD-ALLRGLVLGKL 714

  Fly   712 --ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRY 774
              |....:.|.:         .|.::......::  :...:|..||.|.:|||.....|.:...:
Mouse   715 GKAGHKATLEEA---------RRRFKEHVEGKQI--LSADLRSPVYLTVLKHGDGATLDIMLKLH 768

  Fly   775 QKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLLAKKY 838
            ::|::..||..|...||.:....::|:.|  .|....::|.||:.||...:| .|:.|...|.|:
Mouse   769 KQADMQEEKNRIERVLGATLSPELIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKF 831

  Fly   839 LMDNVDSISKFYHPQSESMSELLPPLSEQIF-TQRDYDEFMNFMASSKDQLKDIEQTISQSLETM 902
            :.||.:.:...|  |...:...|..||.:.| ..:...|...|..|  ......|:||.|..|.:
Mouse   832 IKDNWEELHNRY--QGGFLISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQCCENI 892

  Fly   903 LINVQWKERN 912
            |:|..|.:|:
Mouse   893 LLNAAWLKRD 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	178/459 (39%)
		ERAP1_C	574..902	CDD:463368	78/335 (23%)
Npepps	NP_032968.2	M1_APN-Q_like	62..500	CDD:341064	178/460 (39%)
		ERAP1_C	579..892	CDD:463368	78/335 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)