DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and anp-1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	285/960 - (29%)
Similarity:	459/960 - (47%)	Gaps:	124/960 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLPTALRPQSYDVRILTQL------ENPDDFHFNGTVKIQIEVLQNTHNITLHSKDL-------- 76
            ||||::.|.||.:.:.|.|      .:.::..|.|.|.|::.:.::...::|:||||
Worm    85 RLPTSVSPISYQLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYTEEFIK 149

  Fly    77 -------------TIDDTEITLSQI--GGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYEL 126
                         |:||.:.|..:|  ..:||.|...::|                        |
Worm   150 KSSILVNGKSIAFTLDDKQSTHEKIFFNLDETVEPTTSAT------------------------L 190

  Fly   127 SLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHK 191
            .:.|.|.|:..::|.|:::|.|: ..|::..:|||.||..||...||||||.|||::.:|:.:..
Worm   191 KVAFGAPLRTDMSGLYQTTYTNS-KGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPN 254

  Fly   192 KYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPN 256
            |...:||  ..|.:..:..|.::.::|:.:..||:||:|..:::|.:..:|..:|..||.|:||.
Worm   255 KTVAVSN--GIEDKVEDGQPGFIISTFKPTPRMSSYLLAIFISEFEYNEATTKSGVRFRVWSRPE 317

  Fly   257 AIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYS 321
            ..:...||.|.|.|.|:|||:.:.|.|||||.|.:|:|||||||||||||:|:.||.|||.|...
Worm   318 EKNSTMYAVEAGVKCLEYYEKYYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIY 382

  Fly   322 SQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHP------QWRTLQ 380
            |...|:..|.::||||||||||||||:|||.||||||||||.|..|..::|..      :|.|
Worm   383 SGSQKRRVAVVIAHELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFT-- 445

  Fly   381 LESMSNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLK 445
               |..|.:....||:.|:||::..|:...::.:|||.::|.||.:|:.|:...:|||.|.||:.
Worm   446 ---MDALWSALAADSVASTHPLTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGIN 507

  Fly   446 SYLEKYTYKNAEQDNLWESLTQAAHKTGSLPK--DYNIKTIMDSWTLQTGYPVINVTRDYTSRTA 508
            .||.::.:.||:..||..:|.:....:...||  ..||...||.||.|.|||::|.:|...:...
Worm   508 HYLTRHQFDNADAGNLLTALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHII 572

  Fly   509 KLSQERYLLNTDVSRAHKGC-------WWVPLSY--TNQEEKDFNNTAPKEWMECTETGESVPKT 564
             :.|.|:.|........|..       |.||:.|  ....|.:.      :||:..|     |..
Worm   573 -VEQSRFKLLATGKEEEKYSNPVWGFKWDVPVWYQVVGSSELEM------KWMKRNE-----PLI 625

  Fly   565 IHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGE 629
            |..    |:.||.|.:.:..|:..|.:..||.:.|.| .|::.......|.:||||....|..|.
Worm   626 IKS----DKNVIINAESNGFYRAGYSSGLWKEISEML-KENHEQFSPQTRVRLIDDSFALARAGL 685

  Fly   630 QDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGIN- 693
            ..|.|.|.:|:||:.|:|.|||..|...::.:..:....|.    |:...:.:..:.|:.....
Worm   686 LSYSIPLNLITYLKNEKEYLPWSGAIAKIRELIDMYGSNPE----KDIVNKFMIALAENAPARRS 746

  Fly   694 -DTVASEEQQDKTILKAIVADW----ACSFEVSDCVTQALSFYRS---WRSEANP--DEVNPVPL 748
             |.|:.....:|...:...|..    :|.|..|.|....:..:..   .:.:|..  .|.:.:|.
Worm   747 IDFVSKNYLDEKKFYEVGAAQQIILNSCGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIPA 811

  Fly   749 GIRGVVYCTAIKHGCDEDWD--FLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGM- 810
            ..|...||.|:::|..:.::  |.|.:.::..|  ||..::.:|.||:::..|::.|   .|.|
Worm   812 PFRAESYCEAVRNGNSDTFEKVFHWYKTERNQV--EKLNLMTALTCSKDILTLKKLL---LDAMK 871

  Fly   811 ---GDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQR 872
               ...|.||..::|..|:.::........:|:|..:.:.|.........|.:|..:...:.|:.
Worm   872 PEGSSFRLQDCAALFAKISSNDATTDAMLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRG 936

  Fly   873 DYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKERNYERFTRAISK 922
            ..|:...|   .|...|..|..:.:..|:..:.|.|:|.|.:..|:.|.:
Worm   937 GLDQLRKF---RKKAPKASEFGLDKMEESAEVTVTWRETNLKFVTKIIEE 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	175/491 (36%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	77/344 (22%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	156/432 (36%)
		M1_APN_2	93..559	CDD:189008	178/497 (36%)
		ERAP1_C	632..964	CDD:288671	77/344 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H114373
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920