DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and Baz1b

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001178845.1	Gene:	Baz1b / 368002	RGDID:	1597089	Length:	1476	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	150/698 - (21%)
Similarity:	235/698 - (33%)	Gaps:	210/698 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 RPITG-------PPASEASTT-----PTLERSPSQ---AAPTLSMLLEKNMAAAKANESGSLVKP 349
            :|:.|       |...||..|     ..|||...:   ...|.|..|....|..:..|...|:|.
  Rat    14 KPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKE 78

  Fly   350 E---------------GSGNQEQGVDEA-----TSSAAGTADSDEADPNEAQLLEVFKNIDQIID 394
            |               .:.:.|:.||.|     |..|.|    :|.|      .||.|.....:.
  Rat    79 EFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVG----EECD------FEVGKEKMLKVK 133

  Fly   395 DIDIDMASVIDDEIL-KNVDDVVASPSNDK-----------AEVIDFED---------------- 431
            .:.|.....:|:|.. |..|....|||:||           .|.:..||
  Rat   134 IVKIHPLEKVDEEAAEKKSDGTCDSPSSDKENSSQMAQDHQKETVVKEDGGRRESINDRARRSPR 198

  Fly   432 KL-DALKREQSKSSPASDKPKSVELVIGSSDDSNDNIPLAAVASQE---SKD-----------RG 481
            || .:||:.:.|.:|....|...::.:.|.|....|:|..::...|   :|:           |.
  Rat   199 KLPTSLKKGERKWAPPKFLPHKYDVKLQSEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRA 263

  Fly   482 QSGGESTRGTEDAESEPLTSEVAVEEIGETITIISTSSEDTAG-------SPPTKMEEDGATDSL 539
            .:|          |:.|...|   :|:.:..::.|..|:....       :|.||.:..|:.|..
  Rat   264 GTG----------ENAPWVVE---DELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRK 315

  Fly   540 PKKEDAAEDKSEQESSSQGQNKAGGSTDEPELIDHQATREA------QSKSGKDTAGKPVTMQEK 598
            |.|      |.::::||.      .|...|:|..|....::      :.|:.|::......::|.
  Rat   316 PSK------KPKRDNSSL------SSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSKSPEEHLEEV 368

  Fly   599 TTTQSAPVPVDLHD--TDEESSSLTDSSKHDDHPRSAKAKPPALKLALDDSKSELELSGTPQPPS 661
            ....|   |..||.  ..::..|.....||.|.|..||.:...:   |:..||    :|..:.||
  Rat   369 MKIMS---PNKLHSFHIPKKGPSTKKPGKHSDKPLKAKGRGKGI---LNGQKS----TGNSKSPS 423

  Fly   662 APARTP--LLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNS--------- 715
            ...:||  .::::...|.::              .|.:.||...||    ..:|.|
  Rat   424 KCVKTPKTKMKQMTLLDMAK--------------GTQKMTRTPRSS----GGVPRSSGKPHKHLP 470

  Fly   716 PAS-------SEHTDDRRETRAASKKLFLSIYAMLLDSKHAAPF---------KRPFHDEHAQRH 764
            ||:       .|:.|  :|.:.::....:|..|.||.|:..|..         ||....||.:|.
  Rat   471 PAALHLIAYYKENKD--KEDKKSALSCVISKTARLLSSEDRARLPEELRALVQKRYELLEHKKRW 533

  Fly   765 ADLC--------------LRPMDFPTIKRNIDSGFIRSLSELHR--DVLLMAHNVLVAYKPHTAQ 813
            |.:.              |:.......|...:...:..|.:..|  |..|...|:.......|.:
  Rat   534 ASMSEEQRKEYLKKKRQELKERLREKAKERREKEMLERLEKQKRYEDQELGGRNLPTFRLVDTPE 598

  Fly   814 HKTARLFVQDCQAIKEFSQ------LPDVQAGITATPVSNTGSLRADK 855
            .....|| .|...:.||..      |||.|..|||  ||...:|.|||
  Rat   599 GLPNTLF-GDVALVVEFLSCYSGLLLPDAQYPITA--VSLMEALSADK 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	47/235 (20%)
		Bromo_brd8_like	729..833	CDD:99939	25/134 (19%)
Baz1b	NP_001178845.1	WAC_Acf1_DNA_bd	21..120	CDD:287503	22/102 (22%)
		DDT	602..666	CDD:214726	18/45 (40%)
		WHIM1	722..771	CDD:292246
		WHIM2	897..925	CDD:292247
		WHIM3	988..1026	CDD:292248
		PHD_BAZ1B	1183..1228	CDD:277098
		Bromo_WSTF_like	1337..1433	CDD:99937
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900