DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	961	Identity:	325/961 - (33%)
Similarity:	503/961 - (52%)	Gaps:	78/961 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKCVFLILAALGLSFAGEGS---------------TYDH------FRLPTALRPQSYDVRILTQL 44
            ||.:......||.:|.|..|               |..|      :|||..|.|..|::.:..:|
Zfish     1 MKRIHFSAMCLGCTFLGMASLATIVGLWTVQLLPTTESHVEPWKEYRLPDTLFPHYYNITLWPRL 65

  Fly    45 ENPDD---FHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQIGGEETTE-NCITSTAVNP 105
            : |||   :.|.|...:..:.|:.|..|.:|...|.:...:..|:::....|:| ..:..|.:..
Zfish    66 Q-PDDHGLYVFTGNSSVVFKCLRETDIIIIHCNKLNLTSEDGYLAKLSAFSTSEVPSVKKTWIEE 129

  Fly   106 THDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLA 170
            ...:.:|....:|.||:.|.|...|..:|.|.|||.|||.|...  .|.:.::.:|..|..||..
Zfish   130 MTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEYDED--GEKKIVATSQMHPTHARKT 192

  Fly   171 FPCFDEPGYKASFAITLGYHKKYTGLSN-MPVNETRPHESIPD---YVWTSFEESLPMSTYLVAY 231
            |||||||..||.|.|||.:.:....||| |.:...   ::|.|   ...|:||.:..||:||:|.
Zfish   193 FPCFDEPAMKAVFHITLIHDRGTVALSNGMEIENV---DTIVDGQPVTVTTFEPTKIMSSYLLAL 254

  Fly   232 SLNDFSHKPSTLPNGTLFRTWARPNAID--QCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVP 294
            .::|:::..|.  :|||.|.|||..||:  ..|||..:...:||::|..:.:.:||.|.||||:|
Zfish   255 VVSDYTNVTSA--DGTLIRIWARKKAIEDGHGDYALNITGPILKFFENYYNVPYPLSKSDQIALP 317

  Fly   295 DFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEG 359
            ||..|||||||||.:.||.|||.|..||...|:.||.|:||||||.|||||||:|||.::|||||
Zfish   318 DFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELAHMWFGNLVTLKWWNEVWLNEG 382

  Fly   360 FATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPIS---RPIEMTSQISESFDEISY 421
            ||:||:.|..:...|.|....|..:.::..:|..|:|.||||:|   ..|....||.|.||.:||
Zfish   383 FASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLSSKEEDIIKPEQIIEQFDTVSY 447

  Fly   422 QKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGS-LPKDYNIKTIM 485
            .||:||:||:..||.|..|..||.:||..:..:|...::||:.|..|.:|||: ||  .::|.||
Zfish   448 SKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWDHLQTAVNKTGTVLP--LSVKVIM 510

  Fly   486 DSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGC----WWVPLSYTNQEEKDFNNT 546
            |.|.||.|:||:.|    .:.|.::||..:||:.:.|......    |.||:::...:     ..
Zfish   511 DRWVLQMGFPVVTV----NTTTGQVSQMHFLLDPESSLQRTSPFNYEWIVPINWMKSK-----MV 566

  Fly   547 APKEW-MECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIH 610
            ..:.| :|.|.....:..|      ..:||:.|..::..|:||||..||:.|:..| :|::..|.
Zfish   567 QSRFWLLERTAVYNDMKTT------GSEWVLLNLNITGYYRVNYDIGNWERLLNQL-AENHKVIS 624

  Fly   611 VVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFK 675
            |:||||::||....|........:||:..:||..|||.:||:||.:||.:...:..||..:|..:
Zfish   625 VINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALNNLDYFYLMFTQTEVYRLLQ 689

  Fly   676 NFTRRLITPIYEHLNGIND---TVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSE 737
            ::|::.:||::::...|.:   .|.|........:.||  .:|||..|.:|.....|:|:.|..:
Zfish   690 SYTKKQVTPLFDYFKTITEDWSDVPSGHTDQYNQVNAI--RFACSTGVDECQNLTSSWYKQWMDQ 752

  Fly   738 ANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRY 802
            .|.   ||:...:|..|||:||..|..|:|||.||.::.|.:..:|  ::.||.|::...:|:||
Zfish   753 PNH---NPIHPNLRSTVYCSAIATGGAEEWDFGWTMFKNAAIEADK--LMSSLACAKNQTLLKRY 812

  Fly   803 LERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQ 867
            |....| ...|||||:|||...||.:..|..||.:::.:..:.:...|...|.:.:.|:..:::.
Zfish   813 LGYTLD-PSMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTEYGVGSFNFASLISGITKT 876

  Fly   868 IFTQRDYDEFMNFMA-SSKDQLKDIEQTISQSLETMLINVQWKERNYERFT 917
            ..|:.:.::.:.|.: :|:.........:.|::|....|::|...|.|..|
Zfish   877 FSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKWVAENQEDIT 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	186/468 (40%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	101/331 (31%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	162/410 (40%)
		M1_APN_2	57..520	CDD:189008	189/472 (40%)
		ERAP1_C	590..911	CDD:288671	99/329 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920