DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brd8 and fs(1)h

DIOPT Version :9

Sequence 1:	NP_651685.2	Gene:	Brd8 / 43460	FlyBaseID:	FBgn0039654	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster

Alignment Length:	789	Identity:	143/789 - (18%)
Similarity:	246/789 - (31%)	Gaps:	222/789 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LESVEATKRKKRSSESSAGVSSPATVETPTELLLRRLTEERQAEIKAQMRQDQETYRRIQREIES 139
            |||..|:..:|::.:..:|.|.                :|:.||.|      ||..:|:|.....
  Fly  1009 LESYVASCLRKKTHKKPSGKSK----------------DEQMAEKK------QELEKRLQDVTGQ 1051

  Fly   140 LQSDAVTEQELQDMWLEIEKEQEARRIEEMKLENRMREREQRKKDLASNWRNSSLAV-------- 196
            |.:...|.::.:....::|..|.|..:...  .:..........|.:|:..:.|.||
  Fly  1052 LGASKKTAKKDESASSKVEAVQPANPVSSS--SSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTG 1114

  Fly   197 ------KRSNQAADTTSVDMDVEDINTSGNGKQQTG---PSPLL------------TSLLKSPTG 240
                  .|..::.|:...:::...||....|...:|   |:.:|            ||.:.:..|
  Fly  1115 DGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMSNMLG 1179

  Fly   241 NA-PATPT-----------PG---GAAPAAG-----GTG---SVARATAPTITSLLTSGPSSAVA 282
            || |.|..           ||   |.|||.|     |.|   :.|..:|.|......:||:....
  Fly  1180 NANPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSK 1244

  Fly   283 NQPVITMKSPTDAAFMSRPITGPPASEASTTPTLERSPSQAAPTLSMLLEKNMAAAKANESGSLV 347
            .||    ..|.:||.       ||.|.|..|.|:..|.|.....:               :.:|.
  Fly  1245 VQP----GGPINAAL-------PPHSFAGGTATVATSQSSGGIRI---------------ASNLH 1283

  Fly   348 KPEGSGNQEQGVDEATSSAA--------GTA---------DSDEADP------------NEAQLL 383
            ||.|.|..:.|...|..:||        |||         .::.|:|            :.|.|.
  Fly  1284 KPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLASLA 1348

  Fly   384 EVFKNIDQIIDDIDIDMASV-----------IDDEILKNVDDVVASPS-------NDKAEVIDFE 430
            ...|.|.|..|.::..:||:           :.|..|  :...:..|:       ..:.:....:
  Fly  1349 SGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFL--MQQHLMQPAGPQQQQQQQQQQPFGHQ 1411

  Fly   431 DKLDALKREQSKSSPASD-----KPKSVELVIGSSDDS--NDNIPLAAVASQESKDRGQSGGEST 488
            .:....:::|.:.....|     ..|..|.|.|.:.:.  |.|:.:||...|:...:.|....:.
  Fly  1412 QQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNN 1476

  Fly   489 RGTEDAESEPLTSEVAVEEIGETITIISTSSED----TAGS----PPTKMEEDGATDSLPKKEDA 545
                                |..:.....:..|    ||.|    .|:..::......|.::...
  Fly  1477 --------------------GFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQ 1521

  Fly   546 AEDKSEQESSSQGQNKAGGSTDEPELIDHQATREAQSKSGKD------------TAGKPVTMQEK 598
            .:.:...:...|.|.:......:.:|...|..::.|.:..:.            .|...:.:..|
  Fly  1522 QQQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPK 1586

  Fly   599 TTTQSAPVPVDLHDTDEESSSLTDSSKHDD---HPRSAKAKPPALKLALDDSKSELELSGTPQPP 660
            ......|.|.|.....:....|.......|   ||.:|.|...|
  Fly  1587 PIESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAAAAAVA--------------------- 1630

  Fly   661 SAPARTPLLRKLPHRDRSESPMVDDDATTASDHSTARSTRRRCSSTPVIDSIPNSPASSEHTDDR 725
            ||.|:.....|...::...:......|:..|..|...|:.....:.|.:||.......::..|..
  Fly  1631 SAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRL 1695

  Fly   726 RETRAASKK 734
            :...||.|:
  Fly  1696 KLLEAAEKE 1704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408	14/82 (17%)
		PHA03249	402..>582	CDD:223023	27/212 (13%)
		Bromo_brd8_like	729..833	CDD:99939	3/6 (50%)
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408
		Bromo_Brdt_II_like	481..581	CDD:99930
		BET	951..1015	CDD:293640	3/5 (60%)
		BRD4_CDT	<2026..2046	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810