DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and ep300b

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_009297682.1	Gene:	ep300b / 565612	ZFINID:	ZDB-GENE-080403-15	Length:	2646	Species:	Danio rerio

Alignment Length:	889	Identity:	159/889 - (17%)
Similarity:	275/889 - (30%)	Gaps:	318/889 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RTLKTICG------NGSSNRPADWFSQKNCAMQYGNLLESVEATKRKKRSSESSAGVSSPATVET 102
            |:|..:.|      ||....|   .|.::..|....:|.. ..|.:...:..|..|....|...|
Zfish   469 RSLNNMAGGNSMGVNGGVGAP---MSNQHPGMLPDGMLHR-NMTAQSLMNDSSGVGNMGSAATAT 529

  Fly   103 PTELLLRR-----LTEERQ-----------------AEIKAQMRQDQETY-RRIQREI-ESLQSD 143
            |....:|:     :|::.:                 |.:|.:..::...| |:::.:: ||..|.
Zfish   530 PPSAGMRKSWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSR 594

  Fly   144 AVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKD--LASNWRNSSLAVKRSNQAADTT 206
            |.....|.:...:|:||.|.:|      ..|:::::....|  |......|.:..:..|.|....
Zfish   595 AEYYHLLAEKIYKIQKELEEKR------RTRLQKQDGPHSDPSLVQATGPSQMVNRMQNPAGMPH 653

  Fly   207 SVDMDVEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTPGGA---APAAGGTGSVARATAPT 268
            |:           ||..|.|...     ::.|.|.....|.|.||   ..:..||..:|:...|.
Zfish   654 SL-----------NGMNQFGQVG-----MQQPMGQRATPPLPMGANLNQMSMQGTPRMAQPNVPQ 702

  Fly   269 ITSL------------LTSG-------------PSSAVANQPVITMKSPTDAAFMSRPITG---- 304
            :.:.            |..|             |.:.:...|.:::.||...:..|.|::|
Zfish   703 LQNQYMQNQFTGTGAGLGQGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAG 767

  Fly   305 ---------PPASE----ASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQE 356
                     |||.:    ....|..:.|||.|         :::....|...   ..|:..|||.
Zfish   768 PQGPPSNHPPPAPQPGLHTHCPPLRQNSPSPA---------RSLTPTPAPHQ---TPPQLPGNQT 820

  Fly   357 QGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSN 421
            .......||.
Zfish   821 PQPHTPNSST------------------------------------------------------- 830

  Fly   422 DKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGE 486
                               :.:.|||..|...:.|  :|:.|:.       ..|:|...|.:||.
Zfish   831 -------------------TMAPPASQLPPMAQGV--ASEKSSQ-------LQQQSHGGGATGGP 867

  Fly   487 STRGTEDAESE-----------PLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLP 540
            .|.......|:           ||:.:.:....|:..|..|.||.|    |.:::.....|..|.
Zfish   868 QTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSAD----PSSQLTSSEPTAPLD 928

  Fly   541 KKEDAAEDKSEQESSSQGQNKAGG----------STDEPELIDHQATREAQSKSGKDTAGKPVTM 595
            .|.:..:...|:|:.::.::||.|          |.::||:       :.:..:|.:...:|:
Zfish   929 SKTEVKQQDEEEENENETEDKASGKMAAMQTEIKSEEKPEI-------KKEEPAGDECKTEPM-- 984

  Fly   596 QEKTTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPP 660
              :|:|.....|....:..||..:..:|:..:...:..:.||..|:.||   ...||......|.
Zfish   985 --ETSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKPDELRQAL---MPTLEALYRQDPE 1044

  Fly   661 SAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDR 725
            |.|.|.|               ||                      |.:..||....:|..|:
Zfish  1045 SLPFRQP---------------VD----------------------PQLLGIPVRIRTSNKTN-- 1070

  Fly   726 RETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLS 790
                              ||                  :.|:...|:|..||||.:|:|..:...
Zfish  1071 ------------------LD------------------YFDIVKNPIDLSTIKRKLDTGQYQEPW 1099

  Fly   791 ELHRDVLLMAHNVLVAYKPHTAQ-----HKTARLFVQDCQAIKE 829
            :...||.||.:|..: |...|::     .|.|.:|.|:...:.:
Zfish  1100 QYVDDVWLMFNNAWL-YNRKTSRVYKYCSKLAEVFEQEIDPVMQ 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	19/108 (18%)
		PHA03249	402..>582	CDD:223023	34/200 (17%)
		Bromo_brd8_like	729..833	CDD:99939	22/106 (21%)
ep300b	XP_009297682.1	zf-TAZ	318..385	CDD:280324
		KIX	534..614	CDD:280354	14/79 (18%)
		Bromo_cbp_like	1024..1142	CDD:99927	40/196 (20%)
		RING_CBP-p300	1154..1236	CDD:276805
		PHD_SF	1237..1271	CDD:304600
		HAT_KAT11	1300..1607	CDD:285432
		ZZ_CBP	1663..1703	CDD:239077
		ZnF_TAZ	1724..1802	CDD:214717
		Creb_binding	<2164..2231	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900