DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and baz2ba

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_021332704.1	Gene:	baz2ba / 561095	ZFINID:	ZDB-GENE-070615-37	Length:	2318	Species:	Danio rerio

Alignment Length:	964	Identity:	194/964 - (20%)
Similarity:	324/964 - (33%)	Gaps:	307/964 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ESVEATKRKKRSSESSAGVSSPAT-----------VETPTELLLRRLTEERQAEIKAQMRQDQET 129
            |..|.||:.:|..........|||           :.....|:.|:|.|...|  ...|...|:.
Zfish  1391 EEEEETKKGRRVETCDEDEGDPATSVEELEKQIEKISKQQNLIRRKLFESSHA--LRSMSYGQDR 1453

  Fly   130 YRR---IQRE-----IESLQSDAVTEQELQDMWLEIEKEQEARR-------IEEMK--------- 170
            :||   |..:     ||:|:|....|        |:|||:|..|       .||.|
Zfish  1454 FRRRYWILPQCGGVYIEALESGEGLE--------ELEKERERLRNCPVVQVKEEPKEEVLQHHQH 1510

  Fly   171 ------LENRMREREQRKKDLASNWRNSSLAVKRSNQAADTTSV---DMDVEDINTSGNGKQQTG 226
                  |:..:::.|::..||.......:    ||:...|.|.|   ...:.::..|.:.:.|..
Zfish  1511 EEIQGTLKEEVKQEEEKPMDLDQEPNKEA----RSSPLKDKTDVVATPPQLPELRLSQSPQCQEP 1571

  Fly   227 P-SP-------LLTSLLKSPTGNAPA------------TPTPGGAAPAAGGTGSVARATAPTI-- 269
            | :|       ..|..:...:|::||            :|....|.|.....|..|....|.:
Zfish  1572 PHTPRHAHNGCSATIAMDMTSGSSPAHSPTTSKLTEASSPNAEHAIPPPLQLGIPAHLLQPQLAQ 1636

  Fly   270 TSLLTSG-----------------PSSAVANQPVI-----TMKSPTDAAFMSRPITGPPAS---- 308
            |.||.|.                 |.|...:..:|     ...||...|..:||.:.||.|
Zfish  1637 TQLLASDQLYKVLSERSGHWFSLLPRSPCDDTSLIQPSAHPQSSPKSNATNTRPKSPPPPSTSSP 1701

  Fly   309 -------EASTTPTLERSPSQAAPTLSMLLEKNMAAAKA-----NESGSLVKP------------ 349
                   .||.:|.   :|:.||...::.::....||..     :.||.::.|
Zfish  1702 HHHLLPLSASASPL---NPTAAAGISNLSVQVKPGAALVGLPLYSWSGGVISPNLPLCSSPLHMY 1763

  Fly   350 ---EGSGNQEQGVDEATS---SAAGTADSDEADPNEAQLLEVFKNID-----QIIDDIDIDMASV 403
               |||.:.......:||   |...||:...:.|:.. .|::.:|.|     .|.:|:.:....|
Zfish  1764 PSVEGSASPLLAPSVSTSKSGSPVPTAEKLASAPSPV-ALDLPRNHDLPEPMAIPEDMLLGWWKV 1827

  Fly   404 IDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIP 468
            .|.|.||.:.:.:.|....:.          ||:::..         ||:||::.:.:.:.:
Zfish  1828 TDMEELKALVNSLHSRGIRER----------ALQKQLQ---------KSMELIVQTCNKNRE--- 1870

  Fly   469 LAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVA----VEEIGETITIISTSSEDTAGSPPTK 529
             .||......|.||...| |......|.:.:.:::|    |||:...:|..|...:......|..
Zfish  1871 -VAVMEVSELDEGQVSVE-TLQEWCVEEQAMETDIALLQQVEELERKVTSASLQVKGWTYPEPQS 1933

  Fly   530 MEED---GATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDE------PELIDHQATREAQSKSG 585
            ..||   .....|||....||.: |:.||.:|..:...:..:      .||..|...|..:|..|
Zfish  1934 EREDLVYFEHKPLPKHRPGAESQ-EERSSEKGLIRRPSNPLDIAVMRLAELERHIERRYLRSPLG 1997

  Fly   586 KDTAGKPVTMQEK-----TTTQSAPVPVDLHDTDEESSSLTDSSKHDDHPRSAKAKPPALKL--- 642
                   .|:|.|     |.|..||.|         |:|.......::       ..|.:||
Zfish  1998 -------TTIQIKLDNVGTVTVPAPAP---------STSAGGEGGEEE-------IAPGMKLWRK 2039

  Fly   643 ALDDSKSELELS----------------------------------------------------- 654
            ||.:.:|..:|:
Zfish  2040 ALSEVRSSSQLAMCLQQLQKSIAWEKSIMKVYCQICRKGDNEDLLLLCDGCDKGCHTYCHKPKIT 2104

  Fly   655 ---------------GTPQPPSAPARTPLLRKLP-----------HRDRSESPMVDDDATTASDH 693
                           .:.|.|.:.::|| .|..|           .:.:.::...:::..|:|.:
Zfish  2105 TIPEGDWYCPDCISKASGQSPKSKSKTP-NRTAPASGGKKTAEAAKKSKKQAETGEEEEATSSTN 2168

  Fly   694 STAR-------STRRRCSSTP-VIDSIPNSPASSEHTDDRRETRAASKKLFLS--IYAMLLDSKH 748
            ||.:       ..::..:||| .:...|:|||..:.....|:.   ::.|.|.  :.|.|...:.
Zfish  2169 STPKKATAASSQNKKNSASTPNQMAPKPDSPACVKRAKTARDN---NRDLGLCRILLAELERHQD 2230

  Fly   749 AAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHN 802
            |.||..|.:.:....:..:..:||||.||:..:.|...::|.....||.|:..|
Zfish  2231 AWPFLNPVNLKSVPGYRKVIKKPMDFSTIREKLVSSQYQNLETFIIDVNLVFDN 2284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	28/112 (25%)
		PHA03249	402..>582	CDD:223023	42/192 (22%)
		Bromo_brd8_like	729..833	CDD:99939	20/76 (26%)
baz2ba	XP_021332704.1	HAT_MBD	809..880	CDD:238691
		TPH	952..>1143	CDD:316391
		DDT	1167..1227	CDD:214726
		WSD	1450..>1470	CDD:317927	4/19 (21%)
		WSD	<1824..1856	CDD:317927	8/50 (16%)
		PHD_BAZ2B	2070..2118	CDD:277100	0/47 (0%)
		BAH	2093..>2145	CDD:322012	6/52 (12%)
		ADK	<2119..2209	CDD:331878	17/90 (19%)
		Bromo_BAZ2A_B_like	2214..2310	CDD:99935	20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900