DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and BDF1

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_013503.1	Gene:	BDF1 / 851115	SGDID:	S000004391	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	799	Identity:	159/799 - (19%)
Similarity:	257/799 - (32%)	Gaps:	265/799 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QNWITVSRTLKTICGNG-----SSN--RPADWFSQKNCAMQYGNLLESVEATKR---KKRSSESS 91
            ||.:.|:       ||.     |||  ||.|.....|     |...|...|..:   ||...:..
Yeast     8 QNDVDVN-------GNNVNDDVSSNLKRPIDQGDPSN-----GLAEEENPANNQLHLKKARLDGD 60

  Fly    92 AGVSSPA-TVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQDMWL 155
            |..|||| ..|...|........|..........:|::...:.:...:..:.:.:.|...|::.:
Yeast    61 ALTSSPAGLAENGIEGATLAANGENGYNATGSGAEDEQQGLKKEEGGQGTKQEDLDENSKQELPM 125

  Fly   156 EIEKEQEARRIEEMKL----ENRMREREQRKKDLASNWRNSSLAVKRSN------QAADTTSVD- 209
            |:.||.......|..:    :|.:.:.:|:...||..      ||||..      |..|...:|
Yeast   126 EVPKEPAPAPPPEPDMNNLPQNPIPKHQQKHALLAIK------AVKRLKDARPFLQPVDPVKLDI 184

  Fly   210 ----------MDV-------------------EDINTS-GNGKQQTGPSPLLTSLLKSPTG---- 240
                      ||:                   ||.|.. .|..:..||:..::.:.::...
Yeast   185 PFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEK 249

  Fly   241 ---NAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPI 302
               |.||...|                  |.|..   ...|||..:.|::..::.|......|.|
Yeast   250 HMLNMPAKDAP------------------PVIAK---GRRSSAQEDAPIVIRRAQTHNGRPKRTI 293

  Fly   303 TGPPASE-----ASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEA 362
             .||.|:     .|..|..:|. .||......:|::.||...|:.:...::|         ||..
Yeast   294 -HPPKSKDIYPYESKKPKSKRL-QQAMKFCQSVLKELMAKKHASYNYPFLEP---------VDPV 347

  Fly   363 TSSAAGTAD-----------SDEADPNEAQLLE--------VFKN-----------------IDQ 391
            :.:.....|           :.:.:..:.|.:|        ||||                 :::
Yeast   348 SMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEE 412

  Fly   392 I----------IDDIDIDMASVIDDEILKNVDD-------------VVASPSNDKAEVIDFEDKL 433
            :          :||.|.|.    |.....:.||             ::.:|:     :...|::|
Yeast   413 VFNSKWADRPNLDDYDSDE----DSRTQGDYDDYESEYSESDIDETIITNPA-----IQYLEEQL 468

  Fly   434 DALKRE--QSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAES 496
            ..:|.|  |.|........|...|..||..           ..:.||.|..|...|::|..|.::
Yeast   469 ARMKVELQQLKKQELEKIRKERRLARGSKK-----------RGKRSKGRSGSKNASSKGRRDKKN 522

  Fly   497 EPLTSEVAVEE---IGETITIISTSSEDTA-----GSPPTKMEEDGATDSLPKKEDAAEDKS--- 550
            : |.:.|..:.   |.|.|..:.||..:.|     .|.|...|:|.....|    |..::.:
Yeast   523 K-LKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDL----DTLDNHTILT 582

  Fly   551 -------EQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPV 608
                   :.||||...|...|::.        .||:|.|.|  .|:......:.|..:|
Yeast   583 LYNTFFRQYESSSGASNGLDGTSG--------VTRDASSLS--PTSAGSRKRRSKALSQ------ 631

  Fly   609 DLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLP 673
                  ||.|...:..|:              |||:.||.|.|..:|:|..         ::...
Yeast   632 ------EEQSRQIEKIKN--------------KLAILDSASPLSQNGSPGQ---------IQSAA 667

  Fly   674 HRDRSESPMVDDDATTASD 692
            |...|.|.  |||.::.|:
Yeast   668 HNGFSSSS--DDDVSSESE 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	13/86 (15%)
		PHA03249	402..>582	CDD:223023	44/212 (21%)
		Bromo_brd8_like	729..833	CDD:99939
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	80/414 (19%)
		Bromodomain	<339..417	CDD:413371	10/86 (12%)
		PTZ00108	<386..647	CDD:240271	63/321 (20%)
		BET	527..589	CDD:407211	13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810