DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and trhde.1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_001345457.3	Gene:	trhde.1 / 100006808	ZFINID:	ZDB-GENE-170406-2	Length:	994	Species:	Danio rerio

Alignment Length:	928	Identity:	310/928 - (33%)
Similarity:	493/928 - (53%)	Gaps:	73/928 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEI-TLSQ 87
            |.|||..|||:.||:|:...:||   |.|:|.|.|:.|.:.:|..|.|||..|.:|...: :.|:
Zfish   107 HLRLPATLRPRHYDLRLTVHMEN---FSFSGEVNIEFECVNSTKLIVLHSDRLELDKVLVFSDSK 168

  Fly    88 IGGEETTENCITSTAVNPTHDF-------YILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSS 145
            ..|           |:.....|       |::...:|:...:.|::::.|:|.::.:|.|::|||
Zfish   169 KAG-----------AMRIQRRFHYQPKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSS 222

  Fly   146 YVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESI 210
            |:  :..|.|:::||||.|..||.||||||||.|||:|.::|.:...|..||||||..|...|.
Zfish   223 YM--LNGERRFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDED- 284

  Fly   211 PDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAID--QCDYAAELGPKVLK 273
             .:|...|..:..||||.:|:::.:|::|.:...||.|.|.:|||:||.  ..|||..:..::|:
Zfish   285 -GWVTNHFSRTPRMSTYYLAWAVCNFTYKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQ 348

  Fly   274 YYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELA 338
            :|::.|.:|:.|||:|.:|||.....|||||||..|.|..:|..||.||...:.|...:|.||:.
Zfish   349 FYQDYFKVKYSLPKLDLLAVPKHPYSAMENWGLSVFVEQKILLDPEVSSFSYQMELTVVVVHEIC 413

  Fly   339 HQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLL-TIFRKDSLESSHPI 402
            |||||:|||..||.|:||.||||.|...:..:.:.|:|...:...::::| .:...|.|.|||||
Zfish   414 HQWFGDLVTPVWWEDVWLKEGFAHYFEYIGADFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPI 478

  Fly   403 SRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQ 467
            |:.:...:.|...||.|:|:||:::|||:...:|:..|:..|..||..:.|.||.:|:||..|::
Zfish   479 SQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSE 543

  Fly   468 AAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTR-DYTSRTAKLSQERYLLNTDVSRAHKGC--- 528
            |..:.|   ||.||..:||.||||.||||:.::: |....:..:|||.::.:||....:...
Zfish   544 AMQREG---KDINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNK 605

  Fly   529 ---WWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYD 590
               |.:||:......... :|....|:    |.:|....:..:.| :.|::.|...:..::||||
Zfish   606 SFQWQIPLTLAVGNASHI-STETIIWV----TNKSEAHRVGHMVG-ETWLLGNINQTGYFRVNYD 664

  Fly   591 AQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAF 655
            ..||||||:.|.|.. ..|.|.|||.|||||...|..|.....:.||:||||.:|.|.|||.:|.
Zfish   665 LHNWKLLIQQLMSNP-TIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQEPEFLPWHAAS 728

  Fly   656 DNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL---------NGINDTVASEEQQDKTILKAIV 711
            ..|..:..:|.:|.:...|.::..|.:.|.|..|         :.::....:||.|.:.|:
Zfish   729 RALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSFMHSAYQTEELQREVIM---- 789

  Fly   712 ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDED-WDFLWTRYQ 775
              .||||....|..||:|....|.|    ...|.:|..:|.:||||.:.. .||| |:|:|.::.
Zfish   790 --LACSFGNKHCHRQAVSLISDWIS----SNKNRIPPNVRDIVYCTGVSL-MDEDVWEFIWMKFH 847

  Fly   776 KANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGD-IRKQDSTSVFQAIADSEVGFLLAKKYL 839
            .:...:||:::|::|.||..:::|.|.|  |.....| :..||...|...:|.:.:|..||.:|.
Zfish   848 SSTAVSEKKVLLEALTCSDNIFLLNRLL--NLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYF 910

  Fly   840 MDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLI 904
            .:..|.::..|.......|:|:..::|.:.|:.:.:|...|:.:|..   :.....::::|.:..
Zfish   911 REKWDILNSRYGEALFMNSKLISGVTEFLNTEAELNELKEFILTSGG---ESAPAFARAVEIVQA 972

  Fly   905 NVQWKERNYERFTRAISK 922
            ||:|.....|:|.:.:.|
Zfish   973 NVKWHILFQEQFYQWLRK 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	174/465 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	102/338 (30%)
trhde.1	XP_001345457.3	Peptidase_M1	109..500	CDD:279741	154/408 (38%)
		M1_APN_2	118..568	CDD:189008	178/470 (38%)
		ERAP1_C	649..968	CDD:288671	100/335 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010