DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Y42A5A.1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_505820.1	Gene:	Y42A5A.1 / 179536	WormBaseID:	WBGene00012776	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	933	Identity:	259/933 - (27%)
Similarity:	415/933 - (44%)	Gaps:	166/933 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 STYDHFRLPTALRPQSYDVRILTQLENP---------DDFHFNGTVKIQIEVLQNTHNITLHSK- 74
            :|....::|....|..|:|.:  :|..|         |:|...|.|::.. .......|.|||.
Worm   146 NTNHRLQIPQIHIPLLYEVEL--KLFVPWRPTISFGSDNFSVKGHVRVHF-TSGGGSRILLHSDS 207

  Fly    75 -----DLTIDD---TEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFS 131
                 |..:.|   ..||:..:|.:.:              ....||...:::.|..|.|.:.|.
Worm   208 KQHIGDCVVRDELNRNITVKLVGRQYS--------------QILDLNLETDMIHGMNYTLDVAFK 258

  Fly   132 AKLQDQLA-GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTG 195
            :.:...|| |.:.:.|  |..||||::..||.:.:.||..|||.|.|..||.|...:.:....|.
Worm   259 SAINLNLAYGLFAAPY--TFENETRYVVATQLQISEARTVFPCIDVPDMKAQFDTVIIHPTGTTS 321

  Fly   196 LSNMPVNETRPHESIPDYVW--TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARP-NA 257
            ::||..|.|:     .|..|  |:|..:.||||||.|:|::|:.:..:....|...|.:..| ..
Worm   322 IANMMENSTK-----VDGEWTTTTFHRTPPMSTYLFAFSVSDYPYLETFSGRGVRSRVYCDPTKL 381

  Fly   258 IDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSS 322
            :|.......:|| ||.:||:.|||.:||.|:|.:.||..|..|||||||:|..::..||:....:
Worm   382 VDAQLITKSIGP-VLDFYEDYFGIPYPLEKLDVVIVPALSVTAMENWGLITIRQTNGLYTEGRFA 445

  Fly   323 QEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDI-HPQWRTLQLESMSN 386
            ...|.:...||||||||||||||||||||.||||||||||.::...|:.: :..||.....:.|.
Worm   446 ISQKHDVQEIVAHELAHQWFGNLVTMKWWNDLWLNEGFATLISVRAVDFLENTTWRYEDSSAESQ 510

  Fly   387 LLTIFRKDSLESSHPISRPIEMTSQISESFDE--------ISYQKGSSVIRMMHLFLGEEAFRTG 443
            .:.: |.|.::|..|:|      .:.:.:||.        |.|:|.:.:|||:...:.|:.||.|
Worm   511 CVAL-RADQIDSISPVS------GKKNSNFDSYMEIQGKAIIYKKSAIIIRMIERLVEEDIFRQG 568

  Fly   444 LKSYLEKYTYKNAEQDNLWESL------TQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRD 502
            ||.:|..:.||||:.::|:..|      :...|..|   :::::..:||:|..|..:|||:|.|.
Worm   569 LKRFLNTFLYKNADHEDLFNVLVYVHDSSAGGHLRG---QNFSLSDVMDTWIRQAHFPVIHVNRK 630

  Fly   503 YTSRTAKLSQERYLLNTDVSR--AHKGCWWVPLSY---TNQEEKDFNNTAPKEWMECTETGESVP 562
            ..| ...|.||:|   ..|.|  ..|..|.:|:.|   .:.:.|.|       |:..|:     |
Worm   631 EGS-LVTLRQEKY---EHVPRDEPEKQVWKIPIFYDDPVSGKHKVF-------WLTDTQ-----P 679

  Fly   563 KTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWT 627
            | :.|:.|  ..|:..:||:. .::.||.:.:..:...| .:|:..|...:|::||||.|..|..
Worm   680 K-VFDMGG--LLVVDPHQLTY-MRLRYDMEMYSDITMAL-MDDFTMIPTNSRSRLIDDTLAMAEN 739

  Fly   628 GEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGI 692
            |:..|::...:..|:.||....|:::....|.|....:.....:..:|.:...::...::..|..
Worm   740 GQLTYKVPFNLTMYMSREIAYRPFQTFSAYLDFFLPRMYIHEGWSIYKKYLELVVGIPFDKFNAE 804

  Fly   693 NDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPD-------EVNPVPLGI 750
            ...|:.:...|....:.||...||..|...||..|...:...|...:.:       |.|.:|..:
Worm   805 GLDVSFDHNTDLFHTRQIVVFRACGIEYEPCVRMAKQRFAELRVNCSGENQLLSGMECNKIPYYL 869

  Fly   751 RGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYL---ERNFDGM-- 810
            |..||..||..|..||:|||   |:|                    |:::.|:   :..|.|:
Worm   870 RPHVYSAAINDGTQEDFDFL---YKK--------------------WMIEHYMMEHDNIFTGLCT 911

  Fly   811 GDIRKQDSTSVFQAIAD-----------------SEVGFLL-----AKKYLMDNVDSISKFYHPQ 853
            .:||:....:..|.|.:                 |:..|:|     .|.||.:.||...|
Worm   912 TNIRENSDRAWRQVIKNGARENVMVRAQLCSKKLSKNNFILDLLYEDKVYLKEFVDKDRK----- 971

  Fly   854 SESMSELLPPLSEQIFTQRDYDE 876
                  .|..|.:.::.:.:|:|
Worm   972 ------SLFALQQLLYRKINYEE 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	158/491 (32%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	73/337 (22%)
Y42A5A.1	NP_505820.1	Peptidase_M1	159..549	CDD:279741	137/421 (33%)
		M1_APN_2	181..623	CDD:189008	155/474 (33%)
		ERAP1_C	688..998	CDD:288671	73/337 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020