Protein Alignment Brd8 and Brd8

DIOPT Version :10

• Sequence 1: NP_651685.2
• Gene: Brd8 / 43460
• FlyBaseID: FBgn0039654
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_001348065.1
• Gene: Brd8 / 78656
• MGIID: 1925906
• Length: 954
• Species: Mus musculus
• Alignment Length: 1047
• Identity: 258/1047 - (24%)
• Similarity: 396/1047 - (37%)
• Gaps: 322/1047 - (30%)

  Fly     1 MSAGVQERLQLSRMPLDTWSKREQLILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQK 65
            |:.|..:...||..|.:.||.||:|.|||:|..||||||::|||.:|.....|   ||.||||||
Mouse     1 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPG---RPPDWFSQK 62

  Fly    66 NCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETY 130
            :||.||..|||:.|..|||:.....        .|||..::::|:||.||..|:|..:::.||.|
Mouse    63 HCASQYSELLETTETPKRKRGEKGE--------VVETVEDVIVRKLTAERVEELKKVIKETQERY 119

  Fly   131 RRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLA 195
            ||::|:.|.:|:..: :..|.::..:|..::        |||....|.:::..|.|...|.   |
Mouse   120 RRLKRDAELIQAGHM-DSRLDELCNDIAMKK--------KLEEEEAEVKRKATDAAYQARQ---A 172

  Fly   196 VKRSNQAADTTSVDMDVEDINTSGN---------------------------------------- 220
            ||...:...|..|...|:..:..|:
Mouse   173 VKTPPRRLPTVMVRSPVDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPP 237

  Fly   221 ----------------------GKQQT-GPSPLLTSLLKS----PTG----NAPATPTP------ 248
                                  |::.| .|||||:.|||.    ||.    |....|.|
Mouse   238 GSAPLEAPMTPITDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMPVPPGHLNS 302

  Fly   249 -------GGAAPAAGG----------TGSVARATAPTITSLLTSGPS---------SAVANQPVI 287
                   ||..|...|          ..|.|.:.|||::.||.:||:         :.||::|.:
Mouse   303 TGVLLEVGGVLPMIHGGEIQPTTSAVAASPAASGAPTLSRLLEAGPTQFTTPLPSFTTVASEPPV 367

  Fly   288 TMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLV-KPEG 351
            .:.              ||..|:.:..|:...|:..||:       :.||...:|||:.| :||.
Mouse   368 KLV--------------PPPVESVSQATIVMMPALPAPS-------SAAAVSTSESGAPVSQPEP 411

  Fly   352 SGNQEQGVDEATSSAAGTADSDEADPNEAQLL------EVFKN----------IDQIIDDIDIDM 400
            ....|...|..|.:.:       .|.||..::      |.|::          ...|....|:|:
Mouse   412 CVPLEAVGDPHTVTVS-------MDSNEISMIINSIKEECFRSGVAEAPGGSKAPSIDGKEDLDL 469

  Fly   401 ASVID-------DEI-LKNVDDVVA---SPSNDKAEVIDFEDKLDALKREQSKSSPAS------- 447
            |..:|       :|: .:.|.|::|   ...:|..||:|......||...:....|.|
Mouse   470 AEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEH 534

  Fly   448 ------DKPKSVELVIGSSDDSNDNIPLAA---VASQESKDRGQSGGESTRGTEDAESEPLTSEV 503
                  |||                :||.|   ...||..|           .|::|::.|...|
Mouse   535 PIQQERDKP----------------VPLPAPEMTVKQERLD-----------FEESENKGLHDLV 572

  Fly   504 AVEEIGETITIIST-------SSEDTAG-------SPPTKMEEDGATDSLPKKEDAAEDKSEQES 554
            .:.:.|..|.:..|       .:|..||       .||....:|  :|..| :..||.|..|.:.
Mouse   573 DIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSMEPPELRSQD--SDEEP-RSSAAGDIGEADG 634

  Fly   555 SSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSA---PVPVDLHDTDEE 616
            ||       |..||..|            |...|...|.:|...:...:.   |:..:.....|.
Mouse   635 SS-------GKGDERPL------------SAVKTEASPESMLSPSHGSNLIEDPLEAETQHKFEM 680

  Fly   617 SSSLTDSS-----------KHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSAPARTPLLR 670
            |.||.:.|           ..||......::..:|:...::.:.|..||.....|..
Mouse   681 SDSLKEESGTIFGSQIKDAPGDDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPV-------- 737

  Fly   671 KLPHRDRSESPMVDDDA-----TTASDHSTARSTRRRCSSTPVIDSIPNSPASSEH---TDDRRE 727
                   |||    ||.     .|...|:.|             ||||:|||||:.   ::|:..
Mouse   738 -------SES----DDGFSIHNATLQSHTLA-------------DSIPSSPASSQFSVCSEDQEA 778

  Fly   728 TRAAS--KKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLS 790
            .:|..  ||..:.::....:.::|..|.:|..|:.|..:..:..||||..|||:||::|.|||.:
Mouse   779 IQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTA 843

  Fly   791 ELHRDVLLMAHN-VLVAYKPHTAQHKTARLFVQDCQAIKEF--SQL--PDVQAGITATPVSNTGS 850
            |..||::||..| |:.....|...|....:.....:.|::|  :||  ...::||:|..:....|
Mouse   844 EFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDS 908

  Fly   851 LRADKSS 857
            .|...:|
Mouse   909 TRKQDAS 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PTZ00108	<111..367	CDD:240271	79/359 (22%)
		PHA03307	403..>708	CDD:223039	72/364 (20%)
		Bromo_brd8_like	729..833	CDD:99939	32/108 (30%)
Brd8	NP_001348065.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..273		38/205 (19%)
		PHA03247	<176..356	CDD:223021	57/283 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..547		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..745		38/184 (21%)
		Bromo_brd8_like	782..885	CDD:99939	23/81 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..922