DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Y67D8C.9

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001122826.1	Gene:	Y67D8C.9 / 177088	WormBaseID:	WBGene00022073	Length:	1144	Species:	Caenorhabditis elegans

Alignment Length:	964	Identity:	243/964 - (25%)
Similarity:	401/964 - (41%)	Gaps:	191/964 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LPTALRPQSYDVRI-LTQLENPDDFH--FNGTVKIQIEVLQNT-------H---NITLHSKDLTI 78
            ||..:.|..||::: .:|.    |.|  ....:.|.:|...|:       |   ||.:....|..
Worm   182 LPLYILPYHYDLQLDFSQF----DTHLFIRANISIHLESYGNSTEDEIQFHLGPNIKMERMRLRK 242

  Fly    79 DDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYR 143
            |..:........||:.:....|              .::.|....|.|.:.::..:.|:.....|
Worm   243 DGKKFYAKTFKREESKKLGRIS--------------LRDPLQKGKYILEMTYNMTICDEDVDGVR 293

  Fly   144 SSYVNTVANETRWIS-VTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPH 207
            .|..|...:..:..| .|:|||..||..|||:||||.||:|.|::.::||||.|||||..|:..|
Worm   294 CSLDNQTNSSLKATSFTTKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTVLSNMPPVESHDH 358

  Fly   208 ESIPD-YVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKV 271
            :|..| :..|.|:.:.||||||:|:::.:|....|....|.....|..|..:....:..|..|.:
Worm   359 KSWEDQFKTTVFQTTPPMSTYLLAFAIGEFVKLESRTERGIPVTVWTYPEDVMSMKFTLEYAPVI 423

  Fly   272 LKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETAN----- 331
            ....|:...|.:||||||.||..:|..|.|||||||.|..:::.|:|..:  :...||.:
Worm   424 FDRLEDALEIPYPLPKVDLIAARNFHVGGMENWGLVVFEFASIAYTPPIT--DHVNETVDRMYNE 486

  Fly   332 -----IVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIF 391
                 ::|||.|||||||||||:.|::|:|||||||:.....:....|.  |.|.|...:|.::.
Worm   487 FRIGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPV--TAQFEYYDSLASLI 549

  Fly   392 RKDSLESSHPIS--RPIEMTSQISESFDEIS-YQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTY 453
            ...| |..|.:|  |.:...||:..||...: |.||..:|||:...:.:..|:..::.||.|..|
Worm   550 LAQS-EEDHRLSLVRELATESQVESSFHPTNLYTKGCVLIRMLRDLVSDFDFKAAVRRYLRKNAY 613

  Fly   454 KNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN 518
            ::..:|:|:.||...|.......|   :..:::.|.:..|.|.|.:.|:|.:....:||.:.:.:
Worm   614 RSVSRDDLFASLPAYADHGAEQEK---LSHVLEGWFVNEGIPEITLIRNYDNEMMTISQRKTVHH 675

  Fly   519 --------------------------------------------------------------TDV 521
                                                                          :.:
Worm   676 EYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKKDRRRKHRPIRRKTSTPPSISPI 740

  Fly   522 SR-----------AHKGCWWVPLSYTNQEEKDFNNTAPKE-WME--CTETGESVPKTIHDLPGPD 572
            ||           |.:..|.:|::|.....|.......:| |::  ....|::.       ..|:
Worm   741 SRRDELRKPRRVGASQDLWTIPITYMFGSLKTSEGQVIREFWLKNRTVSFGDAE-------ISPN 798

  Fly   573 QWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQ 637
            |.|:.|.:...||:||||..|||||..||: :::..|:..:|.|||.|..||. :...:..:.|.
Worm   799 QAVLVNPEWKYPYRVNYDLLNWKLLARTLH-QNHLEINEKSRMQLILDAEYFL-SNSVNPHLYLY 861

  Fly   638 VISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQ 702
            ::.||..|.::.......|.:.....:.:.|...:....:...:|:.: :||  :|::....|..
Worm   862 LLGYLAHETKMEVMLFGIDAVYKFIDVYKATQLNKAILVYFEPVISQM-DHL--LNESQVDAETA 923

  Fly   703 DKTILK----AIVADWACSFEVSDC----VTQALSFYRS---WRSEAN--------------PDE 742
            ...:::    |.:....|:..:|.|    .||..|  ||   |..:.:              |||
Worm   924 SLWLVRPERLAKLYQMRCAAGLSSCKNDYYTQRWS--RSPDEWTEDVHKQVTAVCHQLFTNTPDE 986

  Fly   743 VNPVP------LGIRGVVYCTAIK-HGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVL- 799
            |..|.      |...|..:...:: ..|..|...| .|..:|.|:|:..::..|  ..|..:.|
Worm   987 VKTVQDLLDSRLQSSGAKWALTVQLAACSHDQKLL-RRTARAIVSTKNAVVYAS--ALQSDFSLH 1048

  Fly   800 -----QRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISK 848
                 ::||......|....|   |::|   :.:....|.|.:.|:.:|.:|.:
Worm  1049 YNPTFRKYLWAEIAKMSTFEK---TALF---STNSTDILPASRILLHSVKTIDE 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	149/482 (31%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	72/313 (23%)
Y67D8C.9	NP_001122826.1	Peptidase_M1	182..584	CDD:279741	135/424 (32%)
Y67D8C.9	NP_001122826.1	M1_APN_2	190..652	CDD:189008	150/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020