DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and tou

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	137/829 - (16%)
Similarity:	260/829 - (31%)	Gaps:	267/829 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 AMQYGNLLESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRR 132
            ||:....|:..|..:.|:::.:...  |.........||..::..|||:...:...|..||...:
  Fly  1076 AMRDAKKLQKEELARNKEKARQEKN--SKLEQQRKDKELKNQQAVEERKKRQEELDRLKQEELLK 1138

  Fly   133 IQREIESLQSDAV--TEQELQ---DMWLEIEKEQEARR-----IEEMKLENRMREREQRKKDL-- 185
            .|:|.|..:.:|:  .|||||   :|.|..|.|:|.||     |..::|..:..:||::|..|
  Fly  1139 KQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFEDREKKKHQLVL 1203

  Fly   186 ----------ASNWRNSSL--AVKRSNQAA----------------------------------- 203
                      |...|::.:  .::|.|:.:
  Fly  1204 DRLLLRERRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLH 1268

  Fly   204 ---DTTSVDMD------------VEDINTSGNGKQQTGPSPLLTSLLKSPTGNAPATPTPGGAAP 253
               :|...||:            :.|.|.....:..:..:.||...::.     |..|.||....
  Fly  1269 NFGETLGFDMESLPSLQNLHDALMSDSNADAEEELLSVMTHLLVCAIED-----PGVPNPGRHTT 1328

  Fly   254 AAGGTGSVARATAPTITSLL-------------------------------------TSGPSSAV 281
            ..|.:...|..|...::.:|                                     |:..|.:|
  Fly  1329 LLGQSLRNADITNSNVSEILRIYLYATATGEVRQMHGITVDRERERRVPDHHQLDSDTTTHSHSV 1393

  Fly   282 ANQPVITMKSPTDAAFMSRPITGPPASEASTTPT------------------------------- 315
            .||....:....|...:|:.:...|.  .:..||
  Fly  1394 KNQEYYKLLHENDTWKLSQSLKDRPF--VALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCA 1456

  Fly   316 ----------------------------LERSPSQAAPTLSMLL------------EKNMAAAKA 340
                                        .||:.::....:..|:            |:...||.|
  Fly  1457 QMRKEKYMTDMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAA 1521

  Fly   341 NESGSLVKPEG--------SGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFKNIDQIIDDID 397
            .|:.:....:|        :|.:.:..|:....||......:..|.|         :|.::|:..
  Fly  1522 EEAAAAAGTDGEATKGGSPNGEKPEDGDQNEEGAAKEPQQQQQQPME---------VDGVVDEAS 1577

  Fly   398 -IDMASVI---DDEILKNVDDV---------VASPSNDKAEVIDFEDKLDALKREQSKSSPASDK 449
             :..|..|   |:.:..:..|:         .::|:.......|....|.| |:..:::|...:.
  Fly  1578 LVSPAKTIIQTDNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQA-KKSGARNSINDEH 1641

  Fly   450 PKSVELVIGSSDDSNDNIPLAAVASQESKDRGQSGGESTRGTEDAESEPLTSEVAVEEI------ 508
            ...|.::    ||...::.......:|.:|...|..|..:..:......|..:.|:|:.
  Fly  1642 HHDVSII----DDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRA 1702

  Fly   509 -------------------GETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQES 554
                               |..|..:.::..|..       :...|.:::..|:||.::|   |:
  Fly  1703 ACFGQDRFWRRYWKLPKAGGIFIEALESAQNDIC-------DYHEALEAMDDKKDANDEK---EN 1757

  Fly   555 SSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSS 619
            |...::.|..|:::|..:|...|:........| .|.|.:.|:...........|:.:.::....
  Fly  1758 SENEKDVAAESSEQPMEVDESITKLEDGVPASD-VGMPESNQQNAHQDEEDDDDDVTEINKVEPE 1821

  Fly   620 LTDSSKHDDH--PRSAKAKPPALKLALDDSKSELELSGTPQPPSAPART 666
            :.|....||.  |...|.:||..::.:   |||:||.|.|.......:|
  Fly  1822 IVDLGDDDDDAAPPLPKIEPPRPEIKV---KSEMELMGPPPTTMISTKT 1867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	31/104 (30%)
		PHA03249	402..>582	CDD:223023	34/216 (16%)
		Bromo_brd8_like	729..833	CDD:99939
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720	11/52 (21%)
		MAP7	1043..1198	CDD:283355	34/123 (28%)
		RILP-like	1085..>1179	CDD:304877	27/95 (28%)
		DDT	1255..1317	CDD:280886	7/61 (11%)
		WHIM1	1406..1455	CDD:292246	5/50 (10%)
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900