DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp1 and puf

DIOPT Version :9

Sequence 1:	NP_001263061.1	Gene:	Usp1 / 43462	FlyBaseID:	FBgn0028476	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster

Alignment Length:	1027	Identity:	185/1027 - (18%)
Similarity:	313/1027 - (30%)	Gaps:	366/1027 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PASLPPTQNETTEINSQLRQDQQNQEQENPLRQQDNSHPPQENPINQQEKDTLQVSVLYPLVVCA 77
            |..|...::..|:::...:.|...:|::...:::.         |.|:.:|.|..:.|...:...
  Fly  1425 PHILDAFKSLVTDLSELEQLDAGGEEEQLATKRKQ---------IKQKFRDLLDPNNLQKFMYSL 1480

  Fly    78 QLADSQLVLTA-------------DTPKLSPVKKRQRRVYVADTLRCYSLRSRQEPATKDPLEGG 129
            .:.:| |.||:             :||:...|||              |...|:..:.:.|
  Fly  1481 HIVES-LALTSSRRGESNGNVAMGNTPEQVRVKK--------------SSMGRRRNSNEQP---- 1526

  Fly   130 LKQPDVVPPPPP-----------VQAP-SPTP--------TEST-------EYTPPEQFKSEFWN 167
                   |||||           ::|| :|||        ||::       |..|.:..|.:...
  Fly  1527 -------PPPPPEVKMSKEQLCELEAPLTPTPSTGLQDVETEASSSSGGDKENQPKQHSKRQKKG 1584

  Fly   168 RIEEAQEPKPVG---KKRRTP----------------------GGLKRTRGNKLLKELEIQS--- 204
            ...|.::.:|||   ....||                      |||:..  .::..|.::|.
  Fly  1585 ETFEQEKERPVGCSTPPSPTPPPPALSVVERGDNKWSEAFVKCGGLRHL--YEIFSEGQLQQSAH 1647

  Fly   205 PETAA-------AIAAAQAELNAAG----KSGAAGARSSRKRTNTMSLYDRRFQTTTEERRVANG 258
            |:..|       .:|:....|...|    :|..|....||.....:.|.:.. |..|   |:::.
  Fly  1648 PKELALNEWRHDCLASLLRILWLLGFEELQSADAHVLMSRPHPFMLQLMEVP-QCLT---RLSSI 1708

  Fly   259 YGGNAARSVTGSSSNEIESQEPQSHQYYGPNG-------GSNAAGAGAGLNGSAAALNHAPSMGT 316
            ......:....||:|.:.......|...|..|       ..|...:....:..|..|..||: ||
  Fly  1709 LNDEVHQQHQASSANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLWAPT-GT 1772

  Fly   317 ---------------------LC-NIGNSCYLNSVVYTLRFAPHFLHNLHHLIQDLNVVQQTIVR 359
                                 :| .:...|..|:..|.|..||    .||.||..|.:.:|
  Fly  1773 DHCRWLQKFILEDPEPAVRREICAGLYRICLGNAHSYRLLLAP----LLHKLIALLPLAEQ---- 1829

  Fly   360 QQTARSASLGKNVSAAQLEHAR---SWSSKD------------LATSTDQYSGQNGGVNSGNGGS 409
                  .|.|.       :|.:   |...||            ||...|..|.:
  Fly  1830 ------MSSGN-------QHTQFLLSEEGKDPYGPACRDYFWLLARLVDTLSPE----------- 1870

  Fly   410 GSSKSTH-------QSVTEKL--HELYNNLHGNEMADSTEPYHADTLLHAIQDVNATFEGNQQQD 465
             .....|       :|:::.:  .|.|...||         |..|.|:..:.
  Fly  1871 -MVAEEHIDIEMLCESISQSILTREYYELRHG---------YQDDGLVGLLN------------- 1912

  Fly   466 AHEFLMCVLNCIRETNQSLIKAIGECPEVIANGYIAN-PDEVDTGEGQDRTDSTASQNLNAGNGS 529
                ||..|.....|.:...||:....::|  |::.: |...|.   |.....:||...:|.:..
  Fly  1913 ----LMSNLIKYDTTFKYTPKALSFIEQLI--GFLFDMPSPADR---QKPKCKSASSRASAYDLL 1968

  Fly   530 LATSQTTTTKTSFFSRKSKRKDEVKPSKSTRVQS-PLKENSPTAG--GITGAGTAHATANSLFYL 591
            :...:...|..::...:...:.:..|.:...... |..|.....|  |:|..|.....|:.:.:|
  Fly  1969 VELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGATCYMASCVQHL 2033

  Fly   592 NTVDLSGASSTSGSASTSASGVVSTSAALPTPPQATK---------------------------- 628
            ..:..:.|                  |.|..||.|.:
  Fly  2034 YMMPQARA------------------AVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRS 2080

  Fly   629 ----YSSDDEMNSATVLKDK--------MRLEER---IRELNLNFFSSDFEGIVVLTTKCLSCET 678
                |..|.:..:....||.        .:||:.   ::.|....|.......||    .|.|..
  Fly  2081 FCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLKHLVKRLFCGSLSNNVV----SLDCGH 2141

  Fly   679 ITRQKQGMLDISVPVPISGYDNADLQDKPSTYIQNSCITKEYFRGENKYSCNQCTGYTEAIRSIS 743
            ::|..:....:...|.    |..:||:.     .:....|:...|:|.|:|:||.....|.:...
  Fly  2142 VSRTAEDFYTVRCQVA----DMRNLQES-----LDEVTVKDTLEGDNMYTCSQCGKKVRAEKRAC 2197

  Fly   744 YEVLPRLLVIQLNRFSGGM-----EKVSTYVPTTFTLPCFCATCCEL------------------ 785
            ::.||::|.....|::..|     |||:|:    |:.|.....|..:
  Fly  2198 FKKLPQILCFNTMRYTFNMVTMLKEKVNTH----FSFPLRLNMCHYVEKTLMPQQYKEERERRQK 2258

  Fly   786 --------GEGN--------------KLHVYKLYSVITHVGATLTVGHYIAY 815
                    |:||              :.:.|:|..|..|.| |...|||.::
  Fly  2259 EKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG-TADGGHYYSF 2309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp1	NP_001263061.1	Peptidase_C19	308..819	CDD:271592	116/646 (18%)
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	61/333 (18%)
		UCH	2014..2377	CDD:278850	60/332 (18%)
		DUF3517	2723..>2877	CDD:288853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100