DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Pbrm1

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001074720.1	Gene:	Pbrm1 / 66923	MGIID:	1923998	Length:	1704	Species:	Mus musculus

Alignment Length:	857	Identity:	156/857 - (18%)
Similarity:	277/857 - (32%)	Gaps:	280/857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 RKKRSSESSAGVSSP-----ATVETP-TELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQ 141
            :::|::..|:.||..     .:|.|| .....|||:.....:..|...:...|.|..:.|...|
Mouse     4 KRRRATSPSSSVSGDFDDGHHSVPTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRL- 67

  Fly   142 SDAVTEQELQDMWLEIEK--------EQEARRIEEMKLENRMREREQRKKDLASN-----WRNS- 192
                    |.::::...|        |..::.|:.||::.:::..|....:|.:.     :.|:
Mouse    68 --------LCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAK 124

  Fly   193 -----------------SLAVKRSNQAADTTSVDMDVEDINTSGNGKQQT---GPSP-----LLT 232
                             .|.::..|:...  ..:.|.||.:..|...|.|   |.||     :|.
Mouse   125 AYYKPDSPEYKAACKLWDLYLRTRNEFVQ--KGEADDEDDDEDGQDNQGTLADGSSPGYLKEILE 187

  Fly   233 SLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPT---ITSLLTSGPSSAVANQPVITMKSPTD 294
            .||:                       ::..||.|:   |:.|....||..........:|.|.|
Mouse   188 QLLE-----------------------AIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPID 229

  Fly   295 AAFMSRPI-TGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQG 358
            ...:::.| .|...|..:....::            ||.||  |...||.||
Mouse   230 LKTIAQRIQNGSYKSIHAMAKDID------------LLAKN--AKTYNEPGS------------- 267

  Fly   359 VDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKN------VDDVVA 417
                                     :|||:.:.|.....:..|.:...|:.|:      ..::.|
Mouse   268 -------------------------QVFKDANSIKKIFYMKKAEIEHHEMTKSSLRIRTASNLAA 307

  Fly   418 S----PSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESK 478
            :    ||::|:.:  .|::....|..::|.:....:..::.:.:....:|.::..|||...:|
Mouse   308 ARLTGPSHNKSSL--GEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEE-- 368

  Fly   479 DRGQSGGESTRGTEDAESEPLTSEVAV----EEIGETITIISTSSEDTAGSP----PTKMEEDGA 535
                  |||       |:|.:||.:.|    .::.:|:.............|    |:|
Mouse   369 ------GES-------EAESITSFMDVSNPFHQLYDTVRSCRNHQGQLIAEPFFHLPSK------ 414

  Fly   536 TDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTT 600
                .|..|..:......|..|.:.|.  ...|.|.:||
Mouse   415 ----KKYPDYYQQIKMPISLQQIRTKL--KNQEYETLDH-------------------------- 447

  Fly   601 TQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKL--ALDDSKSELELSGTPQPPSAP 663
                 :..||       :.:.:::|..:.|.||..| ..|||  .:...|.||
Mouse   448 -----LECDL-------NLMFENAKRYNVPNSAIYK-RVLKLQQVMQAKKKEL------------ 487

  Fly   664 ARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDRRET 728
            ||         ||..|    |.|:..:|..|...|.:|:.::.   ||   ..........::..
Mouse   488 AR---------RDDIE----DGDSMISSATSDTGSAKRKRNTH---DS---EMLGLRRLSSKKNI 533

  Fly   729 RAASKKLFLSIY---------AMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSG 784
            |....|:..::.         ..|.|.....|.|:.:.|     :..:.|.|||...|:.||.:.
Mouse   534 RKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPD-----YYKIILEPMDLKIIEHNIRND 593

  Fly   785 FIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARL---FVQDCQAIKEFSQLPDVQAGITATPVS 846
            .......:..|:.||..|.....:..:..:..|.:   .::|.:  ||...|||...  .|:|
Mouse   594 KYAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKR--KELGPLPDDDD--MASP-- 652

  Fly   847 NTGSLRADKSSG 858
               .|:..:.||
Mouse   653 ---KLKLSRKSG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	16/90 (18%)
		PHA03249	402..>582	CDD:223023	35/197 (18%)
		Bromo_brd8_like	729..833	CDD:99939	22/115 (19%)
Pbrm1	NP_001074720.1	Bromo_polybromo_I	44..156	CDD:99954	16/122 (13%)
		Bromo_polybromo_II	182..284	CDD:99948	29/176 (16%)
		Bromo_polybromo_III	383..484	CDD:99951	23/151 (15%)
		Bromo_polybromo_IV	534..637	CDD:99949	20/107 (19%)
		Bromo_polybromo_V	673..777	CDD:99946
		Bromo_polybromo_VI	790..897	CDD:99956
		BAH_polybromo	972..1089	CDD:240068
		BAH_polybromo	1170..1288	CDD:240068
		HMG-box	1395..1459	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900