DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	751	Identity:	207/751 - (27%)
Similarity:	331/751 - (44%)	Gaps:	133/751 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FRLPTALRPQSYDVRILTQL------ENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTI----- 78
            :|||..:.|..||:.|.|.|      .:.:...|.|.|.|.:::.:.|..:.|||..|.|
Worm    30 YRLPRHVSPSHYDIHIKTYLPGYGWKADENKITFEGNVNILLDIKETTDKLVLHSSSLNIISATF 94

  Fly    79 --DDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGY 141
              |:..:::|. ...:|....:|         ||:.||.|           :..||.:|....|.
Worm    95 QSDEQNVSISH-WNVQTESQFLT---------FYLNNTVK-----------VQSSAGIQINFQGK 138

  Fly   142 YRSSYVNTVA-NETRWIS------VTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNM 199
            .|:..:...| |.||...      .||||...||...||||||.:||::.::|.:....|.|||.
Worm   139 VRTDGLGLFATNSTREDGTVMTNFATQFETIFARNMIPCFDEPEFKATWNVSLEHPTGSTALSNG 203

  Fly   200 PVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYA 264
            ...|::.::   |:..|:::::|.||:|::|..:.|...|.:.|.||...|.:..|..||:.|:|
Worm   204 IEVESKVND---DWKTTTYKKTLKMSSYILALFIGDIQFKETILNNGVRIRVYTDPVNIDRVDHA 265

  Fly   265 AELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQET 329
            ..:...||:.:|..|||::|:.|:|.::|.:|..|||||||||.....:|:..|        .:.
Worm   266 LNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFGAMENWGLVIHNAYSLIGDP--------MDV 322

  Fly   330 ANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWR--TLQLESMSNLLTIFR 392
            ..||.||:||||||||||||:|..:|||||||:|:.|..:..:.|.::  |..|....|......
Worm   323 TEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYMTSYGLTFLDPDYQRDTFYLNCQFNPQINDG 387

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            ..||.....:|..:...:.:        |.||.|.:||:....|.|.|...:|.||||..|.|.:
Worm   388 GVSLNFGKNLSSVMNNAATV--------YMKGCSFVRMLENIFGTEYFNEAIKFYLEKNQYDNVD 444

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRD---YTSRTAKLSQERYLLNT 519
            .::|:|:...::....:..|.::|:.....||.|.|:|.|.|:.|   .|...:.|.:.:.:||.
Worm   445 DNDLYEAFRTSSETLDTNGKPFDIEKFARCWTHQNGFPTIQVSNDNGIATLTQSHLYEPQLMLNE 509

  Fly   520 DVSRAHKGC---WWVPLSYTNQEEKDFNNTAPKEWMECTETG-ESVPKTIHDLPGPDQWVIFNNQ 580
                    |   |.:|:.|....|.    .....|:....|. |.|         .|..||.|..
Worm   510 --------CDYKWDIPIWYQEPGEA----RVQMAWLNRNSTSLELV---------ADDSVIINAN 553

  Fly   581 LSAPYKVNYDAQNWKLLIE--TLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISY-- 641
            ....|:|.|..:.::.:.|  .:|...| |::.:.|.  :.||..::..|...:..|. :|:|
Worm   554 SIGYYEVLYSDKMYEKIAEQVAINVSRY-SVNSLRRT--LHDVFRYSRDGLTPFHNAF-IIAYVL 614

  Fly   642 LERERELLPWKSAF-----------------DNLQFVSGILRQTPNFRFFKN----------FTR 679
            :..|.|:|..:|..                 .:::.|.|::.|..||..|..          :.:
Worm   615 VFGENEILRHESVLYLVDAVYNTNNKSIVNSKDIETVKGLVNQIENFELFPKCVQSQTFSSCYQK 679

  Fly   680 RLITPIYEHLNGINDTVASEEQQDKTILKAIVADWA 715
            |:  |...:|..|.....|:...|      ::..||
Worm   680 RI--PQNINLRAIMQLKLSQNTMD------LIVAWA 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	147/476 (31%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	35/173 (20%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	127/389 (33%)
		M1_APN_2	39..482	CDD:189008	150/482 (31%)
		ERAP1_C	548..>622	CDD:288671	19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2868
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.970