Protein Alignment CG11951 and T16G12.1

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_499230.2
• Gene: T16G12.1 / 176416
• WormBaseID: WBGene00011803
• Length: 1890
• Species: Caenorhabditis elegans
• Alignment Length: 949
• Identity: 245/949 - (25%)
• Similarity: 400/949 - (42%)
• Gaps: 164/949 - (17%)

  Fly    26 RLPTALRPQSYDVRILTQLENP-------DDFHFNGTVKIQIEVL-------QNTHNITLHS-KD 75
            |||..|....|.:.......:|       .:|.|:|...||:|.|       .|.:|..:.| |.
 Worm    80 RLPPNLYAIDYSLWFQPYFPSPGVQYAPEKNFTFDGRASIQVEALVASDRFILNAYNFKIQSYKV 144

  Fly    76 LTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQL-A 139
            :.||.|.:.::.|..::||:.....|..|            .::|||.|.:...::..:.... .
 Worm   145 VDIDGTVVPINSISQDDTTQQLSLITNAN------------GVVAGQIYNIEFVYTGIINPYTDG 197

  Fly   140 GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNET 204
            |.|.:|| |.....|.::..|..||.:||..||..|||.|||.|.||:.|......||||  .||
 Worm   198 GVYYTSY-NDPQGNTHYMIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSNM--MET 259

  Fly   205 RPHESIPDYVWT--SFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAEL 267
            .|.:.  |.:|:  :|.::..||:||:|:::..:.:......:.||.|.|..|.......:||:.
 Worm   260 EPTKI--DNIWSTITFPQTPKMSSYLIAFAVGPYVNSQYVNKHNTLTRAWGWPGTEQYLQFAAQN 322

  Fly   268 GPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANI 332
            ..:.|....|..||||||.|.||:.:|:|.|||||||||:.:....:.|:|...:....:..|.:
 Worm   323 AGECLYQLGEYTGIKFPLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKV 387

  Fly   333 VAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTL--QLESMSNLLTIFRKDS 395
            :.|||||||||:|||..||.||:||||||.|..:...:.::||..|.  .|:.:..|......|.
 Worm   388 MCHELAHQWFGDLVTTAWWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADV 452

  Fly   396 LESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDN 460
            ...:||:..|      ...:||:|:|.||:|::||:...||.:.|:.|:::||:|..|.||...:
 Worm   453 RYDAHPLVYP------DGPAFDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFD 511

  Fly   461 LWESLTQAAHKTG-----SLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTD 520
            |:.:||..|....     .||  .|:...|..:..||.:|:|....:.....:..|||.:|..:|
 Worm   512 LFSTLTDTAKSNNILDWCGLP--LNVTDFMQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISD 574

  Fly   521 VSRA-HKGCWWVPLSYTNQEEKDFNNTAP-KEWME----CTETGESVPKTIHDLPGPD----QWV 575
            ::.. ....|.:||:..|....|     | |:|:.    |....|::.:  ..:..|:    ||.
 Worm   575 LTATPWNYTWSIPLTSANLRHAD-----PYKQWLPRQQGCANMNENIQE--ERIKEPNKRAVQWE 632

  Fly   576 IFNNQLSAPY-KVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYF--------------- 624
            : .:..||.| ::.||...:..:::.:..:|.:.  .:....|.|:..|.
 Worm   633 L-TSITSATYGRIIYDDIGFDRILKLIKQDDIND--NLKLTLLADEYNYMLREKKANRPFGYNRF 694

  Fly   625 -----------AWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFT 678
                       ::|....|.:..|....||:..:|  ::...| .:||..:.:     .||:|..
 Worm   695 LDLAKVIFNTQSFTNYPSYGVFAQAQPVLEQIAQL--YRDGID-AEFVPRLYK-----LFFQNSY 751

  Fly   679 RRLITPIYEHLNGINDTVASEEQQDKTI-----LKAIVADWACSFEVSDCVTQALSFYRSWRSEA 738
            .:|                  :.||.:|     ...:...:|..:::.|...:.|:.:.:.:|..
 Worm   752 NQL------------------KWQDTSIWDTDTFSEVFLPFAVRYDIGDVQNRTLNMFANVKSAC 798

  Fly   739 -----NPDEVNPVPLGIRGVVYCTAIKHG-CDEDWDFLWTRYQKANVAT------EKQIILDSLG 791
                 .....||....:|..:||.|.|:. ...|:.|.........|.|      |...:|:.:.
 Worm   799 INSLNGTAWCNPYSTNLRKAIYCGAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMS 863

  Fly   792 CSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFY--HPQS 854
            |:|....| :.|.|.|          :||...  ..:..|||   ||.....|.:..::  :||.
 Worm   864 CTQSPATL-KVLIRLF----------TTSTLN--PSTIFGFL---KYNPAASDVLYNYFMANPQL 912

  Fly   855 ESMSELLPPLSEQIFTQRDY------DEFMNFMASSKDQ 887
            .:.:.|...|....:....|      ...||.:..:.||
 Worm   913 VNSTMLDAYLDAMTYNWNSYFREGQLSTLMNTLTLTNDQ 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	154/479 (32%)
		ERAP1_C	574..902	CDD:463368	66/366 (18%)
T16G12.1	NP_499230.2	M1_APN-Q_like	90..544	CDD:341064	154/478 (32%)
		ERAP1_C	639..931	CDD:463368	59/335 (18%)
		M1_APN-Q_like	1005..1471	CDD:341064
		ERAP1_C	1542..1839	CDD:463368