DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and anpep

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	308/941 - (32%)
Similarity:	493/941 - (52%)	Gaps:	75/941 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AGEGSTYDHFRLPTALRPQSYDVRILTQL-ENPDDFH-FNGTVKIQIEVLQNTHNITLHSKDLT- 77
            |.....::.:|||..|.|..|||.:...| :|.|..: |.|...........|..|.:||..|.
Frog    74 AQSNDPWNKYRLPKTLSPVHYDVELQPFLVKNADGLYVFRGKSTAFFICNDATDLIIIHSNKLNH 138

  Fly    78 --IDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAG 140
              .:..:..|.    :..|:..:.||.......|.::.....|:.|:.|.|...|..:|.|.|||
Frog   139 TKFNSFDAKLQ----DGATDVALKSTFFQKDKQFLVVQAAANLVPGKQYGLYTEFVGELADDLAG 199

  Fly   141 YYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNM-PVNET 204
            :|||.|:..  ..|:.|:.||.:...||.||||||||..||:|.|||.|.:.|..:||| .::.:
Frog   200 FYRSEYLED--GVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKYRQPYKAMSNMREIDRS 262

  Fly   205 RPHESIPDYVWTSFEESLPMSTYLVAYSLNDFS--HKPSTLPNGTL--FRTWARPNAI---DQCD 262
            ...|....:..:.|:::..||:||||:.:::|.  ..|.   |.|:  .:.|.|..||   :|.:
Frog   263 TVTEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGDPG---NATVTGVQIWGRKKAIQDENQGE 324

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            ||..:...:|.::.|.:...:||||.||:|:|||||||||||||||:.|:.||:..:.||...|:
Frog   325 YALSVTKPILDFFAEYYRTPYPLPKSDQVALPDFSAGAMENWGLVTYRETALLFDDQVSSIGNKE 389

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ....::||||||||||||||::||.|||||||||:||..|..:...|.|....|..::::..:..
Frog   390 RVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHRVMA 454

  Fly   393 KDSLESSHPI-SRPIEMT--SQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYK 454
            .|:|.||||: ||..|:.  |:||..||.|:|.||:|||||:..||.|..|..||.|||:.:.|.
Frog   455 VDALASSHPLTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYLKGFEYS 519

  Fly   455 NAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNT 519
            |....:||..|..|.:...::.....||.|||:|.||.|:||:.:    .:.|..::|:.:||:.
Frog   520 NTVYSDLWTHLQWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKI----DTATGVVTQKHFLLDP 580

  Fly   520 D--VSRA----HKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHD--LPGPDQWVI 576
            |  |:|.    :|  |.||:||....::|      ..|::    .||  :|:.|  :.|.| |::
Frog   581 DSVVTRPSPFDYK--WKVPISYKISSKED------NIWLQ----NES--ETVEDFKITGND-WLL 630

  Fly   577 FNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISY 641
            .|..::..|:||||..||..|:..|.: .:.:|.|:||||:|||....|...:.....||....|
Frog   631 VNLNVTGYYRVNYDDNNWSRLLNQLQT-SHQAIPVINRAQIIDDAFNLARAKQITTIQALDTTKY 694

  Fly   642 LERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL-----NGINDTVASEEQ 701
            :..:||.:||::|...|.:.:.:..:|..|...|.:.:..:.|::|:.     |..|..|:..:|
Frog   695 ISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLFEYFKQETGNWTNRPVSLTDQ 759

  Fly   702 --QDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCD 764
              :..|:      ..|||:::.||:..|...:..|.:....:.::|   .:|..|||||:..|.:
Frog   760 YCEINTL------STACSYDIEDCLKFASELFSQWMATPQQNNIHP---NLRTNVYCTAVAQGGE 815

  Fly   765 EDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSE 829
            ::|:|:|.|:|..::|.|:..:..:|.||:|.|:|.|:||.:.|.. .||:||:.|...::.::.
Frog   816 QEWNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNRFLEYSLDPT-MIRRQDAVSTISSVVNNP 879

  Fly   830 VGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQ-LKDIEQ 893
            :|..||..::.....::...:...|.|...|:..::.:..|:.:..:.:.|.|.:::. .....|
Frog   880 IGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRRFSTEFELQQLLQFKADNQNPGFGTASQ 944

  Fly   894 TISQSLETMLINVQWKERNYERFTRAISKHF 924
            .:.|::|....|:.|..:|    ..|:.|.|
Frog   945 ALEQAIEKTKANINWVNQN----KAAVKKWF 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	181/470 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	89/335 (27%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	181/471 (38%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	89/337 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110