DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp1 and Usp38

DIOPT Version :9

Sequence 1:	NP_001263061.1	Gene:	Usp1 / 43462	FlyBaseID:	FBgn0028476	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_081830.2	Gene:	Usp38 / 74841	MGIID:	1922091	Length:	1042	Species:	Mus musculus

Alignment Length:	774	Identity:	154/774 - (19%)
Similarity:	230/774 - (29%)	Gaps:	291/774 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LCNIGNSCYLNSVVYTLRFAPHFLHNLHHLIQDLNVVQQTIVRQQTARSASLGKNVSAAQLEHAR 381
            |.|:||:||:|||:..|..|..|...:  |..:||                 |.|....:|:|..
Mouse   447 LINLGNTCYMNSVLQALFMATEFRRQV--LSLNLN-----------------GCNSLMKKLQHLF 492

  Fly   382 SWSSKDLATSTDQYSGQNGGVNSGNGGSGSSKSTHQSVTEKLHELYNNLHGNEMADSTEPYHADT 446
            ::.:.   |..:.|:.:.  ....:.....:..:.|..:|.|..|.:.||..|.
Mouse   493 AFLAH---TQREAYAPRI--FFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEEK----------- 541

  Fly   447 LLHAIQDVNATFEGNQQQDAHEFLMCVLNCIRETNQSLIKAIGECPEVIANGYIANPDE-VDTGE 510
             :..:|..:...||         |.|...|::|....                :|.|.| ..||:
Mouse   542 -ILRVQSSHKPSEG---------LDCAETCLQEVTSK----------------VAVPTESPGTGD 580

  Fly   511 -----------GQDRTDSTASQNLNAGNGSLATSQTTTTKTSFFSRKSKRKDEVKPSKSTRVQSP 564
                       |:.||....   ||.|:.|......|....:|.           ||.|..
Mouse   581 SEKTLIEKMFGGKLRTHICC---LNCGSTSHKVEAFTDLSLAFC-----------PSPSVE---- 627

  Fly   565 LKENSPTAGGITGAGTAHATANSLFYLNTVDLSGASSTSGSASTSASGVVSTSAALPTP------ 623
                                          ||| ...|:...|....|::.||.|.|..
Mouse   628 ------------------------------DLS-FQDTASLPSAQDDGLMQTSVADPEEEPVVYN 661

  Fly   624 PQATKYSSDDEMNSATVLKDKMRLEERIRELNLNFFSSDFEGIVVLTTKCLSCETITRQKQGMLD 688
            |....:..|..:|...:                        |...:...|....::..:...:|
Mouse   662 PATAAFVCDSVVNQRVL------------------------GSPPVEFHCAESSSVPEESAKIL- 701

  Fly   689 ISVPVPIS--GYDNADLQDKPSTYIQNSCITKEYFRGENKYSCNQCTGYTEAIRSISYEVLPRLL 751
            ||..||.:  |.....:.|     :.|..:..|...|||:|.|..|.....|.:::.....|..|
Mouse   702 ISKDVPQNPGGESTTSVTD-----LLNYFLAPEVLTGENQYYCESCASLQNAEKTMQITEEPEYL 761

  Fly   752 VIQLNRFSGG---------MEKVSTYVPTTFTLP------------------------------- 776
            ::.|.|||..         ::.||  :|....||
Mouse   762 ILTLLRFSYDQKYHVRRKILDNVS--LPLVLELPVKRTASFSSLSQSWSVDVDFTDINENLPKKL 824

  Fly   777 -------CFCATCCELGEGNKLHVYKLYSVITHVGATLTVGHYIAYT-CFLDLASDYVNCPKDRR 833
                   .||.         ||..|.|.||:.|.|.:...|||.:|. ......|.|..||:...
Mouse   825 KPSGTEEAFCP---------KLVPYLLSSVVVHSGVSSESGHYYSYARNITGTESSYQMCPQSES 880

  Fly   834 NTMTNSQ----------TMASQAVPSNENAAP----NNGS---SSVASTPVIAAASALASSGNIL 881
            ..:..||          |:..|.:.:.|.:..    |:..   :|..|...|.:.....::..:|
Mouse   881 LALAPSQSCLLGVESPNTVIEQDLENKEMSQEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLL 945

  Fly   882 MKKMKFGRSKASSSGDMSKNVKQVNGIISKNITNGI-------------------GKLSISTTCQ 927
            .||    :|:|             |||.|.|..:|:                   .||.:..  |
Mouse   946 YKK----QSRA-------------NGIDSDNPASGVWANGDPPLQKELMDAITKDNKLYLQE--Q 991

  Fly   928 GVNCCAMRLCCTQQTSSSNSTSCSDFSEESLQNGSNSNLSFGGSGSTYPTGYGSTGRGG 986
            .:|..|..|       .:.|.|||     ...||.:.|   ...||..|||.|  |.||
Mouse   992 ELNARARAL-------QAASASCS-----FRPNGFDDN---DPPGSCGPTGGG--GGGG 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_001263061.1	Peptidase_C19	308..819	CDD:271592	108/569 (19%)
Usp38	NP_081830.2	UCH	445..946	CDD:278850	121/649 (19%)
Usp38	NP_081830.2	Peptidase_C19H	446..947	CDD:239129	122/650 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900