Protein Alignment CG11951 and T12E12.6

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_500831.2
• Gene: T12E12.6 / 188454
• WormBaseID: WBGene00020465
• Length: 641
• Species: Caenorhabditis elegans
• Alignment Length: 717
• Identity: 164/717 - (22%)
• Similarity: 270/717 - (37%)
• Gaps: 151/717 - (21%)

  Fly    28 PTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQIGGEE 92
            |..:.|.|||  :|.:|...:...|.|::.:...:...:.||||.:.||   .:...:|.|...:
 Worm    19 PHNIIPLSYD--LLFKLPIHEFNGFTGSMVLHFNLSSLSDNITLDAVDL---HSFRNISLIRSAD 78

  Fly    93 TTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNT----VANE 153
            .||..:.|..:  ..:...|...|.|..|| |.|::           |.|.....|:    ....
 Worm    79 LTEPTLKSIKI--LKEKVELKFEKSLFPGQ-YLLTI-----------GEYNGRIGNSSEALFERR 129

  Fly   154 TRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSN---MPVNETRPHESIPDYVW 215
            ...:..|..:|..||..|||.|.|..||.|.:::.:.......||   |.|:       :.:..|
 Worm   130 NPLLYTTHLQPNHARRLFPCIDHPAVKALFRLSIVHPTDTVAQSNTIAMDVH-------VENRKW 187

  Fly   216 --TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNA--------IDQCDYAAELGPK 270
              |.|:.:..:..||||:|:...|:  ..|...|.|....|.|.        :..|..|:
 Worm   188 QRTIFQATPLLPAYLVAFSVMPDSN--LQLSRQTSFGVTVRVNGESRGLVLRVLDCALAS----- 245

  Fly   271 VLKYYEELFG---IKFPLPKVDQIAVPDFSAGAMENWGLVTFAEST--------LLYSPEYSSQE 324
                :|.|.|   :..||.|:|.|.||::. |.|||||.:|.:|:.        |:|
 Worm   246 ----FEILAGLIDVPLPLNKIDFILVPEYD-GGMENWGHITVSETLATSGDDAHLIY-------- 297

  Fly   325 AKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLT 389
                   ::|||:||.|.||..|:..|..:.|.|....::|...|:.:......||...::..:.
 Worm   298 -------LIAHEIAHHWIGNRATIDSWNWICLQEDLTDWMALKAVKALLTDEIRLQRFQLAQYVE 355

  Fly   390 I-FRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTY 453
            | ..:|.|...|.:..|.::..::   .:...|.||..::..:...:||:...:.:||.:..::.
 Worm   356 IQLVEDFLSPGHSLYMPSKINQEL---INRHCYLKGVVLLDTLESVVGEQFMYSVIKSLVGSHST 417

  Fly   454 KNAEQDNLWESLTQAAHKTGSLPKDYN--IKTIMDSWTLQTGYPVINVTRD-YTSRTAKLSQERY 515
            .|         ||........:..|.|  :..|.:.|....|||.|.|..: .:||..:||
 Worm   418 YN---------LTTFTSYFDQIRVDRNATVGQIYEYWYTTGGYPSILVENNGPSSRLQQLS---- 469

  Fly   516 LLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQ 580
                      :..|  ||..|       :..|..:::    ..||:.....:.|     ::.|..
 Worm   470 ----------RPLW--PLKMT-------STLAIPQFV----FSESIVFASENAP-----LLVNLN 506

  Fly   581 LSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQD-----YEIALQVIS 640
            .::..:||||:..|..:.:.: .|:......|.||||:.|..||....:.|     .|..:.::.
 Worm   507 FTSFMRVNYDSLTWTAIFKYM-FEEPELFSAVGRAQLVSDFCYFYANDKVDNGTILKEAVVDMVY 570

  Fly   641 YLERERELLPW----------KSAFDN------LQFVSGILRQTPNFRFFKNFTRRLITPIYEHL 689
            ......||..|          :|.|..      |:|.|.....|..|........|.:....|.:
 Worm   571 SKPEFFELCDWNLYWCHSRSDQSLFAQVVRSLALRFSSATFESTSAFGCKNGMAARSMNQFCERI 635

  Fly   690 NG 691
            .|
 Worm   636 FG 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	115/485 (24%)
		ERAP1_C	574..902	CDD:463368	30/139 (22%)
T12E12.6	NP_500831.2	GluZincin	25..402	CDD:472708	105/432 (24%)