DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and enpep

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	286/925 - (30%)
Similarity:	468/925 - (50%)	Gaps:	95/925 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLS 86
            :..|||||.:.|..|:|.:...:|...   :||||.|.:.:.:.:.::.||.::..|.. ::||:
Frog    95 WKEFRLPTYINPVHYNVELHPVMEQDT---YNGTVSIWLRLSKTSKHLWLHLRETKIIG-QLTLT 155

  Fly    87 QIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQF------------YELSLPFSAKLQDQLA 139
            :...:...:.|..          ||.|....|.|.|.            |.|:|.|:.:|...|.
Frog   156 RGSQQIPIQQCFQ----------YIPNEYLVLEAQQVLDPNSPTDENDTYCLTLQFAGRLDGSLV 210

  Fly   140 GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNET 204
            |:||::|...  ..|:.|:....||..||.:|||||||..||::.|::.:.::|..:|||||.|:
Frog   211 GFYRTTYQEN--GVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAISNMPVQES 273

  Fly   205 RPHESIPDYV-----W--TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCD 262
                     |     |  |.||:|:|||||||.::::.|.:.......|...|.:.:|......:
Frog   274 ---------VALGNGWKRTLFEKSVPMSTYLVCFAVHQFKYVERLSKRGVPLRIYVQPLQNATAE 329

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            |||.....|..::||.|.:.:.|||:||||:|||..||||||||:|:.|:.|||.|..|:...||
Frog   330 YAANTTKIVFDFFEEYFNMPYSLPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNESATVNKQ 394

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ..|.::||||.||||||:|||.||.|||||||||::.....|:...|.|..|....:.:||.:.|
Frog   395 RVAAVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDDLLPVMR 459

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            .|:|.|||||...:...::|:..||.|||.||:|::||:..::..|.|:.|.:.||:.|.:|||:
Frog   460 DDALLSSHPIIVTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDYVFKNAK 524

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVS 522
            .|:.|.||.:|:.|.        :|.:||:||.|.||||:||.   :..|.|  |.|:||:.:.:
Frog   525 TDDFWNSLAKASGKP--------VKEVMDTWTRQMGYPVLNVE---SLNTVK--QTRFLLDPNAN 576

  Fly   523 RAH-----KGCWWVPLS-YTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLP---GPDQWVIFN 578
            ...     ...|.:|:: |......|:|....|          |:|..:...|   ..|.::..|
Frog   577 ALEPPSEFNYMWNIPVTFYATNNSVDYNLLYNK----------SIPAGLSLTPFNDATDGFLKIN 631

  Fly   579 NQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLE 643
            .:....::|||:...|..|...|.: ::.:....:||.||||....|...:.||.|:|.:..|||
Frog   632 TRHLGFFRVNYELSTWNQLSALLEA-NHETFTDADRAGLIDDAFALARAEKLDYNISLDITKYLE 695

  Fly   644 RERELLPWKSAFDNLQFVSGILRQTPN-FRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTIL 707
            :|...|.|..|..:|.::|.:|..... :..|:.:.|:.:.||.:. :|..||.:..::    :|
Frog   696 KETNYLTWTRAISSLAYLSDMLEDDNTIYPKFQEYLRKQVKPITQK-HGWEDTGSDIDK----LL 755

  Fly   708 KAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKH-GCDEDWDFLW 771
            :|.|...:|.....|.:.:|...:|.|....:      :|:.:|.:||...::. |..|.|::::
Frog   756 RASVLALSCKMGDPDALNEASRLFRDWIGGKS------IPVNLRQLVYRYGMQQSGNQESWNYMF 814

  Fly   772 TRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLLA 835
            .:|...::|.||:.:|..|..:..:.::.|||:..:: ...|:.||:.:|...|: .|:.|..:|
Frog   815 QQYLTTSLAQEKEKLLQGLASANNIELIDRYLKLIYN-TSLIKSQDALNVIYYISVYSQYGKQMA 878

  Fly   836 KKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQ-LKDIEQTISQSL 899
            ..::..|.|.:...|:....::..::..:|....|.....:..||.....:. ..:|.:  .|:|
Frog   879 WDWVRINWDYLVDRYNINDRNLGRIVTRISGTFNTATQLWQMENFFEKYPNAGAGEIPR--KQAL 941

  Fly   900 ETMLINVQWKERNYE 914
            ||:..|::|...|.|
Frog   942 ETVRNNIEWVAANKE 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	173/473 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	78/331 (24%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	173/474 (36%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	79/333 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920