DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and bptf

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_009297692.1	Gene:	bptf / 324479	ZFINID:	ZDB-GENE-030131-3200	Length:	2900	Species:	Danio rerio

Alignment Length:	927	Identity:	154/927 - (16%)
Similarity:	292/927 - (31%)	Gaps:	267/927 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIESLQSDAV 145
            |:::.::|..:..|.:|..:.||.:    ..|.:..|..:.|..|.:.|..::.:..:..|..
Zfish  2098 TQQQVQTSSGTQVVGTPPRLPTPNQ----PQTPQTPASPRPQQGQVKLTLAQLTQLTQGAQGG-- 2156

  Fly   146 TEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLAVKRSNQAADTTSVDM 210
                                                         |..|.|....|...|..:.:
Zfish  2157 ---------------------------------------------NQGLTVVIQGQGQTTGQLQV 2176

  Fly   211 DVEDINT-SGNGK---QQTGPSPLLTSLLKSPTGNAPATPTP----GGAAPAAGGTGSVARATAP 267
            ..:.:.. .|.|:   |...|:..:...|.:|...|| ||.|    ..|||:.....||..|.||
Zfish  2177 IPQGVTVIPGPGQQLMQAAMPNGQVQRFLFTPMAPAP-TPAPAPVSAPAAPSNTTPSSVPPAAAP 2240

  Fly   268 TITSLLTSGPSSAVAN-----QPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTL 327
            |..:..|..|....|.     ||..::..|.... .|:|:...||...:........|.|..|.:
Zfish  2241 TAVTSTTPAPIQTAARLAPQPQPPPSLPPPPSVP-PSQPVQHTPAPIQTAVIPQPTPPIQPHPPV 2304

  Fly   328 SMLLEKNMAAAKANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNEAQLLEVFK-NIDQ 391
            .:..:..:.     ....:|.|......:  :.:.|::         |.|.:...|.|.: .:.:
Zfish  2305 QLRPQPQLP-----PQNPVVPPTPVSTPQ--IAQVTAT---------APPQQITTLPVTQTTVTK 2353

  Fly   392 IIDDIDI--DMASV--IDDEILKNVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPASDKPKS 452
            :...|.:  .:.||  :..::|.::...||      |::             |::....:..|:.
Zfish  2354 VQPQIQLPPQLLSVPGLQQQVLSHIQSQVA------AQI-------------QAQVGTTAGMPQQ 2399

  Fly   453 VELVI--------GSSDDSND-----NIPLAAVASQ--------ESKDRGQSGGESTRGTEDAES 496
            ::|.:        |....::.     .|..|:|..|        |.:.:.:...|:.|  |.|:.
Zfish  2400 IKLQLPIQIQQQGGGQVQAHQIQNLVTIQTASVQEQLQRIQQLCEQQQQKKKQQEAKR--EQAQQ 2462

  Fly   497 EPLTSEVAVEEIGETITIISTSSEDTAGSPPTKMEEDG-----------ATDSLPKKE-DAAEDK 549
            ....|::..:::.:...:.....:......|.:.||:.           ..|.:.|.| .||:.:
Zfish  2463 HVSQSDLIQKQVAQKQNVAIEQLKQKKTMTPAEREENQRMIVCNQVMKFILDKIDKDERQAAKKR 2527

  Fly   550 SEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKDTAGKPVTMQ--------------EKTT 600
            ..:||..|.::|...|.....|..|:...:|.....:....|.:.:|              ||..
Zfish  2528 KREESVEQKRSKQNASKLSALLFKHKEQLKADILKKRALLDKELQLQVQEELKRDLIKLRREKEK 2592

  Fly   601 TQ------------SAPVPVDLHD-----TDEESSSLTDSSKHDDHPRSAKAKPPALKL---ALD 645
            .|            :|.....:|.     |...:|..:...:..:..|.| |||...|:   ...
Zfish  2593 AQAAAAQAAAAAAAAAAASTHVHSGLSSYTGTVTSPTSTHKRKREEERDA-AKPKRKKMISTTSK 2656

  Fly   646 DSKSELELSGTPQPPSAPARTPLLRKLPHRDRSE----------------SPMVDDDATTASDHS 694
            |||.:::|.             .:.|.|: |.|:                ..:.:.:|....|:.
Zfish  2657 DSKRDIKLY-------------CICKTPY-DESKFYIGCDLCSNWYHGECVGITEKEAKKMDDYI 2707

  Fly   695 TARSTRRRCSSTPVIDSIPNSP--------------------------ASSEHTDDRRETRAASK 733
            .:...|.:..:|..:..|..:|                          :.:.|.|:....:..|.
Zfish  2708 CSECKRAQEGNTEELYCICRTPYDESQFYIGCDRCQNWYHGRCVGILQSEATHIDEYVCPQCQST 2772

  Fly   734 KLFLSIYAMLLDS---------------KHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDS 783
            :..:::...|.|.               |.|.||..|.....|..:..:...|||..|::..|..
Zfish  2773 EDAMTVLTPLTDKDYEGLKRILRSLQSHKMAWPFLEPVDPNDAPDYYGIIKEPMDLSTMEERIQK 2837

  Fly   784 GFIRSLSELHRDVLLMAHNVLVAYKPHTAQHKTARLFVQDCQAIKEFSQLPDVQAGITATPVSNT 848
            .|...|:|...|:..:..|... |.|..:.      |.|..:.::.|.             |...
Zfish  2838 RFYSKLTEFVADMTKIFDNCRY-YNPSDSP------FYQCAEFLESFF-------------VQKL 2882

  Fly   849 GSLRADKSSGSKARSGS 865
            .:.:|.:|..:|.:|.:
Zfish  2883 KAFKASRSHNNKLQSSA 2899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	6/82 (7%)
		PHA03249	402..>582	CDD:223023	36/214 (17%)
		Bromo_brd8_like	729..833	CDD:99939	24/118 (20%)
bptf	XP_009297692.1	DDT	198..254	CDD:280886
		WHIM1	296..345	CDD:292246
		PHD1_BPTF	349..391	CDD:277034
		WHIM2	414..439	CDD:292247
		PP28	<1833..1881	CDD:287254
		PHD2_3_BPTF	2665..2711	CDD:277035	6/59 (10%)
		PHD2_3_BPTF	2723..2769	CDD:277035	4/45 (9%)
		Bromo_gcn5_like	2785..2885	CDD:99941	22/119 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900