DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and pam-1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	940	Identity:	270/940 - (28%)
Similarity:	453/940 - (48%)	Gaps:	107/940 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GLSFAGEGSTYDHF-RLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKD 75
            |::..|..|....| ||||...|..|:||:...|   :.|.|:|...|.:.:.:.|..:.:|::.
Worm    64 GMAACGNPSAAVKFERLPTFAEPTHYNVRLSPCL---NQFSFDGHATIDVTIKEATDVLKVHAQS 125

  Fly    76 LTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYI-LNTCK--ELLAGQFYELSLPFSAKLQDQ 137
            |.|....: ::|.|.        .|.::..::|..: :.|.|  ..:..|..:|...|..:|.|:
Worm   126 LLIQSVSL-ITQPGD--------ASKSLETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELNDK 181

  Fly   138 LAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPV- 201
            :.|:|||.|.:....| ::::.||||...||.||||||||.|||:|.:||......|.||||.|
Worm   182 MRGFYRSQYKDKNGTE-KFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVI 245

  Fly   202 NETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAE 266
            :||...:.....|  :|..|..||:||||:::.:..:..:...:|...|.:..|...:|..|:.:
Worm   246 SETPTADGKRKAV--TFATSPKMSSYLVAFAVGELEYISAQTKSGVEMRVYTVPGKKEQGQYSLD 308

  Fly   267 LGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETAN 331
            |..|.:.:|.|.|.||:||||.|.||:||||.||||||||||:.|..||..|..:|...|...|.
Worm   309 LSVKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVAL 373

  Fly   332 IVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSN-LLTIFRKDS 395
            :|||||||.||||||||||||||||.||||:::..:.|....|::: :.|..::: |.:....|:
Worm   374 VVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFK-IWLHFLNDELASGMGLDA 437

  Fly   396 LESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDN 460
            |.:||||...|:..:::.|.:|.|:|.|.:||.||:..:|.|..|:.||:.||:::.|.||...:
Worm   438 LRNSHPIEVEIDNPNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQD 502

  Fly   461 LWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVT--RDYTSRTAKLSQERYLLNTDVSR 523
            ||.:|::|:.:        |:..:|..||.|.|:||:.|:  :|..:|...:.|.|::  :|...
Worm   503 LWTALSEASGQ--------NVNELMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFI--SDGGE 557

  Fly   524 AHKGC-WWVPLSYT--------------NQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQ 573
            ..|.. |.||::..              .:::::|             |.|.|        .|.:
Worm   558 DPKNSQWQVPITVAVGSSPSDVKARFLLKEKQQEF-------------TIEGV--------APGE 601

  Fly   574 WVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQV 638
            ||..|:..:..|:|.|..:....::..:.|   ..:.|::|..||:|:.....||.......:||
Worm   602 WVKLNSGTTGFYRVEYSDEMLTAMLPDIAS---RRMPVLDRFGLINDLSALLNTGRVSIAQFVQV 663

  Fly   639 ISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLN---GINDTVASEE 700
            .:...:|.|.:.|.:..:.:..:....|:......  ...::|:..::|...   |..:....:.
Worm   664 AASSAKEDEYVVWGAIDEGMSKLLACAREMSEDTL--KSAKQLVVKMFEQTGAELGFAEQAGEDS 726

  Fly   701 QQDKTILKAIV---ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHG 762
            |  |.:|:::|   ...|......|..||..:.:....:..:||    :.|...|||    .::|
Worm   727 Q--KMMLRSLVQARLARAGHQPTIDKFTQMFNDFLEKGTPIHPD----IRLATFGVV----ARYG 781

  Fly   763 CDEDWDFLW-----TRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVF 822
            ..|.:|.|.     |.:|:    .|:|.:: ::..:.|..:|.:..|..|: ...:|.||...:|
Worm   782 GKEGFDKLMNLRETTTFQE----IERQTMV-AMSQTPEESLLAQLFEYGFE-KNKVRPQDQLYLF 840

  Fly   823 QAIADSEVGFLLAKKYLMDNV-DSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMAS--- 883
            .....:.:|...|.||..::: :.:.|:....|......|....|....::...||.:|..:
Worm   841 LGTGATHMGQQYAWKYFCEHIKEFLDKYGGANSSLFQRCLKFAGESFGNEKRAVEFQDFFCNCNV 905

  Fly   884 -SKDQLKDIEQTISQSLETMLINVQWKERN 912
             |....:.:.:.|.|::|.:.:|.:..|.|
Worm   906 LSDTDRQTLARPIGQTVEAIRLNARLLESN 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	170/459 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	68/343 (20%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	173/465 (37%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	68/345 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020