DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and brd4

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001104751.1	Gene:	brd4 / 570531	ZFINID:	ZDB-GENE-030131-267	Length:	1444	Species:	Danio rerio

Alignment Length:	887	Identity:	168/887 - (18%)
Similarity:	293/887 - (33%)	Gaps:	265/887 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SSPATVETPTELLLRRLTEERQAEIKAQMRQDQ---------ETYRRIQREIESLQSDAVTEQEL 150
            ::|..::||..:..:|.:::|:|:.......||         ::.:.:.|. ::.:...:.::|.
Zfish   279 AAPPILQTPISIPNKRKSQKRKADTTTPTANDQLNESSPAESKSGKTLPRR-DNTRPSKLPKKEA 342

  Fly   151 QDM---WLEI-----EKEQEARR-----IEEM--------------------------------- 169
            .|.   |...     .|:||..|     :::|
Zfish   343 PDSQHHWTAAPGTPSPKQQEQLRYCSGIVKDMFAKKHAAYAWPFYKPVDVDTLGLHDYHDIIKHP 407

  Fly   170 --------KLENRM-REREQRKKDLASNWRNSSLAVKRSNQAADTTSVDMDVEDINTSGNGKQQT 225
                    |||.|. ||.::...|:...:.|   ..|.:....:..::...::|:......|...
Zfish   408 MDLSTIKDKLETRQYREAQEFAADVRLMFSN---CYKYNPPDHEVVAMARKLQDVFEMRFAKMPD 469

  Fly   226 GPSPLLTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMK 290
            .|..:|          ||| |.|                       :|...|   |..|||:...
Zfish   470 EPEEML----------APA-PAP-----------------------VLHPAP---VKTQPVMATA 497

  Fly   291 SPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMA-----AAKANESGSLVKPE 350
            |.:|.:..|     ...||:||    :.|..:.|..|:.|.|:..|     ||.:....|..|.:
Zfish   498 SSSDTSSDS-----SSESESST----DDSEEERAQRLAELQEQLKAVHEQLAALSQPQASKPKKK 553

  Fly   351 GSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDV 415
            ....:|:..|:....|.                 |...:::|::    ...::......||.|.:
Zfish   554 EKEKKEKKKDKHKKKAG-----------------VMPALEEILE----PPPALKPQGKPKNKDPL 597

  Fly   416 VASPSNDKAEVIDFEDKLDALKREQSKS----SPASDKPKSVELVIGSSDDSNDNIPLAAVASQE 476
               |...|        ||.  |:|..||    :|....|.:::.|.|.  |:.:::.|...|:.
Zfish   598 ---PKKSK--------KLS--KKEGGKSNRSMAPPGAAPPTLQPVPGL--DTEEDLGLTGGAAM- 646

  Fly   477 SKDRGQSGGESTRGTEDAESEPLT---SEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGAT-- 536
               .|.:.||..:.....|...|:   :::..:::|..:.||.:.......|.|.::|.|..|
Zfish   647 ---AGMAAGEKCKPMSYEEKRQLSLDINKLPGDKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK 708

  Fly   537 ------------DSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSG---- 585
                        ..|.||:..|..:...|:.|..:.| |.|:|.....:..::....|::|
Zfish   709 PSTLRELERYVSSCLRKKKKPAVPEKSMEAISAVKTK-GTSSDSGSSSESSSSESEDSETGMASK 772

  Fly   586 --KDTAGKPVTMQEKTTTQSAPVP-VDLH-DTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDD 646
              |...|:......:||....|:| |.|. .|.....|:....:...||..|...||.: .||:.
Zfish   773 PKKRGRGEGKKAHHQTTAPGMPLPQVPLQPQTPALQPSIQLKQQQPQHPSPAAYMPPPV-TALEP 836

  Fly   647 SKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCS--STPVI 709
            |    :|...|..|.|.     ...|||.       .:|.::.|..|..|.......|  :.|.:
Zfish   837 S----QLLENPFDPLAH-----FMHLPHH-------ANDSSSPAPPHLNAHPPGGPVSPETHPFL 885

  Fly   710 DSIPNSPASSEHT-----DDRRETRAA-----------------SKKLFLSIYAMLLDSKHAAPF 752
            :..|..|:.:.|.     ..|...|||                 .::..:....:....:..||.
Zfish   886 NQHPILPSPALHNALPQQPSRPSNRAAPLPPKPLQQSTSQQQPPPQQTLVPPQQLQPQQQQPAPP 950

  Fly   753 KR---PFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSE---LHRDVLLMAHNVLVAYKPHT 811
            ::   |.|..||.:  .:..||:..||:   ...|.:.|...   |..|...:....|..|..|.
Zfish   951 QQQHLPHHPLHAPQ--QMRPRPLSPPTL---TPQGLLSSQPPQMLLEDDEEPVPSKSLPMYLQHL 1010

  Fly   812 AQHKTARLFVQDCQAIKEFSQLPDVQAGITATPVSNTGSLRA 853
            ..|:                        :.|||.|...||::
Zfish  1011 QPHR------------------------LQATPTSLMQSLQS 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	21/146 (14%)
		PHA03249	402..>582	CDD:223023	41/200 (21%)
		Bromo_brd8_like	729..833	CDD:99939	21/126 (17%)
brd4	NP_001104751.1	bromodomain 1; BD1	40..152
		Bromo_Brdt_I_like	43..149	CDD:99929
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..217
		bromodomain 2; BD2	356..473		17/119 (14%)
		Bromo_Brdt_II_like	363..464	CDD:99930	12/103 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..523		10/39 (26%)
		NPS region. /evidence=ECO:0000250	498..517		7/27 (26%)
		BID region. /evidence=ECO:0000250	538..610		18/105 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..645		26/140 (19%)
		ET domain	654..729		13/74 (18%)
		BET	657..721	CDD:293640	10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1020..1422		3/9 (33%)
		C-terminal (CTD) region. /evidence=ECO:0000250	1126..1444
		BRD4_CDT	<1419..1444	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810