Protein Alignment CG11951 and Lta4h

DIOPT Version :9

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 542
• Identity: 121/542 - (22%)
• Similarity: 211/542 - (38%)
• Gaps: 117/542 - (21%)

  Fly    54 GTVKIQIEVL-QNTHNITLHSKDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKE 117
            ||..:.::.. :|..::||.:|||||:..     .|.|:|..               |.|.. .:
Mouse    37 GTAALTVQSQEENLRSLTLDTKDLTIEKV-----VINGQEVK---------------YTLGE-SQ 80

  Fly   118 LLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANET-------RWIS------------VTQFE 163
            ...|...|:|||.:.....::        |..::.||       :|::            .:|.:
Mouse    81 GYKGSPMEISLPIALSKNQEI--------VIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQ 137

  Fly   164 PAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYL 228
            ....|...||.|.|..|.::...:...|:...|.:...:...|....|......|.:.:|:..||
Mouse   138 AIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYL 202

  Fly   229 VAYSLNDFSHK---PSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQ 290
            :|..:.....:   |.||       .|:....:::..........:||..|:|.| .:...:.|.
Mouse   203 IALVVGALESRQIGPRTL-------VWSEKEQVEKSANEFSETESMLKIAEDLGG-PYVWGQYDL 259

  Fly   291 IAV-PDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDL 354
            :.: |.|..|.||| ..:||...|||        ...:..:|::|||::|.|.|||||.|.|...
Mouse   260 LVLPPSFPYGGMEN-PCLTFVTPTLL--------AGDKSLSNVIAHEISHSWTGNLVTNKTWDHF 315

  Fly   355 WLNEGFATYV-ASLC-------VEDIHP--QWRTLQLESMSNLLTIFRKDSLESSHPISRPIEMT 409
            |||||...|: ..:|       ....|.  .|..||     |.:..|.:     |||.::.:...
Mouse   316 WLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQ-----NTIKTFGE-----SHPFTKLVVDL 370

  Fly   410 SQISE--SFDEISYQKGSSVIRMMHLFL-GEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHK 471
            ..:..  ::..|.|:||.:::..:...| |.|.|...||:|::|::|::...|: |:|...:..|
Mouse   371 KDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDD-WKSFLYSHFK 434

  Fly   472 TGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPL--- 533
            .   ..|...:...::|....|.|.:....|.|           |.|..::.:.:   ||..
Mouse   435 D---KVDLLNQVDWNTWLYAPGLPPVKPNYDVT-----------LTNACIALSQR---WVTAKEE 482

  Fly   534 ---SYTNQEEKDFNNTAPKEWM 552
               |::..:.||.::....|::
Mouse   483 DLSSFSIADLKDLSSHQLNEFL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	109/472 (23%)
		ERAP1_C	574..902	CDD:338125
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	121/542 (22%)
		M1_LTA4H	6..450	CDD:189006	109/472 (23%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	6/40 (15%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910