Protein Alignment Usp1 and USP35

DIOPT Version :10

• Sequence 1: NP_651687.3
• Gene: Usp1 / 43462
• FlyBaseID: FBgn0028476
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_065849.1
• Gene: USP35 / 57558
• HGNCID: 20061
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 134/710 - (18%)
• Similarity: 233/710 - (32%)
• Gaps: 207/710 - (29%)

  Fly   308 LNHAPSM-GTL----CNIGNSC--YLNSVVYTLRFA----PHFLHNLHHLIQDLNVVQQTIVRQQ 361
            |.|.|.| .:|    .|.|.||  .|..:|:.:.|.    |.....:...|:||:|..:..::|
Human   348 LPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQ- 411

  Fly   362 TARSASLGKNVSAAQLEHARSWSSKDLATSTDQYSGQNGGVNSGNGGSGSS-------------- 412
                 .||::...:|......:..:.:|.|.   :|:.|.:|.||....:|
Human   412 -----LLGQDAWTSQKSELAGFYPRLMAKSD---TGKIGLINLGNTCYVNSILQALFMASDFRHC 468

  Fly   413 -----KSTHQSVTEKLHELYNNL-HGNEMADSTEPYHADTLLHAIQDVNAT----FEGNQQQDAH 467
                 ::..|.:..||..|:..| |....|.|.|.:           ::|:    |....|||..
Human   469 VLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENF-----------LSASWTPWFSPGTQQDCS 522

  Fly   468 EFLMCVLNCIRETNQSLIKAIGECPEVIANGYIANPDEVDTGEGQDRTDSTASQNLNAG------ 526
            |:|..:|:.:.|..::..:.   |.::..:...:.|:|      .....||:.:.:..|
Human   523 EYLKYLLDRLHEEEKTGTRI---CQKLKQSSSPSPPEE------PPAPSSTSVEKMFGGKIVTRI 578

  Fly   527 ------NGSLATSQTTTTKTSF----FSRKSKRKDEVKPSKS---------TRVQSP-------- 564
                  |.|......|....:|    ..|:.:....::|::.         |..|.|
Human   579 CCLCCLNVSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQ 643

  Fly   565 -----LKENSPTAGGITGAGTAHATANSLFYLNTVDLSGASSTSGSASTSASGVVSTSAALPTPP 624
                 .::..||:..|.|             |::.:..|.||..........|          ..
Human   644 RKHCITEDTPPTSLYIEG-------------LDSKEAGGQSSQEERIEREEEG----------KE 685

  Fly   625 QATKYSSDDEMNSATVLKDKMRLEERIRELNLNFFSSDFEGIVVLTTKCLSCETITRQKQGML-- 687
            :.|:.....|...:|..:.:...||.:.|        :.|.:...|.|    |....:::..|
Human   686 ERTEKEEVGEEEESTRGEGEREKEEEVEE--------EEEKVEKETEK----EAEQEKEEDSLGA 738

  Fly   688 ----DISVPVPISGYDNADLQDKPSTY-IQNSCITKEYFRGENKYSCNQCTGYTEAIRSISYEVL 747
                |.::|   ||......:...|.. :.|..::.|....||:|.|..|....:|.:.:.....
Human   739 GTHPDAAIP---SGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQG 800

  Fly   748 PRLLVIQLNRFSGGMEKV-------STYVPTTFTLPCFCATCCELGEGNKLHVYKLYSVITHVGA 805
            |..|::.|.|||..:..:       ...:|....||.         .|.:...|.|.||:.|.|.
Human   801 PCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPL---------AGGRGQAYDLCSVVVHSGV 856

  Fly   806 TLTVGHY----------------------------------IAYTCFLDLASDYVNCPKDRRNTM 836
            :...|||                                  ::::.|..:::.....|||....:
Human   857 SSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVL 921

  Fly   837 TNSQTMASQAVPSNENAAPNNGSSSVASTPVIAAASALA-SSGNI--LMKKMKFGRSKAS 893
            ...|.       ..|......|||.|.:.|.:......| |..||  |.::.|..||:|:
Human   922 FYRQR-------PREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYLQEQEKEARSRAA 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_651687.3	Peptidase_C19	308..819	CDD:470612	114/631 (18%)
USP35	NP_065849.1	COG1365	<55..97	CDD:440976
		Peptidase_C19	442..924	CDD:470612	94/548 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	544..566		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..757		28/184 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	984..1011