DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and rnpepl1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001335117.1	Gene:	rnpepl1 / 100535895	ZFINID:	ZDB-GENE-030131-5522	Length:	692	Species:	Danio rerio

Alignment Length:	745	Identity:	171/745 - (22%)
Similarity:	273/745 - (36%)	Gaps:	192/745 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CVFLILAALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVK---------- 57
            |...:|...|.|..| |.:..|.||.......::....|.....  |.|.|..||
Zfish    11 CCRKVLTVPGKSCEG-GRSLAHCRLVDIASASNFHCFKLRHFHL--DLHLNFAVKRITGWQVLEL 72

  Fly    58 ------IQIEVLQNTHNITLHSKDLTIDDTEITLSQIGGEETTENCITST-AVNPTHDFYILNTC 115
                  :|..:|....::.:||.|..:.         |.....:..::.| .|.|..|:
Zfish    73 TPVQPGVQSLILDTHPSLLIHSVDCKVP---------GASGAPDVFLSLTYRVEPFTDY------ 122

  Fly   116 KELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNT------------VANETRWISVTQFEPAAAR 168
                 |....::|| :|.::...|......|..|            ...:||.:..||......|
Zfish   123 -----GSSLNITLP-AAVIRPHRAFRVTVRYTTTDGPAIWWLDAELTCGQTRPLVFTQGHSVCNR 181

  Fly   169 LAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSL 233
            ..|||||.|..|::::.|:...:..|.|    ::.:|...|..|.|: .|....|:..||||...
Zfish   182 SFFPCFDTPAVKSTYSATVRVPEGVTVL----MSASRSAYSKQDRVF-QFSMEYPVPAYLVALVA 241

  Fly   234 NDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKV---LKYYEELFGIKFPLPKVDQIAV-P 294
            .|..|...    |...|.||.| .|..| ..::||..|   |...|.||| .:...:.|.:.: |
Zfish   242 GDLQHADI----GPRSRVWAEP-CILTC-AVSKLGGSVERWLNVAEGLFG-PYVWGRYDLVFLPP 299

  Fly   295 DFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEG 359
            .|...|||| ..:||..|::|.|.|:...:        |.||:||.||||.||...|.::||:||
Zfish   300 SFPIVAMEN-PCLTFIISSILESQEFLLID--------VIHEIAHGWFGNAVTNATWEEMWLSEG 355

  Fly   360 FATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLE-------SSHPISR---PIEMTSQISE 414
            .|||.......:.:.       |:.:.|.|:||.|:|.       .::|:|:   ..|.....|.
Zfish   356 LATYAQRRITTEAYG-------EAFTCLETVFRLDALHRQMRLLGDNNPVSKLQAKFEPGVNPSS 413

  Fly   415 SFDEISYQKGSSVIRMMHLFLGE-EAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKD 478
            ..:..:|:||...:..:....|: :.|.:.|::|:||:.:.:....:|.:..      .|..|:
Zfish   414 LMNLFTYEKGFCFVSYLSQLCGDIKRFDSFLRAYIEKFRFSSVIAQDLLDFF------LGFFPE- 471

  Fly   479 YNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDF 543
                       |:.|         ..::...|..||:|         .|| ..||.     |.|.
Zfish   472 -----------LKEG---------CVAQREGLEFERWL---------NGC-GPPLC-----EPDL 501

  Fly   544 NN----TAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSE 604
            :.    |.|.:.: |...|..         .||..||          ..:|..:|......|..:
Zfish   502 SAGRTLTGPVQHL-CDLWGND---------APDTQVI----------STFDLSSWSTFQTVLFLD 546

  Fly   605 DYHSIHVVNRAQLIDDVL------YFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSG 663
                 .:::|:.|..:|:      |.|...:.:.|:.::.:..:.|       .|.:.:|
Zfish   547 -----RLLDRSPLSQEVMSLLSSCYAALLDDMNAEVQIRWLQIVVR-------NSFYPDL----- 594

  Fly   664 ILRQTPNFRFF--KNFTRRLITPIYEHLNG 691
                 |..|.|  |:.:|....|:||.|.|
Zfish   595 -----PRVRSFLHKHTSRMYTVPLYEDLCG 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	120/498 (24%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	24/126 (19%)
rnpepl1	NP_001335117.1	M1_LTA4H	36..490	CDD:189006	126/540 (23%)
rnpepl1	NP_001335117.1	Leuk-A4-hydro_C	507..649	CDD:312599	30/155 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910