DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and T12E12.6

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_500831.2	Gene:	T12E12.6 / 188454	WormBaseID:	WBGene00020465	Length:	641	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	164/717 - (22%)
Similarity:	270/717 - (37%)	Gaps:	151/717 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQIGGEE 92
            |..:.|.|||  :|.:|...:...|.|::.:...:...:.||||.:.||   .:...:|.|...:
Worm    19 PHNIIPLSYD--LLFKLPIHEFNGFTGSMVLHFNLSSLSDNITLDAVDL---HSFRNISLIRSAD 78

  Fly    93 TTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNT----VANE 153
            .||..:.|..:  ..:...|...|.|..|| |.|::           |.|.....|:    ....
Worm    79 LTEPTLKSIKI--LKEKVELKFEKSLFPGQ-YLLTI-----------GEYNGRIGNSSEALFERR 129

  Fly   154 TRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSN---MPVNETRPHESIPDYVW 215
            ...:..|..:|..||..|||.|.|..||.|.:::.:.......||   |.|:       :.:..|
Worm   130 NPLLYTTHLQPNHARRLFPCIDHPAVKALFRLSIVHPTDTVAQSNTIAMDVH-------VENRKW 187

  Fly   216 --TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNA--------IDQCDYAAELGPK 270
              |.|:.:..:..||||:|:...|:  ..|...|.|....|.|.        :..|..|:
Worm   188 QRTIFQATPLLPAYLVAFSVMPDSN--LQLSRQTSFGVTVRVNGESRGLVLRVLDCALAS----- 245

  Fly   271 VLKYYEELFG---IKFPLPKVDQIAVPDFSAGAMENWGLVTFAEST--------LLYSPEYSSQE 324
                :|.|.|   :..||.|:|.|.||::. |.|||||.:|.:|:.        |:|
Worm   246 ----FEILAGLIDVPLPLNKIDFILVPEYD-GGMENWGHITVSETLATSGDDAHLIY-------- 297

  Fly   325 AKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLT 389
                   ::|||:||.|.||..|:..|..:.|.|....::|...|:.:......||...::..:.
Worm   298 -------LIAHEIAHHWIGNRATIDSWNWICLQEDLTDWMALKAVKALLTDEIRLQRFQLAQYVE 355

  Fly   390 I-FRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTY 453
            | ..:|.|...|.:..|.::..::   .:...|.||..::..:...:||:...:.:||.:..::.
Worm   356 IQLVEDFLSPGHSLYMPSKINQEL---INRHCYLKGVVLLDTLESVVGEQFMYSVIKSLVGSHST 417

  Fly   454 KNAEQDNLWESLTQAAHKTGSLPKDYN--IKTIMDSWTLQTGYPVINVTRD-YTSRTAKLSQERY 515
            .|         ||........:..|.|  :..|.:.|....|||.|.|..: .:||..:||
Worm   418 YN---------LTTFTSYFDQIRVDRNATVGQIYEYWYTTGGYPSILVENNGPSSRLQQLS---- 469

  Fly   516 LLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQ 580
                      :..|  ||..|       :..|..:::    ..||:.....:.|     ::.|..
Worm   470 ----------RPLW--PLKMT-------STLAIPQFV----FSESIVFASENAP-----LLVNLN 506

  Fly   581 LSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQD-----YEIALQVIS 640
            .::..:||||:..|..:.:.: .|:......|.||||:.|..||....:.|     .|..:.::.
Worm   507 FTSFMRVNYDSLTWTAIFKYM-FEEPELFSAVGRAQLVSDFCYFYANDKVDNGTILKEAVVDMVY 570

  Fly   641 YLERERELLPW----------KSAFDN------LQFVSGILRQTPNFRFFKNFTRRLITPIYEHL 689
            ......||..|          :|.|..      |:|.|.....|..|........|.:....|.:
Worm   571 SKPEFFELCDWNLYWCHSRSDQSLFAQVVRSLALRFSSATFESTSAFGCKNGMAARSMNQFCERI 635

  Fly   690 NG 691
            .|
Worm   636 FG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	115/485 (24%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	30/139 (22%)
T12E12.6	NP_500831.2	GluZincin	25..402	CDD:387391	105/432 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020