Protein Alignment CG11951 and erap1

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_002933475.2
• Gene: erap1 / 100496768
• XenbaseID: XB-GENE-983344
• Length: 932
• Species: Xenopus tropicalis
• Alignment Length: 958
• Identity: 301/958 - (31%)
• Similarity: 491/958 - (51%)
• Gaps: 102/958 - (10%)

  Fly     1 MKCV-FLILAALGLSFA---GEGSTYDHFRLPTALRPQSYDVRI---LTQLENPDDFHFNGTVKI 58
            :.|: |.|..||..|.|   .|...:.:.||||...|..||:.|   ||.|.      |:|..|:
 Frog    23 LMCISFSIQPALAASKALDNAEMFPWKNLRLPTFAAPLHYDLLIHPNLTTLT------FSGLTKV 81

  Fly    59 QIEVLQNTHNITLHSKDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQF 123
            .:.|.|.|..:.||||.|.|..|.|. .::|.:...::.:...  :|.::...|.....|:.|:.
 Frog    82 TVTVTQKTSFLVLHSKHLEITKTTIK-RKLGKDPVLQDLLLRE--HPVNEQIALLAADPLIPGEN 143

  Fly   124 YELSLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLG 188
            |.:.:.::|.|.....|:|:|:| .|...|.|.::.|||||.|||.||||||||.:||||:|.:.
 Frog   144 YTIYIEYNANLSKNFRGFYKSTY-KTKDGEVRVLASTQFEPTAARTAFPCFDEPAFKASFSIQIR 207

  Fly   189 YHKKYTGLSNMPVNET--------RPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPN 245
            ...|:..:|||||.:|        ..|          |..|:.|||||||:.::||........:
 Frog   208 REPKHHAVSNMPVVKTVNIGGGLLEDH----------FAASVKMSTYLVAFIVSDFKSISQVTNH 262

  Fly   246 GTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFA 310
            |.....:|.|..|||.:||.:...|:|.:||:.|.|.:||||.|..|:|||.:||||||||.|:.
 Frog   263 GVRISVYATPEKIDQAEYALKAAVKLLDFYEDYFNISYPLPKQDLAAIPDFQSGAMENWGLTTYR 327

  Fly   311 ESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQ 375
            ||.||:.|:.|:...|.....|:|||||||||||||||:||.|||||||||.::..:.|...:|:
 Frog   328 ESALLHDPKTSTASHKLWVTMIIAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEYVSVRVTYPE 392

  Fly   376 WRTLQLES--MSNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEE 438
               ||:|.  :.........|||.|||.:|.|:|...:|.|.|||:||.||:.::.|:..::|.|
 Frog   393 ---LQVEDYFLDKCFRAMDVDSLNSSHAVSTPVENPEEIQEMFDEVSYDKGACILNMLMDYMGAE 454

  Fly   439 AFRTGLKSYLEKYTYKNAEQDNLWESLT-----------------QAAH-KTGSLPKDYNIKTIM 485
            :|..|:..||.:|:|:||..::||.|:|                 |.:| ..|.:   .::|::|
 Frog   455 SFEAGIVDYLRRYSYRNARNEDLWNSMTDVCPSDETNSGYCTKTRQTSHWSEGEI---IDVKSMM 516

  Fly   486 DSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKE 550
            ::||||.|:|::.||  ...:...|.||.||..:..:.|....|.:||:|...:    :||. :.
 Frog   517 NTWTLQKGFPLVTVT--VKGKYVYLHQEHYLKGSTDTEASGLLWHIPLTYITSK----SNTV-QR 574

  Fly   551 WMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRA 615
            ::..::|...|      |....:|:.||..::..|.|:|:.:.|..||:.| .|::.:|...:||
 Frog   575 FLLMSKTDVLV------LAEEVEWIKFNVGMNGYYIVHYEGEGWDALIKLL-QENHTAISSNDRA 632

  Fly   616 QLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILR-------QTPNFRF 673
            .||:........|....:.||.:..||:.|.:::|.....|.|..:..::.       ::...::
 Frog   633 NLINSAFQLVSIGRLPIDKALSLSLYLKNEDKIMPVFQGMDELIPIYKLMEKRDMQEVESQMKKY 697

  Fly   674 FKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEA 738
            ..|..|:||..         .:...|....:.:|::.:..:||..:...||.:|..:::.|: |:
 Frog   698 ILNLLRKLIDA---------QSWTDEGSVSERMLRSSLLLFACVRQYQPCVQRAEQYFKRWQ-ES 752

  Fly   739 NPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYL 803
            |  ....:|..:...||  |:.....|.||||:.:|:.....:||..|..:|..:.....||..:
 Frog   753 N--GTISLPRDVASAVY--AVGAQTPEGWDFLFEKYKTTLSGSEKNQIELALAITSLKHKLQWLM 813

  Fly   804 ERNFDGM-GD-IRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSE 866
            |   :|| || :|.||...:...::.:.||:.|:.::|.:|..::.:.:...|.::.:::..:::
 Frog   814 E---EGMKGDHVRTQDLPHIVLYVSRNPVGYPLSWEFLKNNWGNLVQKFELGSRTVGDMVVGITK 875

  Fly   867 QIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKERNYE 914
            |..|:...:|...|..|.|:....: :.:.|:.||:..|::|.::|.:
 Frog   876 QYSTKEWLEEVTGFFDSLKEMGSQL-RCVQQARETIEENIRWMDKNLD 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	185/485 (38%)
		ERAP1_C	574..902	CDD:463368	77/336 (23%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	185/486 (38%)
		ERAP1_C	592..911	CDD:463368	78/337 (23%)