DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp1 and usp38

DIOPT Version :9

Sequence 1:	NP_001263061.1	Gene:	Usp1 / 43462	FlyBaseID:	FBgn0028476	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_003197722.1	Gene:	usp38 / 563778	ZFINID:	ZDB-GENE-101007-2	Length:	1014	Species:	Danio rerio

Alignment Length:	804	Identity:	137/804 - (17%)
Similarity:	221/804 - (27%)	Gaps:	368/804 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LCNIGNSCYLNSVVYTLRFAPHFLHNLHHLIQDLNVVQQTIVRQQTARSASLGKNVSAAQLEHAR 381
            |.|:||:||:||::..|..|..|..::..|
Zfish   447 LVNLGNTCYMNSILQILFMATDFRRHVMSL----------------------------------- 476

  Fly   382 SWSSKDLATSTDQYSGQNGGVNSGNGGSGSSKSTHQSVTEKLHELYNNL-HGNEMADSTEPYHAD 445
                        |.:|.|                  ::.:||..|:..| |....|.|...:
Zfish   477 ------------QLNGSN------------------TLMKKLQLLFAFLAHTQRAAYSPRSF--- 508

  Fly   446 TLLHAIQDVN--ATFEGNQQQDAHEFLMCVLNCIRETNQSLI---------KAIGECPEVIANGY 499
                  .||:  ..|....|||..|:|..:|:.:.|..::|.         :.....||.:.|..
Zfish   509 ------LDVSRPTWFSAGSQQDCSEYLRFLLDRLHEEEKALSALQTASPKPEPATTSPETLHNAV 567

  Fly   500 ---IAN-PDEVDTGEGQDRTD-----------STASQNLNAGNGSLATSQTTTTKTSFFSRKSKR 549
               |:: |...|....|..|.           |||.:.|...:.|......|....:|....|:.
Zfish   568 SPPISDVPSHPDPAAAQGETGTLVERMFGGRLSTAIRCLQCHSLSEKEEPFTDLSLAFCPSMSQP 632

  Fly   550 KDEVKPSKSTRVQSPLKENSPTAGGITGAGTAHATANSLFYLNTVDLSGASSTSGSASTSASGVV 614
            :......||:....|.:      |.:.|                    |:.::.|.....|:..:
Zfish   633 RGPTNEHKSSSTLGPCQ------GAVNG--------------------GSEASEGPVKEGAASGM 671

  Fly   615 STSAALPTPPQATKYSSDDEMNSATVLKDKMRLEERIRELNLNFFSSDFEGIVVLTTKCLSCETI 679
            ......||
Zfish   672 ERPMVEPT--------------------------------------------------------- 679

  Fly   680 TRQKQGMLDISVPVPISGYDNADLQDKPSTYIQNSCITKEYFRGENKYSCNQCTGYTEAIRSISY 744
                     ||||         ||.|    |.    :..|....||.|.|.:|.....|.:::..
Zfish   680 ---------ISVP---------DLVD----YF----LAPEILENENCYFCERCASLQRAEKAMRV 718

  Fly   745 EVLPRLLVIQLNRFSGGMEKVSTYVPTTFTLPCFCATCCELGEGNKLHVYKLYSVITHVGATLTV 809
            ...|..|::.|.|||                  :.|||         ||.:  .::.:||..|
Zfish   719 VAAPEYLILTLLRFS------------------YDATC---------HVRR--KILDNVGIPL-- 752

  Fly   810 GHYIAYTCFLDLASDYVNCPKDRRNTMTNSQTMASQAVPSN---ENAA----------------- 854
                           :::.|..:.::.::|...||.:..|.   ||.|
Zfish   753 ---------------HMSLPLHQHSSSSSSNVAASSSTESPDSCENLAKKLKPSQKEEGIAESRM 802

  Fly   855 ---PNNGSSSVASTPVIAAASALAS-----SGNILMKKMKFGRSKASSSGDMSKNVKQVNGIISK 911
               .||......|.|.:.::..:.|     ||:.    ..:||:.:|..|
Zfish   803 KSKKNNSDLQKLSVPYVLSSVVMHSGMSSDSGHY----YSYGRNVSSDDG--------------- 848

  Fly   912 NITNGIGKLSISTTCQGVNCCAMRLCCTQQTSSSNSTSCSDFSEESLQNGSNSNLSFGGSGSTYP 976
                                      |...|           |.:||.|.|.|      ..||.|
Zfish   849 --------------------------CVAHT-----------SPKSLDNSSQS------ESSTAP 870

  Fly   977 TGYGSTGRGGVRANYAHGGPDP---IWYMCDDDKIKAMTQREFEELLSPTRKI-TITPYLLFYAR 1037
              ...|||.           ||   .|::.:|.::   |...|:.|.:.|.:. ..|.|:|.|.:
Zfish   871 --QEETGRA-----------DPKSADWFLFNDSRV---TFTNFQSLQNVTSRFPKDTAYVLIYRK 919

  Fly  1038 FDL--QPQKATPPMPGSSTTPPPP 1059
            .::  :...:.|.:.|:..:..||
Zfish   920 QEVSGEASNSGPVVNGARLSGEPP 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_001263061.1	Peptidase_C19	308..819	CDD:271592	88/528 (17%)
usp38	XP_003197722.1	UCH	445..917	CDD:278850	132/776 (17%)
usp38	XP_003197722.1	Peptidase_C19H	446..918	CDD:239129	132/777 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900