DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Baz2b

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_011237963.1	Gene:	Baz2b / 407823	MGIID:	2442782	Length:	2197	Species:	Mus musculus

Alignment Length:	735	Identity:	147/735 - (20%)
Similarity:	237/735 - (32%)	Gaps:	222/735 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILASAVSCSGDQNWITVS--RTLKTICGNGSSNRPADWFSQKNCAMQYGNLLESVEATKRKKRSS 88
            ::|:..|.|..||..|.|  .|||  |           ..::|.:.......:.::..|.:|::.
Mouse   204 VVATPASSSMGQNQSTSSGGGTLK--C-----------HQEQNKSQPVDARADRIKDKKPRKKAM 255

  Fly    89 ESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAVTEQELQ-- 151
            |||:...|.:...:.|.  ...::.....:::.:..:||..     .|.|...||:.||.:.:
Mouse   256 ESSSNSDSDSGTSSDTS--SEGISSSDSDDLEEEEEEDQSV-----EESEDDDSDSETEAQHKSN 313

  Fly   152 -------------DMWLEIEKEQEARRIEEM----------KLENRMRERE-------------Q 180
                         |.....||.||.|..:.:          ..:::.::.:             |
Mouse   314 NQVLLHGISDPKTDGQKATEKAQERRTHQPLPPVSESQTHPPFQSQQKQPQVLSQQLPFIFQSSQ 378

  Fly   181 RKKD-------------LASNWRNSSLAVKRSNQAADTTSVDMDV--EDINTSGNGKQQTGPSPL 230
            .|::             |.||.:..||.    |||...|...:.|  .|:..:|| |..:..|..
Mouse   379 AKEESVTKHTSVIQSTGLVSNVKPLSLV----NQAKKETYRKLVVPSPDVLKAGN-KNTSEESSS 438

  Fly   231 LTSLLKSPTGNAPATPTPGGAAPAAGGTGSVARATAPTITSLLTSGPSSAVANQPVITMKSPTDA 295
            |||.|:|.......|      .|:.|....:.::....|.:|..:..:|:....|.:.:.:....
Mouse   439 LTSELRSKREQYKQT------FPSQGKKQEMGKSLKKVIAALSNTKATSSSPAHPKLPLDNNHPN 497

  Fly   296 AFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLVKPEGSGNQEQGVD 360
            .|::..:.|...........::.:|       ..|..|....:|.||:.|...|..|     .|:
Mouse   498 PFLTNALLGNHQPNGVIQSVIQEAP-------LALTTKTKMQSKINENVSSSTPFSS-----PVN 550

  Fly   361 EATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVVASPSNDKAE 425
            .:||..........|.|:.:.:|.
Mouse   551 LSTSGRRAPGSQTPALPSASPILH----------------------------------------- 574

  Fly   426 VIDFEDKLDALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRG 490
                                :|.|.|.|         |||..||.|...........:..|..||
Mouse   575 --------------------SSGKEKRV---------SNDATPLKAHHHPHPAAAAAALVEQFRG 610

  Fly   491 TEDAESEPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESS 555
            |:        |:|             .||:|:..|...:.|:|...|....::|.::| |:.||.
Mouse   611 TD--------SDV-------------PSSKDSEDSNEDEEEDDEEEDEEDDEDDESDD-SQSESD 653

  Fly   556 SQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSL 620
            |..|:.:.||.|:.|        :.|.:|..||.|:...:....|:.||..|         .|||
Mouse   654 SNSQSDSEGSEDDEE--------KDQEESDSDTEGEKPAVNLTQTSSSAKSP---------PSSL 701

  Fly   621 TDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPS-APARTPLLRKLPHRDRSESPMVD 684
            |..|....|..|.....||            .|....|||: ....:..|...||...|:...|.
Mouse   702 TAHSAPHLHIGSPPGSAPA------------ALCSESQPPAFLGTSSSTLTSTPHSGTSKRRRVA 754

  Fly   685 DD--ATTASDHSTARSTRRR 702
            ||  .....|:...|.||.|
Mouse   755 DDQELRIPLDYGWQRETRVR 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	17/133 (13%)
		PHA03249	402..>582	CDD:223023	34/179 (19%)
		Bromo_brd8_like	729..833	CDD:99939
Baz2b	XP_011237963.1	MBD	758..827	CDD:412167	5/17 (29%)
		TPH	<835..1052	CDD:404709
		DDT	1079..1142	CDD:214726
		WHIM1	1183..1223	CDD:406127
		WSD	1363..>1395	CDD:406128
		WSD	<1706..1745	CDD:406128
		PHD_BAZ2B	1961..2009	CDD:277100
		Bromo_BAZ2A_B_like	2094..2190	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900