DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brd8 and baz1a

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001352072.1	Gene:	baz1a / 334173	ZFINID:	ZDB-GENE-030131-6105	Length:	1470	Species:	Danio rerio

Alignment Length:	1023	Identity:	200/1023 - (19%)
Similarity:	344/1023 - (33%)	Gaps:	307/1023 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSRMPLDTWSKREQL---ILASAVSCSGDQNWITVSRTLKTICGNGSSNRPADWFSQKNCAMQYG 72
            |.::.||:.:..|.|   ||:|...|    .:.......:...|.||::.|.......|    :|
Zfish   519 LKQLDLDSCTLSEILRLHILSSGADC----GFTNAKFRYQKQGGFGSTDDPCVELRLSN----HG 575

  Fly    73 NLLESVEATK-------RKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQ-DQET 129
             ||:.:..|.       .|.:...|..|  ...|:.:..:.:.....|:|.|  |.::|: ..|.
Zfish   576 -LLKKLSCTSVYDLLPGEKLKILHSMCG--KLLTLVSTRDFIEDNADEQRAA--KQELRELKAEQ 635

  Fly   130 YRRIQREIESLQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSL 194
            :||                         |:|:.|.|:.:.| |.::||:|.:.|:.....:..:
Zfish   636 HRR-------------------------EREEAAERVRKRK-EEKLREQELKLKEKHERLKEEA- 673

  Fly   195 AVKRSNQAADTTSVDMDVEDINTSGNGKQQT---GPSPLLTSLLKSPTGNAPATPT--------- 247
              |...|.|   ..:||....:..|:.:|.|   ...|..:..:|...|.....|:
Zfish   674 --KNGGQLA---GEEMDTSTESQEGHAEQHTEDEEEQPAKSKKVKKTNGTTKEKPSGEVEMKDNL 733

  Fly   248 -----------------------------PGG---------AAPAAGGTGSVARATAPTITSLLT 274
                                         |.|         ..|:||.. .|..........:|.
Zfish   734 SPEELQLQQLKERELLERIQQAMACTYILPLGRDRLYRRYWIFPSAGAL-FVEDDFFGLTEDMLE 797

  Fly   275 SGPSSAVANQPVITMKSP--TDAAFMSRPI---TGPPASEA------STTPTLER-----SP--- 320
            ..|:.....:.|::.:||  ||.|.....:   |.||.:..      |||..:|:     :|
Zfish   798 PRPTPEPKIEEVLSAESPVKTDGATEELVLVQNTSPPVNRPNQWYFYSTTEEVEQLIEALNPRGL 862

  Fly   321 --SQAAPTLSM-------LLEKNMAAAKANESG-SLVKPEGSGNQEQGVDEATSSAAGTADSDEA 375
              |....||::       |:|.| ||.:.:.|| ||.:.:||..:.:...::|..|
Zfish   863 RESSLKETLTLERGRIFQLMESN-AAQRYHHSGESLPETKGSSGKAKVGPQSTVPA--------- 917

  Fly   376 DPNEAQLLEVFKNIDQIIDDIDIDMASVIDDEILKNVDDVV---------ASPSNDKAEVID--- 428
                    |.|  ::..:.|:.:|    |:|.|.:.....:         |:..|...|::|
Zfish   918 --------ECF--MENRLRDLLLD----IEDRIYQGTLGSIKVMERNSWRAALENGNYELLDPDF 968

  Fly   429 --------------------FEDKLDALKRE-QSKSSPASDKPKSVELVI--------------- 457
                                .:|:|..||.| .|.:|.:...|:.|..|:
Zfish   969 KEYGLTDREEEPMEIEENHRVKDRLQELKVEGHSATSTSVSTPQPVNNVVHCLAHALAQVEQGIE 1033

  Fly   458 --------GSSDDSNDNIPLAAVASQESKDRGQS-----GGESTRGTEDAESEPLTSEVAVEEIG 509
                    |..|...|.   .|....:.||..||     |.||.|..:..:.....|.:|...:.
Zfish  1034 RKFLKAPLGDEDAKKDQ---KAKKKDKKKDDDQSSEKDDGSESGRQVKTVQERWRESLLACTSLS 1095

  Fly   510 ETITIISTSSEDTAGSPP---TKMEEDGATDSLPKKEDAAEDKSEQESSSQGQN--------KAG 563
            :....:||.....|.:..   |:.:       :.:::..||:....:...:|.:        ||.
Zfish  1096 QVFLHLSTLERSVAWAKSILNTRCK-------VCRRKGDAENMLLCDGCGRGYHIFCVRPKLKAV 1153

  Fly   564 GSTDE--PELIDHQATREAQSKSGKDTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSLTDSSKH 626
            .|.|.  ||....|......|:....     |..:|:...:......|..:::||..|..:.|:.
Zfish  1154 PSEDWFCPECRPKQRLNRINSRQRSS-----VDSEEEMEDEEESEEEDEEESEEEEESEEEQSEE 1213

  Fly   627 DDHPRSAKAKPPALKLALDDSKSELELSGTPQPPSA---------------PAR----------- 665
            ::.|:.|     |:||.|.::|.....|.:.|..||               ||.
Zfish  1214 EEVPKKA-----AVKLPLQNNKGGRSNSKSKQAESANSTSRSQQNTPKQSQPANKGGSKNSGKKA 1273

  Fly   666 TPLLR-KLPHR--DRSESPM-----VDDDATTASDHSTARSTRRRCSSTPVIDSI---------P 713
            ||:.. |.|.|  :||.:.:     ..:|.|..|:.|:..:........|:...:         |
Zfish  1274 TPVSNGKPPSRAGNRSSARLSLEVISTNDTTGKSEQSSPAAGNAESRKRPITAEVSPKSKIILAP 1338

  Fly   714 NSPASSEHTDDR----RETRAASKKLFLSIYAMLLDSKHAAPFKRPFHDEHAQRHADLCLRPMDF 774
            .:.:||..:..|    .|..|..   .||:  .|:..:.:.||.:.........:.|:..:|:..
Zfish  1339 TTTSSSRRSSGRNLGVHELSACE---LLSV--DLVRHEDSWPFMKLVSRTQVPDYYDIIKKPIAL 1398

  Fly   775 PTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQ 822
            .||:..:::...::.:|...||.||..|.| .|.||......|.|.:|
Zfish  1399 STIREKVNNCEYQTAAEYIEDVELMFSNCL-EYNPHNTNEAKAGLRLQ 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	18/83 (22%)
		PHA03249	402..>582	CDD:223023	45/253 (18%)
		Bromo_brd8_like	729..833	CDD:99939	23/94 (24%)
baz1a	NP_001352072.1	WAC_Acf1_DNA_bd	23..122	CDD:313708
		DDT	406..467	CDD:214726
		WHIM1	570..615	CDD:317926	9/51 (18%)
		Neuromodulin_N	<618..747	CDD:331332	30/162 (19%)
		WSD	759..875	CDD:317927	25/116 (22%)
		PHD_BAZ1A	1118..1163	CDD:277097	8/51 (16%)
		Bromodomain	1353..1457	CDD:321986	24/99 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900