DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brd8 and Crebbp

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_038942595.1	Gene:	Crebbp / 54244	RGDID:	2401	Length:	2454	Species:	Rattus norvegicus

Alignment Length:	651	Identity:	127/651 - (19%)
Similarity:	187/651 - (28%)	Gaps:	298/651 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 INTSGNGKQQTG-------------PSPL-----LTSLLK-SPTGNAPATPTPGGAAPAAGGTGS 260
            :|:.|.|:..|.             |:||     .||.|. .|...:|..|||..|:.|| |..|
  Rat   807 VNSVGMGQPATQAGVSQGQVPGGTLPNPLNMLAPQTSQLPCPPVTQSPLHPTPPPASTAA-GMPS 870

  Fly   261 VARATAPTITSLLTSGPSSAVANQPVITMKSPTDAAFMSRPITG--PPASEASTTPTLERSPSQA 323
            :...|.|.:|.     |..|...||    .:|..:.....|..|  |.|::..:|||::
  Rat   871 LQHPTPPGMTP-----PQPAAPTQP----STPVSSGQTPTPTPGSVPSAAQTQSTPTVQ------ 920

  Fly   324 APTLSMLLEKNMAAAKAN---------ESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNE 379
                        |||:|.         :..|:..|:.|..|...|.   :...||..|..|
  Rat   921 ------------AAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVH---TQPPGTPLSQAA---- 966

  Fly   380 AQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSS 444
                                          .::|:.|.:||:             ....|.|...
  Rat   967 ------------------------------ASIDNRVPTPSS-------------VTSAETSSQQ 988

  Fly   445 PASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEIG 509
            |..|.|                       ..|.|...|        |:|||.:|..|:
  Rat   989 PGPDVP-----------------------MLEMKTEVQ--------TDDAEPDPAESK------- 1015

  Fly   510 ETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDH 574
                          |.|.::|.|:....|...||:.  |.:||:|
  Rat  1016 --------------GEPRSEMMEEDLQGSSQVKEET--DTTEQKS-------------------- 1044

  Fly   575 QATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDS-SKHDDHPRSAKAKPP 638
                            :|:.::||    ...|.|:..:.:|.|::.|.| |.....||....||.
  Rat  1045 ----------------EPMEVEEK----KPEVKVEAKEEEENSANGTASQSTSPSQPRKKIFKPE 1089

  Fly   639 ALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRC 703
            .|:.||   ...||......|.|.|.|.|               ||
  Rat  1090 ELRQAL---MPTLEALYRQDPESLPFRQP---------------VD------------------- 1117

  Fly   704 SSTPVIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLC 768
               |.:..||:                                                 :.|:.
  Rat  1118 ---PQLLGIPD-------------------------------------------------YFDIV 1130

  Fly   769 LRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQ-----HKTARLFVQDCQAIK 828
            ..|||..||||.:|:|..:...:...||.||.:|..: |...|::     .|.|.:|.|:...:.
  Rat  1131 KNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWL-YNRKTSRVYKFCSKLAEVFEQEIDPVM 1194

  Fly   829 E 829
            :
  Rat  1195 Q 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	29/179 (16%)
		Bromo_brd8_like	729..833	CDD:99939	21/106 (20%)
Crebbp	XP_038942595.1	zf-TAZ	362..429	CDD:396624
		KIX	586..666	CDD:366953
		PHA03247	<682..1098	CDD:223021	94/465 (20%)
		COG5076	942..>1194	CDD:227408	87/485 (18%)
		Bromo_cbp_like	1088..1195	CDD:99927	37/196 (19%)
		RING_CBP-p300	1207..1289	CDD:276805
		PHD_CBP_p300	1291..1322	CDD:277032
		HAT_KAT11	1353..1660	CDD:400497
		ZZ_CBP	1716..1756	CDD:239077
		zf-TAZ	1783..1851	CDD:396624
		Med15	1971..>2425	CDD:312941
		Creb_binding	2045..2123	CDD:401102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900