DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brd8 and pbrm1

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_009304062.1	Gene:	pbrm1 / 565366	ZFINID:	ZDB-GENE-080926-4	Length:	1627	Species:	Danio rerio

Alignment Length:	616	Identity:	120/616 - (19%)
Similarity:	208/616 - (33%)	Gaps:	186/616 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 TLERSPSQAAPTLSMLLEKNMAAAKANESGSLVK------------PEGSGNQEQGVDEATSSAA 367
            |.|.|.|.....|.|||:   |.....|.|.|:.            |:.....::.:|  ..|.|
Zfish   175 TEEESMSSLKEVLGMLLD---AVLTYTEHGRLISELFQRLPSKMQYPDYYAIIKEPID--LKSIA 234

  Fly   368 GTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFED- 431
                      :..|:. .:|:::.:..|||:         ::||     |...|:....: |:|
Zfish   235 ----------HRIQMC-YYKSVNHMAKDIDL---------LVKN-----AKTYNEPGSQV-FKDA 273

  Fly   432 ----KLDALKR---EQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTR 489
                |:.|.|:   |.|:....|.:.::.....|      |.:.....|.|             .
Zfish   274 NTIKKVFAQKKLELEHSEPIKCSIRIRNRRFAHG------DRLSCITTALQ-------------Y 319

  Fly   490 GTEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEE--DGATDS-----------LPK 541
            |:|..|...||..|..:|:......|.:|.:  ..:|..:|.|  .|..:|           ||.
Zfish   320 GSESEEDAILTGSVHYDEVESEAESIHSSMD--VSNPIFQMYEAVRGVRNSQGQLLAEPFFQLPS 382

  Fly   542 KED-------AAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPV------ 593
            ::|       .:...|.|:..|:.:|....|.::   ||....|..::....:.....:
Zfish   383 RKDYPDYFQQISHPVSLQQIRSKMKNNEYESVEQ---IDTDLNRMFENAKRYNVPSSQIYKRVLK 444

  Fly   594 -----TMQEKTTTQSAPVPVDLHDTDEE-SSSLTD--SSKHDDHPRSAKA-KPPALKLALDDSKS 649
                 .|:.|..|:.     |..|.|.. ||:|:|  |:|...|.::.|. :..||..|:.:::.
Zfish   445 LQHILQMKRKELTRR-----DDEDGDSRLSSTLSDGGSTKRKSHKKNTKKNRMKALLAAVAETRE 504

  Fly   650 ELELSGT-----------PQPPSAP-----ARTPL-LRKLPHRDRS-----ESPMVDD------- 685
                .||           |.....|     ...|: :|.:.|..||     |..|::|
Zfish   505 ----MGTGRRLCDLFMVKPSKKDYPDYYKIILEPMDMRIIEHNIRSDKYPNEDSMMEDMKLMFRN 565

  Fly   686 -------------DATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDRRETRAASKKLFL 737
                         ||...  ....|..|:.....|..|.|     .|.....|:...:..|..:|
Zfish   566 ARHYNEEGSRVYNDANIL--EKILREKRKELGPPPDDDEI-----VSPKLKIRKSGISPKKSKYL 623

  Fly   738 SIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLR----------------PMDFPTIKRNIDSGFI 786
            :.....|:..:.|  .:.:.|:..:|.:.:.||                |:|...||.::.:...
Zfish   624 TPLQQKLNELYEA--VKNYTDKRGRRLSTIFLRLPSRAELPDYYVAIKKPIDMEKIKSHMLANKY 686

  Fly   787 RSLSELHRDVLLMAHNVLVAYKPHTAQHKTA 817
            :.:..|..|::||.:|.....:|.:..:|.|
Zfish   687 QDVDALVEDLVLMFNNACTYNEPESLIYKDA 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	41/207 (20%)
		Bromo_brd8_like	729..833	CDD:99939	20/105 (19%)
pbrm1	XP_009304062.1	Bromo_polybromo_I	45..156	CDD:99954
		Bromo_polybromo_II	183..284	CDD:99948	25/131 (19%)
		Bromo_polybromo_III	352..453	CDD:99951	17/103 (17%)
		Bromo_polybromo_IV	488..591	CDD:99949	19/108 (18%)
		Bromo_polybromo_V	626..730	CDD:99946	18/94 (19%)
		Bromo_polybromo_VI	745..850	CDD:99956
		BAH_polybromo	923..1042	CDD:240068
		BAH_polybromo	1120..1238	CDD:240068
		HMG	1341..1408	CDD:197700
		Forkhead_N	1415..1541	CDD:254796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900