DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Rnpepl1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_852070.3	Gene:	Rnpepl1 / 108657	MGIID:	1914170	Length:	720	Species:	Mus musculus

Alignment Length:	689	Identity:	152/689 - (22%)
Similarity:	249/689 - (36%)	Gaps:	181/689 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALGLSFAGEGSTY--DHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQ-------- 64
            ||.::.|.....:  .|.:|...|||::.::.              |.:.:::..|:
Mouse    27 ALDVASASSAQLFRLRHLQLGLELRPEARELA--------------GCLVLELCALRPAPRALVL 77

  Fly    65 NTH-NITLHS----KDLTIDDTEIT--------------LSQIGGEETTENCITSTAVNPTHDFY 110
            :.| .:.|||    :...:.::..|              .:...|.|:. :|..:..::|..|:
Mouse    78 DAHPALRLHSVSFRRASAVSESPCTFAFPAPGSGPPLPGFADAPGAESA-SCPLAFRLDPFTDY- 140

  Fly   111 ILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANETRWIS------------VTQFE 163
                      |....::||...:.........|  |.:|.|....|:.            .||..
Mouse   141 ----------GSSLTVTLPPEVQAHQPFQVILR--YTSTDAPAIWWLDPELTYGNAKPFVFTQGH 193

  Fly   164 PAAARLAFPCFDEPGYKASFAIT----LGYHKKYTGLSNMPVNETRPHESIPDYVWTSFEESLPM 224
            ....|..|||||.|..|.:::..    ||.....:...::.|.|...:.         |....|:
Mouse   194 SVCNRSFFPCFDTPAVKCTYSAVVKAPLGVQVLMSATQSVYVEEEGLYH---------FHMEHPV 249

  Fly   225 STYLVAYSLNDFSHKPSTLPNGTLFRTWARP-----------NAIDQCDYAAE--LGPKVLKYYE 276
            ..||||....|.  ||:.:  |...|.||.|           .|::|...|||  .||.:...|:
Mouse   250 PAYLVALVAGDL--KPADI--GPRSRVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYD 310

  Fly   277 ELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQW 341
            .:|     ||       |.|...|||| ..:||..|::|.|.|:...:        |.||:||.|
Mouse   311 IVF-----LP-------PSFPIVAMEN-PCLTFIISSILESDEFLVID--------VIHEVAHSW 354

  Fly   342 FGNLVTMKWWTDLWLNEGFATY-----------VASLCVED------IHPQWRTLQLESMSNLLT 389
            |||.||...|.::||:||.|||           .|..|:|.      :|.|.|.|..:|..:.|.
Mouse   355 FGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMRLLGEDSPVSKLQ 419

  Fly   390 IFRKDSLESSHPISRPIEMTSQISESFDEISYQKG-SSVIRMMHLFLGEEAFRTGLKSYLEKYTY 453
            :..:..:..||.::.              .:|:|| ..|..:..|..|.:.|...|::|:|||.:
Mouse   420 VKLEPGVNPSHLMNL--------------FTYEKGYCFVYYLSQLCGGPQRFDDFLRAYVEKYKF 470

  Fly   454 KNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLN 518
            .:....:|.:|......:......|.......:.|...||.|:..         ..|||     .
Mouse   471 TSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAE---------PDLSQ-----G 521

  Fly   519 TDVSRAHKGCW--WV--PLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNN 579
            :.::|..:..:  |.  ||   .|.....:.....:| ...:|...:.:.:...|.|.:.|:
Mouse   522 SSLTRPVEALFQLWTAEPL---EQAAASASAIDISKW-RTFQTALFLDRLLDGSPLPQEVVM--- 579

  Fly   580 QLSAPYKVNYDAQNWKLLIETL----NSEDYHSIHVVNR 614
            .||..|....|:.|.::.|..|    .::.|..:|.|.|
Mouse   580 SLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLHRVRR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	117/528 (22%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	12/45 (27%)
Rnpepl1	NP_852070.3	M1_LTA4H	29..507	CDD:189006	123/553 (22%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	321..325		2/3 (67%)
		Leuk-A4-hydro_C	524..668	CDD:312599	21/102 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910