DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and cecr2

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_005174419.1	Gene:	cecr2 / 799918	ZFINID:	ZDB-GENE-131121-533	Length:	1502	Species:	Danio rerio

Alignment Length:	877	Identity:	161/877 - (18%)
Similarity:	267/877 - (30%)	Gaps:	308/877 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LESVEATKRKKRSSESSAGVSSPATVETPTELL-LRRLTEERQAEIKAQMRQDQETYRRIQREIE 138
            :::||...|:::..|..|.:.|... |.|.||| |...:..|:|....|..:..:.|..:.:.:|
Zfish   350 VKAVEERARRRKQREEKAWLLSQGK-ELPPELLNLETHSPIRRARRTKQFYEIDDDYTALYKVLE 413

  Fly   139 SLQSDAVTEQELQDMW--LEIEKEQEARRIEEM--------KLENRMREREQRKKD--------- 184
            :|::.       :|.|  :|...|..|....|:        .:|.::.:.|...||
Zfish   414 ALKAH-------KDAWPFMEPVDESYAPNYHEIIQTPMDLSTIERKLNDGEYLAKDEFVADVKLM 471

  Fly   185 ----LASNWRNSSLAVKRSNQAADTT--------SVDMDV-EDINTSGNGK---------QQTGP 227
                |..|...|...:...:.....|        |.|.|. |:.:.|...:         :|:||
Zfish   472 FGNCLEYNGEESEYTIMAESLERCFTRALLKHFPSEDGDTDEEFHVSSEDRKDKKKNKNHKQSGP 536

  Fly   228 SPLL-------------------------TSLLKSPT---GNAPATPTPGGAAPAAGGTGSVARA 264
            ..|:                         .|.|:.|.   .|.|  |.|....|.....|.:
Zfish   537 ESLIRATEQVQKRKTSNSGKGNNQQQEKPKSTLQPPPPHYSNGP--PHPHNIHPGQQQRGML--- 596

  Fly   265 TAPTITSLLTSGPSSAVANQPV-ITMKSPTDAAFMSRP------------------ITGP----- 305
             .|.......|||.....:..: .....|.....:|||                  |.||
Zfish   597 -HPAQQFQRPSGPGMYAQHMMIDAQYPYPGQRPLISRPPGDHENQHVPHFNMQGSHINGPHLGTR 660

  Fly   306 ----PASEASTTPTLERSPS--QAAPTLS---MLL----------EKNMAAAKANESGSLVKPEG 351
                |..:....|..:.|.|  ...|:|.   |.|          |.||..:..:..|..::|.|
Zfish   661 YTVGPDGQPLQPPHQQHSYSGPTHGPSLGPRPMALQPGGLCSPPPEGNMYPSHQHPEGQSMRPMG 725

  Fly   352 SGNQEQGVDEATS----------------------------------SAAG-------------- 368
            :.....||...:|                                  ||:|
Zfish   726 NAYTRPGVPMHSSYPPYGPHGMNIPRMWPPMNHQRQPTPSGNMMQEPSASGQHPYNHNMIHSQNS 790

  Fly   369 -------------TADSD-------EADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVD 413
                         :|:|.       :..|..::|                .:||::|...:..:.
Zfish   791 TGFTMANGQFKMPSANSQGPVGQKLQGGPQASRL----------------HLASMLDSPEMIALQ 839

  Fly   414 DVVASPSNDKAEVIDFEDKLDALKREQSKSSP-ASDKPKSVELVIGSSDDSNDNIPLAAVASQES 477
            .:.||.|:   .|.:|:..      :||..:| ||.:..|.|..:........:.|:::..|...
Zfish   840 QLSASSSH---HVGNFQSP------QQSGGNPLASAEQSSPEKQLHMPSRDKQHTPVSSKGSSPK 895

  Fly   478 KDRGQSGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSS--------------------EDT 522
            .....|.||.:....::.|.|.|:|.: |:..:...:.|.||                    .|.
Zfish   896 SGNKMSTGEISLTEAESRSYPSTTEKS-EQPSQVTGLASVSSPSKELNQNEDKHRLSNLEKIHDQ 959

  Fly   523 AGS---PPTKMEEDGATDSLPKKEDAAEDKSEQE---SSSQGQNKAGGSTDEPELIDHQATREAQ 581
            ..|   ||.....||.:..|...:.... |::.:   :.||..||..    .|::|.:.:.|::|
Zfish   960 LNSQLGPPNLKSVDGFSFPLNSPQPMPH-KTQDDIPLNISQQINKHA----LPQIIQNGSQRQSQ 1019

  Fly   582 SKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDD 646
            :...:.....|..|.|..          :|   :...|::...::::..|..:..|
Zfish  1020 NVPPQILQNIPQQMTENV----------IH---QYHQSVSQQIQNNESVRGPQVGP--------- 1062

  Fly   647 SKSELELSGTPQ-------------------PPSAPARTPLLRKLPHRDRSESP------MVDDD 686
                  |.|.||                   |||.|...||.:..|.....:.|      .|.|.
Zfish  1063 ------LHGMPQISSQGGQPGVHQPATLSSLPPSHPVSHPLAQPSPADQGDQRPCEPTSRKVSDG 1121

  Fly   687 ATTASDHSTARSTRRRCSSTPVIDSIPNSPAS 718
            :|.:.|.|.| :.|..|:|...... |.||.|
Zfish  1122 STASQDGSNA-NLRTDCTSGQYKQQ-PFSPES 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	21/106 (20%)
		PHA03249	402..>582	CDD:223023	42/206 (20%)
		Bromo_brd8_like	729..833	CDD:99939
cecr2	XP_005174419.1	DDT	23..63	CDD:280886
		ARGLU	202..366	CDD:291991	4/15 (27%)
		Bromo_gcn5_like	403..503	CDD:99941	17/106 (16%)
		Med15	675..>1110	CDD:255446	84/493 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900